Protein profile

PA1454

flagellar synthesis regulator FleN

Genome: NC_002516.2

Gene: fleN PA1454 Structure source: Experimental + AlphaFold UniProt G3XD64
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Amino acids 280
Annotations 4
Features 12
PDB binders 7
Druggability 0.9

Overview

Basic information about this protein and its source genome.

Accession
PA1454
Assembly
Pseudomonas aeruginosa PAO1, complete genome
Gene
fleN PA1454
Status
annotated
Amino acids
280
Structure source
Experimental + AlphaFold
GO
GO:0009898 The leaflet of the plasma membrane that faces the cytoplasm, including any protein embedded in, attached to, or peripherally associated with it. GO:0005829 The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. GO:0005524 Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. GO:0016887 Catalysis of the reaction: ATP + H2O = ADP + H+ phosphate. ATP hydrolysis is used in some reactions as an energy source, for example to catalyze a reaction or drive transport against a concentration gradient.

Target profile

Computed evidence for target prioritization.

Human off-target
hit
Human identity (%)
31.013
Human E-value
1.81e-08
Gut microbiome off-target
hit
Essential (DEG)
N
Localization
CytoplasmicMembrane

Selected Druggability evidence

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.9
Structure –
Pocket –

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

4 GO

Gene Ontology (GO)

4
  • GO:0009898 The leaflet of the plasma membrane that faces the cytoplasm, including any protein embedded in, attached to, or peripherally associated with it.
  • GO:0005829 The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
  • GO:0005524 Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
  • GO:0016887 Catalysis of the reaction: ATP + H2O = ADP + H+ phosphate. ATP hydrolysis is used in some reactions as an energy source, for example to catalyze a reaction or drive transport against a concentration gradient.

Sequence Features

Domain/signature hits from InterPro and related databases.

12 records
Show feature table
Start End DB Term Name
9 260 PANTHER PTHR43384 SEPTUM SITE-DETERMINING PROTEIN MIND HOMOLOG, CHLOROPLASTIC-RELATED
10 251 FunFam G3DSA:3.40.50.300:FF:000158 Site-determining protein
2 273 PIRSF PIRSF003092 MinD
2 273 InterPro IPR025501 ATP binding protein MinD/FleN
11 251 Gene3D G3DSA:3.40.50.300 -
11 251 InterPro IPR027417 P-loop containing nucleoside triphosphate hydrolase
24 240 CDD cd02038 FlhG-like
24 240 InterPro IPR033875 Flagellum site-determining protein FlhG
11 250 Pfam PF10609 NUBPL iron-transfer P-loop NTPase
11 250 InterPro IPR033756 Flagellum site-determining protein YlxH/ Fe-S cluster assembling factor NBP35
11 269 SUPERFAMILY SSF52540 P-loop containing nucleoside triphosphate hydrolases
11 269 InterPro IPR027417 P-loop containing nucleoside triphosphate hydrolase

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

3D visualization script Full viewer

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Structural evidence

3 + 1

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry Method Resolution Chain Coverage Links Status
PDB 5J1J
X-ray 1.55 Å A,B
100.0% 1-280
PDBe RCSB PDBj File
Viewing
PDB 5JVF
X-ray 1.66 Å A
100.0% 1-280
PDBe RCSB PDBj File
Loaded
PDB 7EJW
X-ray 1.98 Å A,B
100.0% 1-280
PDBe RCSB PDBj File
Loaded
AlphaFold PA1454
AlphaFold — — full sequence — Loaded
Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET Sticks Spheres Surfaces Druggability Labels Zoom Positions
4 0.347
5 0.345
1 0.207

Pockets (P2RANK)

Showing top-ranked P2Rank candidates by probability. Probability is color-coded per P2Rank calibration: high (≥ 0.5), medium (0.2 – 0.49), low (< 0.2).

P2RANK Sticks Spheres Surfaces Score Probability Labels Zoom Positions
1 18.41 0.822
2 14.05 0.709
3 1.86 0.036

Ligand evidence

Ligands grouped by evidence source. PDB ligands keep the source crystal visible, and loaded crystals can be opened directly in the structure viewer.

57 records

Highest-confidence structural evidence: ligands co-crystallized with this exact protein. If the source PDB is loaded in TPW, use Open crystal to inspect it in the structure viewer.

Show only:
Ligand Source crystal MW · LogP · TPSA Lipinski PAINS SMILES
ANP
5J1J 1.55 Å Open crystal
506.2 Da LogP -2.06 TPSA 281.9 3 viol. ✓ Clean c1nc(c2c(n1)n(cn2)[C@H]3[C@@H]([C@@H]([C@H](O3)…

PDB and ChEMBL records on this protein are shown in full. ChEMBL records from similar proteins are capped at the top 100 per protein (by pchembl) and ZINC at the top 50 (Tanimoto ≥ 0.5). ADME columns are descriptor-based screening flags, not experimental toxicity results.