Target Pathogen

Overview

Basic information about this protein and its source genome.

Accession: PA1484
Assembly: Pseudomonas aeruginosa PAO1, complete genome
Gene: PA1484
Status: annotated
Amino acids: 268
Structure source: AlphaFold

GO

GO:0003677 Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid). GO:0003700 A transcription regulator activity that modulates transcription of gene sets via selective and non-covalent binding to a specific double-stranded genomic DNA sequence (sometimes referred to as a motif) within a cis-regulatory region. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units, and include bacterial operons. GO:0006355 Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription.

Target profile

Computed evidence for target prioritization.

Human off-target: No hit
Gut microbiome off-target: hit
Essential (DEG): N
Localization: Cytoplasmic

Selected Druggability evidence

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.899

Structure –

Pocket –

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

3 GO

Gene Ontology (GO)

3

GO:0003677 Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid).
GO:0003700 A transcription regulator activity that modulates transcription of gene sets via selective and non-covalent binding to a specific double-stranded genomic DNA sequence (sometimes referred to as a motif) within a cis-regulatory region. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units, and include bacterial operons.
GO:0006355 Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription.

Sequence Features

Domain/signature hits from InterPro and related databases.

19 records

Show feature table

Start	End	DB	Term	Name
201	255	Pfam	PF00196	Bacterial regulatory proteins, luxR family
201	255	InterPro	IPR000792	Transcription regulator LuxR, C-terminal
203	259	CDD	cd06170	LuxR_C_like
203	259	InterPro	IPR000792	Transcription regulator LuxR, C-terminal
165	261	Gene3D	G3DSA:1.10.10.10	-
165	261	InterPro	IPR036388	Winged helix-like DNA-binding domain superfamily
196	261	ProSiteProfiles	PS50043	LuxR-type HTH domain profile.
196	261	InterPro	IPR000792	Transcription regulator LuxR, C-terminal
191	259	SUPERFAMILY	SSF46894	C-terminal effector domain of the bipartite response regulators
191	259	InterPro	IPR016032	Signal transduction response regulator, C-terminal effector
217	233	PRINTS	PR00038	LuxR bacterial regulatory protein HTH signature
217	233	InterPro	IPR000792	Transcription regulator LuxR, C-terminal
203	217	PRINTS	PR00038	LuxR bacterial regulatory protein HTH signature
203	217	InterPro	IPR000792	Transcription regulator LuxR, C-terminal
233	245	PRINTS	PR00038	LuxR bacterial regulatory protein HTH signature
233	245	InterPro	IPR000792	Transcription regulator LuxR, C-terminal
66	258	PANTHER	PTHR44688	-
200	257	SMART	SM00421	luxrmega5
200	257	InterPro	IPR000792	Transcription regulator LuxR, C-terminal

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

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Structural evidence

0 + 1

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry	Method	Resolution	Chain	Coverage	Links	Status
AlphaFold PA1484	AlphaFold	—	—	full sequence	—	Viewing

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Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET	Sticks	Spheres	Surfaces	Druggability	Labels	Zoom	Positions
1				0.899
2				0.303

PA1484