Protein profile

PA1477

heme exporter protein CcmC

Genome: NC_002516.2

Gene: ccmC PA1477 Structure source: AlphaFold UniProt Q9I3N5

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Amino acids 252

Annotations 12

Features 37

PDB binders 0

Druggability 0.908

Overview

Basic information about this protein and its source genome.

Accession: PA1477
Assembly: Pseudomonas aeruginosa PAO1, complete genome
Gene: ccmC PA1477
Status: annotated
Amino acids: 252
Structure source: AlphaFold

GO:0005886 The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. GO:0004096 Catalysis of the reaction: 2 H2O2 = O2 + 2 H2O. GO:0020037 Binding to a heme, a compound composed of iron complexed in a porphyrin (tetrapyrrole) ring. GO:0015232 Enables the transfer of heme from one side of a membrane to the other. GO:0071978 Bacterial-type flagellum-dependent cell motility in which the action of numerous flagella results in the smooth movement of a group of cells along a solid surface. Swarming motility is observed in groups of bacteria. GO:0071977 Bacterial-type flagellum-dependent cell motility that results in the smooth movement of a cell through a liquid medium.

Target profile

Computed evidence for target prioritization.

Human off-target: No hit
Gut microbiome off-target: hit
Essential (DEG): Y
Localization: CytoplasmicMembrane

Selected Druggability evidence

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.908

Structure –

Pocket –

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

12 GO

Gene Ontology (GO)

GO:0005886 The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
GO:0004096 Catalysis of the reaction: 2 H2O2 = O2 + 2 H2O.
GO:0020037 Binding to a heme, a compound composed of iron complexed in a porphyrin (tetrapyrrole) ring.
GO:0015232 Enables the transfer of heme from one side of a membrane to the other.
GO:0071978 Bacterial-type flagellum-dependent cell motility in which the action of numerous flagella results in the smooth movement of a group of cells along a solid surface. Swarming motility is observed in groups of bacteria.
GO:0071977 Bacterial-type flagellum-dependent cell motility that results in the smooth movement of a cell through a liquid medium.
GO:0017004 The aggregation, arrangement and bonding together of a cytochrome complex. A cytochrome complex is a protein complex in which at least one of the proteins is a cytochrome, i.e. a heme-containing protein involved in catalysis of redox reactions.
GO:0009247 The chemical reactions and pathways resulting in the formation of glycolipid, a class of 1,2-di-O-acylglycerols joined at oxygen 3 by a glycosidic linkage to a carbohydrate part (usually a mono-, di- or tri-saccharide).
GO:0002049 The chemical reactions and pathways resulting in the formation of the siderochrome pyoverdine.
GO:0043107 Any process involved in the controlled movement of a bacterial cell which is dependent on the presence of type IV pili. Includes social gliding motility and twitching motility.
GO:0016020 A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it.
GO:0015886 The directed movement of heme, any compound of iron complexed in a porphyrin (tetrapyrrole) ring, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.

Sequence Features

Domain/signature hits from InterPro and related databases.

37 records

Show feature table

Start	End	DB	Term	Name
160	179	Phobius	TRANSMEMBRANE	Region of a membrane-bound protein predicted to be embedded in the membrane.
118	128	Phobius	NON_CYTOPLASMIC_DOMAIN	Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.
58	86	Phobius	TRANSMEMBRANE	Region of a membrane-bound protein predicted to be embedded in the membrane.
160	182	TMHMM	TMhelix	Region of a membrane-bound protein predicted to be embedded in the membrane.
15	186	Pfam	PF01578	Cytochrome C assembly protein
15	186	InterPro	IPR002541	Cytochrome c assembly protein
203	224	Phobius	TRANSMEMBRANE	Region of a membrane-bound protein predicted to be embedded in the membrane.
149	159	Phobius	CYTOPLASMIC_DOMAIN	Region of a membrane-bound protein predicted to be outside the membrane, in the cytoplasm.
23	45	TMHMM	TMhelix	Region of a membrane-bound protein predicted to be embedded in the membrane.
64	84	PRINTS	PR01386	Cytochrome c-type biogenesis protein CcmC signature
64	84	InterPro	IPR003557	Cytochrome c-type biogenesis protein CcmC
102	122	PRINTS	PR01386	Cytochrome c-type biogenesis protein CcmC signature
102	122	InterPro	IPR003557	Cytochrome c-type biogenesis protein CcmC
47	64	PRINTS	PR01386	Cytochrome c-type biogenesis protein CcmC signature
47	64	InterPro	IPR003557	Cytochrome c-type biogenesis protein CcmC
158	184	PRINTS	PR01386	Cytochrome c-type biogenesis protein CcmC signature
158	184	InterPro	IPR003557	Cytochrome c-type biogenesis protein CcmC
206	230	PRINTS	PR01386	Cytochrome c-type biogenesis protein CcmC signature
206	230	InterPro	IPR003557	Cytochrome c-type biogenesis protein CcmC
123	143	PRINTS	PR01386	Cytochrome c-type biogenesis protein CcmC signature
123	143	InterPro	IPR003557	Cytochrome c-type biogenesis protein CcmC
129	148	Phobius	TRANSMEMBRANE	Region of a membrane-bound protein predicted to be embedded in the membrane.
47	57	Phobius	NON_CYTOPLASMIC_DOMAIN	Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.
47	230	NCBIfam	TIGR01191	heme ABC transporter permease CcmC
47	230	InterPro	IPR003557	Cytochrome c-type biogenesis protein CcmC
87	92	Phobius	CYTOPLASMIC_DOMAIN	Region of a membrane-bound protein predicted to be outside the membrane, in the cytoplasm.
94	116	TMHMM	TMhelix	Region of a membrane-bound protein predicted to be embedded in the membrane.
180	202	Phobius	NON_CYTOPLASMIC_DOMAIN	Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.
202	224	TMHMM	TMhelix	Region of a membrane-bound protein predicted to be embedded in the membrane.
93	117	Phobius	TRANSMEMBRANE	Region of a membrane-bound protein predicted to be embedded in the membrane.
23	46	Phobius	TRANSMEMBRANE	Region of a membrane-bound protein predicted to be embedded in the membrane.
131	153	TMHMM	TMhelix	Region of a membrane-bound protein predicted to be embedded in the membrane.
1	22	Phobius	CYTOPLASMIC_DOMAIN	Region of a membrane-bound protein predicted to be outside the membrane, in the cytoplasm.
225	252	Phobius	CYTOPLASMIC_DOMAIN	Region of a membrane-bound protein predicted to be outside the membrane, in the cytoplasm.
60	82	TMHMM	TMhelix	Region of a membrane-bound protein predicted to be embedded in the membrane.
32	214	PANTHER	PTHR30071	HEME EXPORTER PROTEIN C
32	214	InterPro	IPR045062	Cytochrome c-type biogenesis protein CcsA/CcmC

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

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Structural evidence

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Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry	Method	Resolution	Chain	Coverage	Links	Status
AlphaFold PA1477	AlphaFold	—	—	full sequence	—	Viewing

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Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET	Sticks	Spheres	Surfaces	Druggability	Labels	Zoom	Positions
1				0.908
5				0.319