Target Pathogen

Overview

Basic information about this protein and its source genome.

Accession: PA1490
Assembly: Pseudomonas aeruginosa PAO1, complete genome
Gene: PA1490
Status: annotated
Amino acids: 258
Structure source: AlphaFold

GO

GO:0000987 Binding to a specific upstream regulatory DNA sequence (transcription factor recognition sequence or binding site, located in cis relative to the transcription start site (i.e., on the same strand of DNA) of a gene transcribed by some RNA polymerase. Cis-regulatory sites are often referred to as a sequence motifs, enhancers, or silencers. GO:0098531 A DNA-binding transcription factor activity regulated by binding to a ligand and that modulates the transcription of specific genes and gene sets. Examples include the lac and trp repressors in E.coli and steroid hormone receptors. GO:0006355 Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription. GO:0003700 A transcription regulator activity that modulates transcription of gene sets via selective and non-covalent binding to a specific double-stranded genomic DNA sequence (sometimes referred to as a motif) within a cis-regulatory region. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units, and include bacterial operons.

Target profile

Computed evidence for target prioritization.

Human off-target: No hit
Gut microbiome off-target: hit
Essential (DEG): N
Localization: Cytoplasmic

Selected Druggability evidence

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.509

Structure –

Pocket –

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

4 GO

Gene Ontology (GO)

4

GO:0000987 Binding to a specific upstream regulatory DNA sequence (transcription factor recognition sequence or binding site, located in cis relative to the transcription start site (i.e., on the same strand of DNA) of a gene transcribed by some RNA polymerase. Cis-regulatory sites are often referred to as a sequence motifs, enhancers, or silencers.
GO:0098531 A DNA-binding transcription factor activity regulated by binding to a ligand and that modulates the transcription of specific genes and gene sets. Examples include the lac and trp repressors in E.coli and steroid hormone receptors.
GO:0006355 Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription.
GO:0003700 A transcription regulator activity that modulates transcription of gene sets via selective and non-covalent binding to a specific double-stranded genomic DNA sequence (sometimes referred to as a motif) within a cis-regulatory region. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units, and include bacterial operons.

Sequence Features

Domain/signature hits from InterPro and related databases.

25 records

Show feature table

Start	End	DB	Term	Name
73	232	SMART	SM01134	DeoRC_2
38	56	PRINTS	PR00037	LacR bacterial regulatory protein HTH signature
38	56	InterPro	IPR001034	DeoR-type HTH domain
24	38	PRINTS	PR00037	LacR bacterial regulatory protein HTH signature
24	38	InterPro	IPR001034	DeoR-type HTH domain
3	58	ProSiteProfiles	PS51000	DeoR-type HTH domain profile.
3	58	InterPro	IPR001034	DeoR-type HTH domain
3	73	Gene3D	G3DSA:1.10.10.10	-
3	73	InterPro	IPR036388	Winged helix-like DNA-binding domain superfamily
75	232	SUPERFAMILY	SSF100950	NagB/RpiA/CoA transferase-like
75	232	InterPro	IPR037171	NagB/RpiA transferase-like
6	40	ProSitePatterns	PS00894	DeoR-type HTH domain signature.
6	40	InterPro	IPR018356	Transcription regulator, HTH DeoR-type, conserved site
1	250	PANTHER	PTHR30363	HTH-TYPE TRANSCRIPTIONAL REGULATOR SRLR-RELATED
4	77	SUPERFAMILY	SSF46785	Winged helix DNA-binding domain
4	77	InterPro	IPR036390	Winged helix DNA-binding domain superfamily
6	59	Pfam	PF08220	DeoR-like helix-turn-helix domain
6	59	InterPro	IPR001034	DeoR-type HTH domain
5	55	CDD	cd00090	HTH_ARSR
5	55	InterPro	IPR011991	ArsR-like helix-turn-helix domain
6	58	SMART	SM00420	deor2
6	58	InterPro	IPR001034	DeoR-type HTH domain
75	231	Pfam	PF00455	DeoR C terminal sensor domain
75	231	InterPro	IPR014036	DeoR C-terminal sensor domain
74	226	Gene3D	G3DSA:3.40.50.1360	-

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

Loading 3D structure...

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Structural evidence

0 + 1

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry	Method	Resolution	Chain	Coverage	Links	Status
AlphaFold PA1490	AlphaFold	—	—	full sequence	—	Viewing

Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET	Sticks	Spheres	Surfaces	Druggability	Labels	Zoom	Positions
3				0.509
4				0.275

PA1490