Target Pathogen

Overview

Basic information about this protein and its source genome.

Accession: PA1467
Assembly: Pseudomonas aeruginosa PAO1, complete genome
Gene: PA1467
Status: annotated
Amino acids: 323
Structure source: AlphaFold

GO

GO:0003700 A transcription regulator activity that modulates transcription of gene sets via selective and non-covalent binding to a specific double-stranded genomic DNA sequence (sometimes referred to as a motif) within a cis-regulatory region. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units, and include bacterial operons. GO:0006355 Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription.

Target profile

Computed evidence for target prioritization.

Human off-target: No hit
Gut microbiome off-target: hit
Essential (DEG): N
Localization: Cytoplasmic

Selected Druggability evidence

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.927

Structure –

Pocket –

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

2 GO

Gene Ontology (GO)

2

GO:0003700 A transcription regulator activity that modulates transcription of gene sets via selective and non-covalent binding to a specific double-stranded genomic DNA sequence (sometimes referred to as a motif) within a cis-regulatory region. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units, and include bacterial operons.
GO:0006355 Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription.

Sequence Features

Domain/signature hits from InterPro and related databases.

20 records

Show feature table

Start	End	DB	Term	Name
4	63	ProSiteProfiles	PS51000	DeoR-type HTH domain profile.
4	63	InterPro	IPR001034	DeoR-type HTH domain
1	7	Phobius	SIGNAL_PEPTIDE_N_REGION	N-terminal region of a signal peptide.
7	64	SUPERFAMILY	SSF46785	Winged helix DNA-binding domain
7	64	InterPro	IPR036390	Winged helix DNA-binding domain superfamily
7	62	Pfam	PF08279	HTH domain
7	62	InterPro	IPR013196	Helix-turn-helix, type 11
20	323	Phobius	NON_CYTOPLASMIC_DOMAIN	Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.
16	19	Phobius	SIGNAL_PEPTIDE_C_REGION	C-terminal region of a signal peptide.
8	15	Phobius	SIGNAL_PEPTIDE_H_REGION	Hydrophobic region of a signal peptide.
64	320	PIRSF	PIRSF016838	PafC
64	320	InterPro	IPR028349	Protein PafC
1	55	PIRSF	PIRSF016838	PafC
1	55	InterPro	IPR028349	Protein PafC
1	19	Phobius	SIGNAL_PEPTIDE	Signal peptide region
4	65	Gene3D	G3DSA:1.10.10.10	-
4	65	InterPro	IPR036388	Winged helix-like DNA-binding domain superfamily
142	310	Pfam	PF13280	WYL domain
142	310	InterPro	IPR026881	WYL domain
3	312	PANTHER	PTHR34580	-

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

Loading 3D structure...

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Structural evidence

0 + 1

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry	Method	Resolution	Chain	Coverage	Links	Status
AlphaFold PA1467	AlphaFold	—	—	full sequence	—	Viewing

Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET	Sticks	Spheres	Surfaces	Druggability	Labels	Zoom	Positions
3				0.927
4				0.499
10				0.224

PA1467