Protein profile

PA1480

cytochrome c-type biogenesis protein CcmF

Genome: NC_002516.2

Gene: ccmF PA1480 Structure source: AlphaFold UniProt Q9I3N2
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Amino acids 657
Annotations 12
Features 85
PDB binders 0
Druggability 0.879

Overview

Basic information about this protein and its source genome.

Accession
PA1480
Assembly
Pseudomonas aeruginosa PAO1, complete genome
Gene
ccmF PA1480
Status
annotated
Amino acids
657
Structure source
AlphaFold
GO
GO:0005886 The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. GO:0004096 Catalysis of the reaction: 2 H2O2 = O2 + 2 H2O. GO:0020037 Binding to a heme, a compound composed of iron complexed in a porphyrin (tetrapyrrole) ring. GO:0015232 Enables the transfer of heme from one side of a membrane to the other. GO:0016491 Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. GO:0071978 Bacterial-type flagellum-dependent cell motility in which the action of numerous flagella results in the smooth movement of a group of cells along a solid surface. Swarming motility is observed in groups of bacteria.

Target profile

Computed evidence for target prioritization.

Human off-target
No hit
Gut microbiome off-target
hit
Essential (DEG)
Y
Localization
CytoplasmicMembrane

Selected Druggability evidence

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.879
Structure –
Pocket –

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

12 GO

Gene Ontology (GO)

12
  • GO:0005886 The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
  • GO:0004096 Catalysis of the reaction: 2 H2O2 = O2 + 2 H2O.
  • GO:0020037 Binding to a heme, a compound composed of iron complexed in a porphyrin (tetrapyrrole) ring.
  • GO:0015232 Enables the transfer of heme from one side of a membrane to the other.
  • GO:0016491 Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced.
  • GO:0071978 Bacterial-type flagellum-dependent cell motility in which the action of numerous flagella results in the smooth movement of a group of cells along a solid surface. Swarming motility is observed in groups of bacteria.
  • GO:0071977 Bacterial-type flagellum-dependent cell motility that results in the smooth movement of a cell through a liquid medium.
  • GO:0017004 The aggregation, arrangement and bonding together of a cytochrome complex. A cytochrome complex is a protein complex in which at least one of the proteins is a cytochrome, i.e. a heme-containing protein involved in catalysis of redox reactions.
  • GO:0002049 The chemical reactions and pathways resulting in the formation of the siderochrome pyoverdine.
  • GO:0043107 Any process involved in the controlled movement of a bacterial cell which is dependent on the presence of type IV pili. Includes social gliding motility and twitching motility.
  • GO:0016020 A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it.
  • GO:0015886 The directed movement of heme, any compound of iron complexed in a porphyrin (tetrapyrrole) ring, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.

Sequence Features

Domain/signature hits from InterPro and related databases.

85 records
Show feature table
Start End DB Term Name
415 420 Phobius CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the cytoplasm.
333 352 Phobius CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the cytoplasm.
353 375 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
4 28 PRINTS PR01411 Cytochrome c-type biogenesis protein CcmF signature
4 28 InterPro IPR003568 Cytochrome c-type biogenesis protein CcmF
113 136 PRINTS PR01411 Cytochrome c-type biogenesis protein CcmF signature
113 136 InterPro IPR003568 Cytochrome c-type biogenesis protein CcmF
395 414 PRINTS PR01411 Cytochrome c-type biogenesis protein CcmF signature
395 414 InterPro IPR003568 Cytochrome c-type biogenesis protein CcmF
629 642 PRINTS PR01411 Cytochrome c-type biogenesis protein CcmF signature
629 642 InterPro IPR003568 Cytochrome c-type biogenesis protein CcmF
352 369 PRINTS PR01411 Cytochrome c-type biogenesis protein CcmF signature
352 369 InterPro IPR003568 Cytochrome c-type biogenesis protein CcmF
190 205 PRINTS PR01411 Cytochrome c-type biogenesis protein CcmF signature
190 205 InterPro IPR003568 Cytochrome c-type biogenesis protein CcmF
314 329 PRINTS PR01411 Cytochrome c-type biogenesis protein CcmF signature
314 329 InterPro IPR003568 Cytochrome c-type biogenesis protein CcmF
447 466 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
1 21 SignalP_EUK SignalP-TM SignalP-TM
376 394 Phobius NON_CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.
449 470 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
275 293 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
277 299 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
53 639 NCBIfam TIGR00353 heme lyase CcmF/NrfE family subunit
53 639 InterPro IPR003568 Cytochrome c-type biogenesis protein CcmF
120 142 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
6 29 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
248 265 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
421 443 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
353 375 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
487 509 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
1 5 Phobius NON_CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.
314 332 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
96 114 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
294 312 Phobius NON_CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.
614 634 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
5 27 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
395 414 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
115 120 Phobius CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the cytoplasm.
91 113 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
206 573 PANTHER PTHR43653 CYTOCHROME C ASSEMBLY PROTEIN-RELATED
206 573 InterPro IPR003567 Cytochrome c-type biogenesis protein
490 512 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
40 62 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
313 332 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
199 209 Phobius CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the cytoplasm.
41 62 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
421 443 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
121 142 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
513 613 Phobius NON_CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.
615 634 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
143 177 Phobius NON_CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.
316 636 Pfam PF16327 Cytochrome c-type biogenesis protein CcmF C-terminal
316 636 InterPro IPR032523 Cytochrome c-type biogenesis protein CcmF, C-terminal
210 230 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
176 198 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
178 198 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
160 182 PRINTS PR01410 Cytochrome c-type biogenesis protein signature
160 182 InterPro IPR003567 Cytochrome c-type biogenesis protein
80 106 PRINTS PR01410 Cytochrome c-type biogenesis protein signature
80 106 InterPro IPR003567 Cytochrome c-type biogenesis protein
132 149 PRINTS PR01410 Cytochrome c-type biogenesis protein signature
132 149 InterPro IPR003567 Cytochrome c-type biogenesis protein
275 295 PRINTS PR01410 Cytochrome c-type biogenesis protein signature
275 295 InterPro IPR003567 Cytochrome c-type biogenesis protein
245 265 PRINTS PR01410 Cytochrome c-type biogenesis protein signature
245 265 InterPro IPR003567 Cytochrome c-type biogenesis protein
211 237 PRINTS PR01410 Cytochrome c-type biogenesis protein signature
211 237 InterPro IPR003567 Cytochrome c-type biogenesis protein
311 330 PRINTS PR01410 Cytochrome c-type biogenesis protein signature
311 330 InterPro IPR003567 Cytochrome c-type biogenesis protein
295 311 PRINTS PR01410 Cytochrome c-type biogenesis protein signature
295 311 InterPro IPR003567 Cytochrome c-type biogenesis protein
231 249 Phobius NON_CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.
471 489 Phobius CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the cytoplasm.
444 448 Phobius NON_CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.
267 274 Phobius CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the cytoplasm.
63 95 Phobius NON_CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.
30 40 Phobius CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the cytoplasm.
390 412 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
635 657 Phobius CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the cytoplasm.
250 266 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
211 233 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
89 296 Pfam PF01578 Cytochrome C assembly protein
89 296 InterPro IPR002541 Cytochrome c assembly protein

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

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Structural evidence

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Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry Method Resolution Chain Coverage Links Status
AlphaFold PA1480
AlphaFold — — full sequence — Viewing
Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET Sticks Spheres Surfaces Druggability Labels Zoom Positions
2 0.879
1 0.353
6 0.219