Protein profile

PA1481

cytochrome c-type biogenesis protein CcmG

Genome: NC_002516.2

Gene: ccmG dsbE PA1481 Structure source: Experimental + AlphaFold UniProt Q9I3N1
Export view
Amino acids 180
Annotations 5
Features 20
PDB binders 3
Druggability 0.391

Overview

Basic information about this protein and its source genome.

Accession
PA1481
Assembly
Pseudomonas aeruginosa PAO1, complete genome
Gene
ccmG dsbE PA1481
Status
annotated
Amino acids
180
Structure source
Experimental + AlphaFold
GO
GO:0030288 The region between the inner (cytoplasmic or plasma) membrane and outer membrane of organisms with two membranes such as Gram negative bacteria. These periplasmic spaces are relatively thick and contain a thin peptidoglycan layer (PGL), also referred to as a thin cell wall. GO:0005886 The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. GO:0015036 Catalysis of the reaction: substrate with reduced sulfide groups = substrate with oxidized disulfide bonds. GO:0016491 Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. GO:0017004 The aggregation, arrangement and bonding together of a cytochrome complex. A cytochrome complex is a protein complex in which at least one of the proteins is a cytochrome, i.e. a heme-containing protein involved in catalysis of redox reactions.

Target profile

Computed evidence for target prioritization.

Human off-target
No hit
Gut microbiome off-target
hit
Essential (DEG)
N
Localization
CytoplasmicMembrane

Selected Druggability evidence

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.391
Structure –
Pocket –

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

5 GO

Gene Ontology (GO)

5
  • GO:0030288 The region between the inner (cytoplasmic or plasma) membrane and outer membrane of organisms with two membranes such as Gram negative bacteria. These periplasmic spaces are relatively thick and contain a thin peptidoglycan layer (PGL), also referred to as a thin cell wall.
  • GO:0005886 The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
  • GO:0015036 Catalysis of the reaction: substrate with reduced sulfide groups = substrate with oxidized disulfide bonds.
  • GO:0016491 Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced.
  • GO:0017004 The aggregation, arrangement and bonding together of a cytochrome complex. A cytochrome complex is a protein complex in which at least one of the proteins is a cytochrome, i.e. a heme-containing protein involved in catalysis of redox reactions.

Sequence Features

Domain/signature hits from InterPro and related databases.

20 records
Show feature table
Start End DB Term Name
6 171 NCBIfam TIGR00385 DsbE family thiol:disulfide interchange protein
34 175 ProSiteProfiles PS51352 Thioredoxin domain profile.
34 175 InterPro IPR013766 Thioredoxin domain
1 5 Phobius SIGNAL_PEPTIDE_N_REGION N-terminal region of a signal peptide.
5 26 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
39 168 PANTHER PTHR42852 THIOL:DISULFIDE INTERCHANGE PROTEIN DSBE
1 26 Phobius SIGNAL_PEPTIDE Signal peptide region
6 171 InterPro IPR004799 Periplasmic protein thiol:disulphide oxidoreductase DsbE
27 180 Phobius NON_CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.
38 163 CDD cd03010 TlpA_like_DsbE
38 163 InterPro IPR004799 Periplasmic protein thiol:disulphide oxidoreductase DsbE
6 21 Phobius SIGNAL_PEPTIDE_H_REGION Hydrophobic region of a signal peptide.
22 26 Phobius SIGNAL_PEPTIDE_C_REGION C-terminal region of a signal peptide.
25 180 Gene3D G3DSA:3.40.30.10 Glutaredoxin
66 84 ProSitePatterns PS00194 Thioredoxin family active site.
66 84 InterPro IPR017937 Thioredoxin, conserved site
37 159 Pfam PF08534 Redoxin
37 159 InterPro IPR013740 Redoxin
41 173 SUPERFAMILY SSF52833 Thioredoxin-like
41 173 InterPro IPR036249 Thioredoxin-like superfamily

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

3D visualization script Full viewer

Loading 3D structure...

Legend High Medium Low

Structural evidence

2 + 1

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry Method Resolution Chain Coverage Links Status
PDB 3KH7
X-ray 1.75 Å A
86.1% 26-180
PDBe RCSB PDBj File
Viewing
PDB 3KH9
X-ray 2.20 Å A
86.1% 26-180
PDBe RCSB PDBj File
Loaded
AlphaFold PA1481
AlphaFold — — full sequence — Loaded
Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET Sticks Spheres Surfaces Druggability Labels Zoom Positions
1 0.391
2 0.21

Ligand evidence

Ligands grouped by evidence source. PDB ligands keep the source crystal visible, and loaded crystals can be opened directly in the structure viewer.

5 records

Structural evidence inferred from similar proteins. The source crystal indicates where the ligand was observed; the UniProt column identifies the homologous protein carrying that ligand.

Show only:
Ligand Source crystal UniProt (homolog) MW · LogP · TPSA Lipinski PAINS SMILES
C6W
2YP6
A0A0H2UPR5 301.3 Da LogP 1.83 TPSA 58.6 ✓ Ro5 ✓ Clean C[N+](C)(C)CCOP(=O)([O-])OCCCc1ccccc1
HED
4HQZ
A0A0H2UPR5 154.3 Da LogP 0.35 TPSA 40.5 ✓ Ro5 ✓ Clean C(CSSCCO)O
MLI
2YP6
A0A0H2UPR5 102.0 Da LogP -3.12 TPSA 80.3 ✓ Ro5 ✓ Clean C(C(=O)[O-])C(=O)[O-]

PDB and ChEMBL records on this protein are shown in full. ChEMBL records from similar proteins are capped at the top 100 per protein (by pchembl) and ZINC at the top 50 (Tanimoto ≥ 0.5). ADME columns are descriptor-based screening flags, not experimental toxicity results.