Amino acids
296
Annotations
2
Features
11
PDB binders
0
Druggability
0.826
Overview
Basic information about this protein and its source genome.
- Accession
- PA1463
- Gene
- orf4 IPC1295_04010 GUL26_07375 PA1463 PAERUG_P19_London_7_VIM_2_05_10_04769 CAZ10_08285
- Status
- annotated
- Amino acids
- 296
- Structure source
- AlphaFold
GO
GO:0006935 The directed movement of a motile cell or organism, or the directed growth of a cell guided by a specific chemical concentration gradient. Movement may be towards a higher concentration (positive chemotaxis) or towards a lower concentration (negative chemotaxis).
GO:0007165 The cellular process in which a signal is conveyed to trigger a change in the activity or state of a cell. Signal transduction begins with reception of a signal (e.g. a ligand binding to a receptor or receptor activation by a stimulus such as light), or for signal transduction in the absence of ligand, signal-withdrawal or the activity of a constitutively active receptor. Signal transduction ends with regulation of a downstream cellular process, e.g. regulation of transcription or regulation of a metabolic process. Signal transduction covers signaling from receptors located on the surface of the cell and signaling via molecules located within the cell. For signaling between cells, signal transduction is restricted to events at and within the receiving cell.
Target profile
Computed evidence for target prioritization.
- Human off-target
- No hit
- Gut microbiome off-target
- hit
- Essential (DEG)
- N
- Localization
- Cytoplasmic
Selected Druggability evidence
Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.
FPocket
0.826
Sequence
Primary amino-acid sequence viewer.
Functional Annotations
Enzyme classification and Gene Ontology terms linked to this protein.
2 GO
Gene Ontology (GO)
2- GO:0006935 The directed movement of a motile cell or organism, or the directed growth of a cell guided by a specific chemical concentration gradient. Movement may be towards a higher concentration (positive chemotaxis) or towards a lower concentration (negative chemotaxis).
- GO:0007165 The cellular process in which a signal is conveyed to trigger a change in the activity or state of a cell. Signal transduction begins with reception of a signal (e.g. a ligand binding to a receptor or receptor activation by a stimulus such as light), or for signal transduction in the absence of ligand, signal-withdrawal or the activity of a constitutively active receptor. Signal transduction ends with regulation of a downstream cellular process, e.g. regulation of transcription or regulation of a metabolic process. Signal transduction covers signaling from receptors located on the surface of the cell and signaling via molecules located within the cell. For signaling between cells, signal transduction is restricted to events at and within the receiving cell.
Sequence Features
Domain/signature hits from InterPro and related databases.
11 records
Show feature table
| Start | End | DB | Term | Name |
|---|---|---|---|---|
| 1 | 296 | PIRSF | PIRSF020479 | UCP020479_CheW |
| 1 | 296 | InterPro | IPR014506 | Uncharacterised conserved protein UCP020479, signal transduction CheW-like |
| 148 | 286 | ProSiteProfiles | PS50851 | CheW-like domain profile. |
| 148 | 286 | InterPro | IPR002545 | CheW-like domain |
| 148 | 282 | SUPERFAMILY | SSF50341 | CheW-like |
| 148 | 282 | InterPro | IPR036061 | CheW-like domain superfamily |
| 150 | 282 | Pfam | PF01584 | CheW-like domain |
| 150 | 282 | InterPro | IPR002545 | CheW-like domain |
| 152 | 280 | CDD | cd00588 | CheW_like |
| 146 | 281 | SMART | SM00260 | chew_2 |
| 146 | 281 | InterPro | IPR002545 | CheW-like domain |
3D Structure
Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.
Loading 3D structure...
Legend
High
Medium
Low
Structural evidence
0 + 1Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.
| Entry | Method | Resolution | Chain | Coverage | Links | Status |
|---|---|---|---|---|---|---|
|
AlphaFold
PA1463
|
AlphaFold | — | — | full sequence | — | Viewing |
Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer
Pockets (FPOCKET)
Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).
| FPOCKET | Sticks | Spheres | Surfaces | Druggability | Labels | Zoom | Positions |
|---|---|---|---|---|---|---|---|
| 1 | 0.826 |