Protein profile

PA1451

hypothetical protein

Genome: NC_002516.2

Gene: PA1451 Structure source: AlphaFold UniProt Q9I3Q0
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Amino acids 447
Annotations 0
Features 35
PDB binders 0
Druggability 0.971

Overview

Basic information about this protein and its source genome.

Accession
PA1451
Assembly
Pseudomonas aeruginosa PAO1, complete genome
Gene
PA1451
Status
annotated
Amino acids
447
Structure source
AlphaFold

Target profile

Computed evidence for target prioritization.

Human off-target
No hit
Gut microbiome off-target
hit
Essential (DEG)
N
Localization
CytoplasmicMembrane

Selected Druggability evidence

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.971
Structure –
Pocket –

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

No GO or EC annotations are currently loaded for this protein.

Sequence Features

Domain/signature hits from InterPro and related databases.

35 records
Show feature table
Start End DB Term Name
1 12 Phobius SIGNAL_PEPTIDE_N_REGION N-terminal region of a signal peptide.
261 265 Phobius NON_CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.
26 447 PANTHER PTHR30373 UNCHARACTERIZED
265 287 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
412 447 MobiDBLite mobidb-lite consensus disorder prediction
24 28 Phobius SIGNAL_PEPTIDE_C_REGION C-terminal region of a signal peptide.
338 348 Phobius CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the cytoplasm.
244 261 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
13 23 Phobius SIGNAL_PEPTIDE_H_REGION Hydrophobic region of a signal peptide.
349 371 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
65 210 Gene3D G3DSA:3.10.310.50 -
217 239 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
243 260 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
288 293 Phobius CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the cytoplasm.
1 29 SignalP_GRAM_NEGATIVE SignalP-noTM SignalP-noTM
321 340 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
1 38 SignalP_GRAM_POSITIVE SignalP-TM SignalP-TM
408 447 MobiDBLite mobidb-lite consensus disorder prediction
218 238 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
313 317 Phobius NON_CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.
381 403 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
349 371 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
239 242 Phobius CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the cytoplasm.
377 399 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
13 35 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
1 28 Phobius SIGNAL_PEPTIDE Signal peptide region
29 217 Phobius NON_CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.
372 376 Phobius NON_CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.
294 312 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
400 447 Phobius CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the cytoplasm.
318 337 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
294 311 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
76 199 Pfam PF04536 TPM domain
76 199 InterPro IPR007621 TPM domain
266 287 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

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Structural evidence

0 + 1

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry Method Resolution Chain Coverage Links Status
AlphaFold PA1451
AlphaFold — — full sequence — Viewing
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Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET Sticks Spheres Surfaces Druggability Labels Zoom Positions
1 0.971
3 0.618
12 0.449