Target Pathogen

Overview

Basic information about this protein and its source genome.

Accession: PA1483
Assembly: Pseudomonas aeruginosa PAO1, complete genome
Gene: PA1483 cycH
Status: annotated
Amino acids: 407
Structure source: AlphaFold

GO

GO:0005886 The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. GO:0017004 The aggregation, arrangement and bonding together of a cytochrome complex. A cytochrome complex is a protein complex in which at least one of the proteins is a cytochrome, i.e. a heme-containing protein involved in catalysis of redox reactions. GO:0005515 Binding to a protein.

Target profile

Computed evidence for target prioritization.

Human off-target: No hit
Gut microbiome off-target: hit
Essential (DEG): N
Localization: CytoplasmicMembrane

Selected Druggability evidence

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.875

Structure –

Pocket –

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

3 GO

Gene Ontology (GO)

3

GO:0005886 The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
GO:0017004 The aggregation, arrangement and bonding together of a cytochrome complex. A cytochrome complex is a protein complex in which at least one of the proteins is a cytochrome, i.e. a heme-containing protein involved in catalysis of redox reactions.
GO:0005515 Binding to a protein.

Sequence Features

Domain/signature hits from InterPro and related databases.

23 records

Show feature table

Start	End	DB	Term	Name
1	31	SignalP_EUK	SignalP-TM	SignalP-TM
93	113	Phobius	TRANSMEMBRANE	Region of a membrane-bound protein predicted to be embedded in the membrane.
133	277	Gene3D	G3DSA:1.25.40.10	Tetratricopeptide repeat domain
133	277	InterPro	IPR011990	Tetratricopeptide-like helical domain superfamily
1	5	Phobius	SIGNAL_PEPTIDE_N_REGION	N-terminal region of a signal peptide.
150	183	ProSiteProfiles	PS50005	TPR repeat profile.
150	183	InterPro	IPR019734	Tetratricopeptide repeat
93	115	TMHMM	TMhelix	Region of a membrane-bound protein predicted to be embedded in the membrane.
6	24	Phobius	SIGNAL_PEPTIDE_H_REGION	Hydrophobic region of a signal peptide.
1	94	PANTHER	PTHR47870	CYTOCHROME C-TYPE BIOGENESIS PROTEIN CCMH
1	31	Phobius	SIGNAL_PEPTIDE	Signal peptide region
32	92	Phobius	NON_CYTOPLASMIC_DOMAIN	Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.
388	407	MobiDBLite	mobidb-lite	consensus disorder prediction
25	31	Phobius	SIGNAL_PEPTIDE_C_REGION	C-terminal region of a signal peptide.
4	116	NCBIfam	TIGR03142	c-type cytochrome biogenesis protein CcmI
4	116	InterPro	IPR017560	Cytochrome c-type biogenesis protein CcmI
4	26	TMHMM	TMhelix	Region of a membrane-bound protein predicted to be embedded in the membrane.
150	183	SMART	SM00028	tpr_5
221	254	SMART	SM00028	tpr_5
221	254	InterPro	IPR019734	Tetratricopeptide repeat
114	407	Phobius	CYTOPLASMIC_DOMAIN	Region of a membrane-bound protein predicted to be outside the membrane, in the cytoplasm.
142	284	SUPERFAMILY	SSF48452	TPR-like
142	284	InterPro	IPR011990	Tetratricopeptide-like helical domain superfamily

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

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Structural evidence

0 + 1

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry	Method	Resolution	Chain	Coverage	Links	Status
AlphaFold PA1483	AlphaFold	—	—	full sequence	—	Viewing

Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET	Sticks	Spheres	Surfaces	Druggability	Labels	Zoom	Positions
3				0.875
5				0.453
15				0.451

PA1483