Protein profile

PA1461

flagellar motor protein MotD

Genome: NC_002516.2

Gene: GNQ48_02285 CAZ10_08275 motD motB_2 PA1461 DT376_21180 L4V69_23500 orf2 IPC1295_04000 GUL26_07365 PAERUG_P19_London_7_VIM_2_05_10_04767 Structure source: AlphaFold UniProt G3XD90 UniProt O87127
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Amino acids 296
Annotations 3
Features 20
PDB binders 5
Druggability 0.527

Overview

Basic information about this protein and its source genome.

Accession
PA1461
Assembly
Pseudomonas aeruginosa PAO1, complete genome
Gene
GNQ48_02285 CAZ10_08275 motD motB_2 PA1461 DT376_21180 L4V69_23500 orf2 IPC1295_04000 GUL26_07365 PAERUG_P19_London_7_VIM_2_05_10_04767
Status
annotated
Amino acids
296
Structure source
AlphaFold
GO
GO:0120101 A hetero-hexameric complex of 2 membrane proteins, A and B, with stoichiometry A4B2. The A and B proteins form a channel through which flow the ions that power the bacterial-type flagellum. They form the stator, or nonrotating portion, of the flagellum motor with the B protein apparently attached to the peptidoglycan cell wall. Examples include the H+ driven MotA-MotB stator complex of Escherichia coli and Salmonella enterica, and the Na+ driven PomA-PomB stator complex of Vibrio and Shewanella species. GO:0071973 Cell motility due to the motion of one or more bacterial-type flagella. A bacterial-type flagellum is a motor complex composed of an extracellular helical protein filament coupled to a rotary motor embedded in the cell envelope. GO:0071978 Bacterial-type flagellum-dependent cell motility in which the action of numerous flagella results in the smooth movement of a group of cells along a solid surface. Swarming motility is observed in groups of bacteria.

Target profile

Computed evidence for target prioritization.

Human off-target
No hit
Gut microbiome off-target
hit
Essential (DEG)
N
Localization
CytoplasmicMembrane

Selected Druggability evidence

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.527
Structure –
Pocket –

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

3 GO

Gene Ontology (GO)

3
  • GO:0120101 A hetero-hexameric complex of 2 membrane proteins, A and B, with stoichiometry A4B2. The A and B proteins form a channel through which flow the ions that power the bacterial-type flagellum. They form the stator, or nonrotating portion, of the flagellum motor with the B protein apparently attached to the peptidoglycan cell wall. Examples include the H+ driven MotA-MotB stator complex of Escherichia coli and Salmonella enterica, and the Na+ driven PomA-PomB stator complex of Vibrio and Shewanella species.
  • GO:0071973 Cell motility due to the motion of one or more bacterial-type flagella. A bacterial-type flagellum is a motor complex composed of an extracellular helical protein filament coupled to a rotary motor embedded in the cell envelope.
  • GO:0071978 Bacterial-type flagellum-dependent cell motility in which the action of numerous flagella results in the smooth movement of a group of cells along a solid surface. Swarming motility is observed in groups of bacteria.

Sequence Features

Domain/signature hits from InterPro and related databases.

20 records
Show feature table
Start End DB Term Name
134 240 CDD cd07185 OmpA_C-like
134 240 InterPro IPR006665 OmpA-like domain
39 296 Phobius NON_CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.
127 240 SUPERFAMILY SSF103088 OmpA-like
127 240 InterPro IPR036737 OmpA-like domain superfamily
4 57 Pfam PF13677 Membrane MotB of proton-channel complex MotA/MotB
4 57 InterPro IPR025713 Motility protein B-like, N-terminal domain
124 244 ProSiteProfiles PS51123 OmpA-like domain profile.
124 244 InterPro IPR006665 OmpA-like domain
1 20 Phobius CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the cytoplasm.
145 234 Pfam PF00691 OmpA family
145 234 InterPro IPR006665 OmpA-like domain
17 39 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
66 85 MobiDBLite mobidb-lite consensus disorder prediction
2 242 PANTHER PTHR30329 STATOR ELEMENT OF FLAGELLAR MOTOR COMPLEX
21 38 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
251 296 MobiDBLite mobidb-lite consensus disorder prediction
77 255 Gene3D G3DSA:3.30.1330.60 -
77 255 InterPro IPR036737 OmpA-like domain superfamily
64 97 MobiDBLite mobidb-lite consensus disorder prediction

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

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Structural evidence

0 + 1

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry Method Resolution Chain Coverage Links Status
AlphaFold PA1461
AlphaFold — — full sequence — Viewing
Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET Sticks Spheres Surfaces Druggability Labels Zoom Positions
4 0.527
3 0.459
1 0.223

Ligand evidence

Ligands grouped by evidence source. PDB ligands keep the source crystal visible, and loaded crystals can be opened directly in the structure viewer.

55 records

Structural evidence inferred from similar proteins. The source crystal indicates where the ligand was observed; the UniProt column identifies the homologous protein carrying that ligand.

Show only:
Ligand Source crystal UniProt (homolog) MW · LogP · TPSA Lipinski PAINS SMILES
5GP
5Y61
Q9I4L6 363.2 Da LogP -2.57 TPSA 206.0 1 viol. ✓ Clean c1nc2c(n1[C@H]3[C@@H]([C@@H]([C@H](O3)COP(=O)(O…
7QA
5U1H
P13794 305.3 Da LogP -1.21 TPSA 179.0 1 viol. ✓ Clean C[C@H](C(=O)O)NC(=O)[C@H](CCC[C@H](C(=O)O)N)NC(…
API
3TD4
Q6RYW5 190.2 Da LogP -1.02 TPSA 126.6 ✓ Ro5 ✓ Clean C(C[C@H](C(=O)O)N)C[C@@H](C(=O)O)N
C8E
4RLC
P13794 306.4 Da LogP 2.41 TPSA 57.2 ✓ Ro5 ✓ Clean CCCCCCCCOCCOCCOCCOCCO
SRT
4G88
Q6RYW5 150.1 Da LogP -2.12 TPSA 115.1 ✓ Ro5 ✓ Clean [C@H]([C@H](C(=O)O)O)(C(=O)O)O

PDB and ChEMBL records on this protein are shown in full. ChEMBL records from similar proteins are capped at the top 100 per protein (by pchembl) and ZINC at the top 50 (Tanimoto ≥ 0.5). ADME columns are descriptor-based screening flags, not experimental toxicity results.