Protein profile

PA1452

flagellar biosynthesis protein FlhA

Genome: NC_002516.2

Gene: flhA PA1452 Structure source: AlphaFold UniProt Q9I3P9
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Amino acids 707
Annotations 4
Features 53
PDB binders 0
Druggability 0.87

Overview

Basic information about this protein and its source genome.

Accession
PA1452
Assembly
Pseudomonas aeruginosa PAO1, complete genome
Gene
flhA PA1452
Status
annotated
Amino acids
707
Structure source
AlphaFold
GO
GO:0005886 The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. GO:0044780 The assembly of a bacterial-type flagellum, a motor complex composed of an extracellular helical protein filament coupled to a rotary motor embedded in the cell envelope which functions in cell motility. GO:0009306 The controlled release of proteins from a cell. GO:0016020 A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it.

Target profile

Computed evidence for target prioritization.

Human off-target
No hit
Gut microbiome off-target
hit
Essential (DEG)
N
Localization
CytoplasmicMembrane

Selected Druggability evidence

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.87
Structure –
Pocket –

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

4 GO

Gene Ontology (GO)

4
  • GO:0005886 The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
  • GO:0044780 The assembly of a bacterial-type flagellum, a motor complex composed of an extracellular helical protein filament coupled to a rotary motor embedded in the cell envelope which functions in cell motility.
  • GO:0009306 The controlled release of proteins from a cell.
  • GO:0016020 A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it.

Sequence Features

Domain/signature hits from InterPro and related databases.

53 records
Show feature table
Start End DB Term Name
287 305 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
76 98 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
513 600 Gene3D G3DSA:1.10.8.540 FHIPEP family, domain 3
513 600 InterPro IPR042193 FHIPEP, domain 3
47 69 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
7 707 PIRSF PIRSF005419 FlhA
7 707 InterPro IPR001712 Type III secretion system FHIPEP
209 231 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
286 305 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
267 286 Phobius CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the cytoplasm.
117 140 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
73 97 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
46 66 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
98 116 Phobius NON_CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.
241 266 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
209 229 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
306 310 Phobius NON_CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.
38 51 PRINTS PR00949 Type III secretion system inner membrane A protein family signature
38 51 InterPro IPR001712 Type III secretion system FHIPEP
75 94 PRINTS PR00949 Type III secretion system inner membrane A protein family signature
75 94 InterPro IPR001712 Type III secretion system FHIPEP
161 179 PRINTS PR00949 Type III secretion system inner membrane A protein family signature
161 179 InterPro IPR001712 Type III secretion system FHIPEP
191 208 PRINTS PR00949 Type III secretion system inner membrane A protein family signature
191 208 InterPro IPR001712 Type III secretion system FHIPEP
142 158 PRINTS PR00949 Type III secretion system inner membrane A protein family signature
142 158 InterPro IPR001712 Type III secretion system FHIPEP
242 256 PRINTS PR00949 Type III secretion system inner membrane A protein family signature
242 256 InterPro IPR001712 Type III secretion system FHIPEP
147 170 ProSitePatterns PS00994 Bacterial export FHIPEP family signature.
147 170 InterPro IPR025505 FHIPEP conserved site
369 512 Gene3D G3DSA:3.40.30.60 FHIPEP family, domain 1
369 512 InterPro IPR042194 FHIPEP, domain 1
230 240 Phobius NON_CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.
141 208 Phobius CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the cytoplasm.
329 707 Phobius CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the cytoplasm.
16 705 PANTHER PTHR30161 FLAGELLAR EXPORT PROTEIN, MEMBRANE FLHA SUBUNIT-RELATED
16 705 InterPro IPR001712 Type III secretion system FHIPEP
41 45 Phobius NON_CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.
67 72 Phobius CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the cytoplasm.
1 20 Phobius CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the cytoplasm.
118 140 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
22 704 NCBIfam TIGR01398 flagellar biosynthesis protein FlhA
22 704 InterPro IPR006301 Flagellar biosynthesis protein FlhA
21 43 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
21 40 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
604 704 Gene3D G3DSA:3.40.50.12790 FHIPEP family, domain 4
604 704 InterPro IPR042196 FHIPEP, domain 4
309 328 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
311 328 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
251 273 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
31 696 Pfam PF00771 FHIPEP family
31 696 InterPro IPR001712 Type III secretion system FHIPEP

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

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Structural evidence

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Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry Method Resolution Chain Coverage Links Status
AlphaFold PA1452
AlphaFold — — full sequence — Viewing
Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET Sticks Spheres Surfaces Druggability Labels Zoom Positions
16 0.779
2 0.555
6 0.511