Protein profile

PA1496

potassium channel

Genome: NC_002516.2

Gene: PA1496 Structure source: AlphaFold UniProt Q9I3L6
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Amino acids 283
Annotations 8
Features 35
PDB binders 4
Druggability 0.511

Overview

Basic information about this protein and its source genome.

Accession
PA1496
Assembly
Pseudomonas aeruginosa PAO1, complete genome
Gene
PA1496
Status
annotated
Amino acids
283
Structure source
AlphaFold
GO
GO:0016020 A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. GO:0008076 A protein complex that forms a transmembrane channel through which potassium ions may cross a cell membrane in response to changes in membrane potential. GO:0005249 Enables the transmembrane transfer of a potassium ion by a voltage-gated channel. A voltage-gated channel is a channel whose open state is dependent on the voltage across the membrane in which it is embedded. GO:0001508 A process in which membrane potential cycles through a depolarizing spike, triggered in response to depolarization above some threshold, followed by repolarization. This cycle is driven by the flow of ions through various voltage gated channels with different thresholds and ion specificities. GO:0071805 A process in which a potassium ion is transported from one side of a membrane to the other. GO:0006811 The directed movement of a monoatomic ion into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Monatomic ions (also called simple ions) are ions consisting of exactly one atom.

Target profile

Computed evidence for target prioritization.

Human off-target
hit
Human identity (%)
46.154
Human E-value
5.01e-07
Gut microbiome off-target
hit
Essential (DEG)
N
Localization
CytoplasmicMembrane

Selected Druggability evidence

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.511
Structure –
Pocket –

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

8 GO

Gene Ontology (GO)

8
  • GO:0016020 A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it.
  • GO:0008076 A protein complex that forms a transmembrane channel through which potassium ions may cross a cell membrane in response to changes in membrane potential.
  • GO:0005249 Enables the transmembrane transfer of a potassium ion by a voltage-gated channel. A voltage-gated channel is a channel whose open state is dependent on the voltage across the membrane in which it is embedded.
  • GO:0001508 A process in which membrane potential cycles through a depolarizing spike, triggered in response to depolarization above some threshold, followed by repolarization. This cycle is driven by the flow of ions through various voltage gated channels with different thresholds and ion specificities.
  • GO:0071805 A process in which a potassium ion is transported from one side of a membrane to the other.
  • GO:0006811 The directed movement of a monoatomic ion into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Monatomic ions (also called simple ions) are ions consisting of exactly one atom.
  • GO:0055085 The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other.
  • GO:0005216 Enables the facilitated diffusion of a monoatomic ion (by an energy-independent process) by passage through a transmembrane aqueous pore or channel without evidence for a carrier-mediated mechanism. May be either selective (it enables passage of a specific ion only) or non-selective (it enables passage of two or more ions of same charge but different size).

Sequence Features

Domain/signature hits from InterPro and related databases.

35 records
Show feature table
Start End DB Term Name
26 44 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
151 172 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
151 245 FunFam G3DSA:1.10.287.70:FF:000164 Voltage-sensitive potassium channel
131 150 Phobius CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the cytoplasm.
151 248 Gene3D G3DSA:1.10.287.70 -
185 202 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
29 236 PANTHER PTHR11537 VOLTAGE-GATED POTASSIUM CHANNEL
86 106 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
207 229 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
26 235 Pfam PF00520 Ion transport protein
26 235 InterPro IPR005821 Ion transport domain
151 172 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
210 230 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
173 209 Phobius NON_CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.
22 150 Gene3D G3DSA:1.20.120.350 -
22 150 InterPro IPR027359 Voltage-dependent channel domain superfamily
85 107 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
231 283 Phobius CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the cytoplasm.
59 82 PRINTS PR00169 Potassium channel signature
85 105 PRINTS PR00169 Potassium channel signature
121 147 PRINTS PR00169 Potassium channel signature
150 173 PRINTS PR00169 Potassium channel signature
208 234 PRINTS PR00169 Potassium channel signature
17 45 PRINTS PR00169 Potassium channel signature
179 201 PRINTS PR00169 Potassium channel signature
112 130 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
75 85 Phobius CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the cytoplasm.
56 74 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
29 46 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
45 55 Phobius NON_CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.
107 111 Phobius NON_CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.
22 150 FunFam G3DSA:1.20.120.350:FF:000076 Ion transporter, putative
24 234 SUPERFAMILY SSF81324 Voltage-gated potassium channels
1 25 Phobius CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the cytoplasm.
56 78 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

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Structural evidence

0 + 1

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry Method Resolution Chain Coverage Links Status
AlphaFold PA1496
AlphaFold — — full sequence — Viewing
Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET Sticks Spheres Surfaces Druggability Labels Zoom Positions
4 0.511
3 0.233

Ligand evidence

Ligands grouped by evidence source. PDB ligands keep the source crystal visible, and loaded crystals can be opened directly in the structure viewer.

63 records

Structural evidence inferred from similar proteins. The source crystal indicates where the ligand was observed; the UniProt column identifies the homologous protein carrying that ligand.

Show only:
Ligand Source crystal UniProt (homolog) MW · LogP · TPSA Lipinski PAINS SMILES
FBX
7BYM
P56696 303.3 Da LogP 3.59 TPSA 76.4 ✓ Ro5 ✓ Clean CCOC(=O)Nc1ccc(cc1N)NCc2ccc(cc2)F
GB9
7CR1
O43526 250.7 Da LogP 3.13 TPSA 42.0 ✓ Ro5 ✓ Clean c1cc(ccc1C(=O)Nc2ccc(nc2)Cl)F
PGW
5WIE
P63141 749.0 Da LogP 10.45 TPSA 148.8 2 viol. ✓ Clean CCCCCCCCCCCCCCCC(=O)OC[C@H](CO[P@@](=O)(O)OC[C@…
PT5
7BYL
P56696 1047.1 Da LogP 9.40 TPSA 302.6 4 viol. ✓ Clean CCCCCCCCCCCCCCCCCC(=O)OC[C@H](COP(=O)(O)O[C@@H]…

PDB and ChEMBL records on this protein are shown in full. ChEMBL records from similar proteins are capped at the top 100 per protein (by pchembl) and ZINC at the top 50 (Tanimoto ≥ 0.5). ADME columns are descriptor-based screening flags, not experimental toxicity results.