Protein profile

PA1464

purine-binding chemotaxis protein

Genome: NC_002516.2

Gene: IPC1295_04015 cheW_3 GNQ48_02270 PA1464 ALP65_02789 PAERUG_P19_London_7_VIM_2_05_10_04770 cheW CAZ10_08290 L4V69_23485 DT376_18705 GUL26_07380 Structure source: AlphaFold UniProt O87130 UniProt G3XD72
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Amino acids 159
Annotations 3
Features 14
PDB binders 0
Druggability 0.27

Overview

Basic information about this protein and its source genome.

Accession
PA1464
Assembly
Pseudomonas aeruginosa PAO1, complete genome
Gene
IPC1295_04015 cheW_3 GNQ48_02270 PA1464 ALP65_02789 PAERUG_P19_London_7_VIM_2_05_10_04770 cheW CAZ10_08290 L4V69_23485 DT376_18705 GUL26_07380
Status
annotated
Amino acids
159
Structure source
AlphaFold
GO
GO:0005829 The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. GO:0006935 The directed movement of a motile cell or organism, or the directed growth of a cell guided by a specific chemical concentration gradient. Movement may be towards a higher concentration (positive chemotaxis) or towards a lower concentration (negative chemotaxis). GO:0007165 The cellular process in which a signal is conveyed to trigger a change in the activity or state of a cell. Signal transduction begins with reception of a signal (e.g. a ligand binding to a receptor or receptor activation by a stimulus such as light), or for signal transduction in the absence of ligand, signal-withdrawal or the activity of a constitutively active receptor. Signal transduction ends with regulation of a downstream cellular process, e.g. regulation of transcription or regulation of a metabolic process. Signal transduction covers signaling from receptors located on the surface of the cell and signaling via molecules located within the cell. For signaling between cells, signal transduction is restricted to events at and within the receiving cell.

Target profile

Computed evidence for target prioritization.

Human off-target
No hit
Gut microbiome off-target
hit
Essential (DEG)
N
Localization
Cytoplasmic

Selected Druggability evidence

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.27
Structure –
Pocket –

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

3 GO

Gene Ontology (GO)

3
  • GO:0005829 The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
  • GO:0006935 The directed movement of a motile cell or organism, or the directed growth of a cell guided by a specific chemical concentration gradient. Movement may be towards a higher concentration (positive chemotaxis) or towards a lower concentration (negative chemotaxis).
  • GO:0007165 The cellular process in which a signal is conveyed to trigger a change in the activity or state of a cell. Signal transduction begins with reception of a signal (e.g. a ligand binding to a receptor or receptor activation by a stimulus such as light), or for signal transduction in the absence of ligand, signal-withdrawal or the activity of a constitutively active receptor. Signal transduction ends with regulation of a downstream cellular process, e.g. regulation of transcription or regulation of a metabolic process. Signal transduction covers signaling from receptors located on the surface of the cell and signaling via molecules located within the cell. For signaling between cells, signal transduction is restricted to events at and within the receiving cell.

Sequence Features

Domain/signature hits from InterPro and related databases.

14 records
Show feature table
Start End DB Term Name
34 143 Gene3D G3DSA:2.40.50.180 -
17 142 Gene3D G3DSA:2.30.30.40 SH3 Domains
13 153 ProSiteProfiles PS50851 CheW-like domain profile.
13 153 InterPro IPR002545 CheW-like domain
11 154 SUPERFAMILY SSF50341 CheW-like
11 154 InterPro IPR036061 CheW-like domain superfamily
13 152 CDD cd00732 CheW
15 151 Pfam PF01584 CheW-like domain
15 151 InterPro IPR002545 CheW-like domain
6 156 PANTHER PTHR22617 CHEMOTAXIS SENSOR HISTIDINE KINASE-RELATED
6 156 InterPro IPR039315 Chemotaxis protein CheW
11 148 SMART SM00260 chew_2
11 148 InterPro IPR002545 CheW-like domain
34 101 FunFam G3DSA:2.40.50.180:FF:000001 Chemotaxis protein CheW

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

3D visualization script Full viewer

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Structural evidence

0 + 1

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry Method Resolution Chain Coverage Links Status
AlphaFold PA1464
AlphaFold — — full sequence — Viewing
Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET Sticks Spheres Surfaces Druggability Labels Zoom Positions
2 0.27