Protein profile

PA1482

cytochrome c-type biogenesis protein CcmH

Genome: NC_002516.2

Gene: PA1482 ccmH Structure source: Experimental + AlphaFold UniProt Q9I3N0
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Amino acids 155
Annotations 3
Features 18
PDB binders 0
Druggability 0.634

Overview

Basic information about this protein and its source genome.

Accession
PA1482
Assembly
Pseudomonas aeruginosa PAO1, complete genome
Gene
PA1482 ccmH
Status
annotated
Amino acids
155
Structure source
Experimental + AlphaFold
GO
GO:0005886 The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. GO:0046872 Binding to a metal ion. GO:0017004 The aggregation, arrangement and bonding together of a cytochrome complex. A cytochrome complex is a protein complex in which at least one of the proteins is a cytochrome, i.e. a heme-containing protein involved in catalysis of redox reactions.

Target profile

Computed evidence for target prioritization.

Human off-target
No hit
Gut microbiome off-target
hit
Essential (DEG)
Y
Localization
CytoplasmicMembrane

Selected Druggability evidence

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.634
Structure –
Pocket –

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

3 GO

Gene Ontology (GO)

3
  • GO:0005886 The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
  • GO:0046872 Binding to a metal ion.
  • GO:0017004 The aggregation, arrangement and bonding together of a cytochrome complex. A cytochrome complex is a protein complex in which at least one of the proteins is a cytochrome, i.e. a heme-containing protein involved in catalysis of redox reactions.

Sequence Features

Domain/signature hits from InterPro and related databases.

18 records
Show feature table
Start End DB Term Name
104 126 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
20 100 FunFam G3DSA:1.10.8.640:FF:000001 Cytochrome c-type biogenesis protein
104 126 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
1 20 SignalP_EUK SignalP-noTM SignalP-noTM
16 20 Phobius SIGNAL_PEPTIDE_C_REGION C-terminal region of a signal peptide.
3 129 PANTHER PTHR47870 CYTOCHROME C-TYPE BIOGENESIS PROTEIN CCMH
33 98 CDD cd16378 CcmH_N
1 3 Phobius SIGNAL_PEPTIDE_N_REGION N-terminal region of a signal peptide.
17 100 Gene3D G3DSA:1.10.8.640 Cytochrome C biogenesis protein
17 100 InterPro IPR038297 CcmH/CycL/Ccl2/NrfF domain superfamily
21 103 Phobius NON_CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.
1 20 SignalP_GRAM_POSITIVE SignalP-TM SignalP-TM
5 22 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
9 151 Pfam PF03918 Cytochrome C biogenesis protein
9 151 InterPro IPR005616 CcmH/CycL/Ccl2/NrfF family
127 155 Phobius CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the cytoplasm.
1 20 Phobius SIGNAL_PEPTIDE Signal peptide region
4 15 Phobius SIGNAL_PEPTIDE_H_REGION Hydrophobic region of a signal peptide.

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

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Structural evidence

1 + 1

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry Method Resolution Chain Coverage Links Status
PDB 2HL7
X-ray 1.70 Å A
51.6% 21-100
PDBe RCSB PDBj File
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AlphaFold PA1482
AlphaFold — — full sequence — Loaded
Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET Sticks Spheres Surfaces Druggability Labels Zoom Positions
1 0.634
2 0.58

Pockets (P2RANK)

Showing top-ranked P2Rank candidates by probability. Probability is color-coded per P2Rank calibration: high (≥ 0.5), medium (0.2 – 0.49), low (< 0.2).

P2RANK Sticks Spheres Surfaces Score Probability Labels Zoom Positions
1 0.82 0.003