Protein profile

PA1499

hypothetical protein

Genome: NC_002516.2

Gene: PA1499 Structure source: AlphaFold UniProt Q9I3L3
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Amino acids 421
Annotations 3
Features 13
PDB binders 0
Druggability 0.761

Overview

Basic information about this protein and its source genome.

Accession
PA1499
Assembly
Pseudomonas aeruginosa PAO1, complete genome
Gene
PA1499
Status
annotated
Amino acids
421
Structure source
AlphaFold
GO
GO:0005737 The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. GO:0005524 Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. GO:0008887 Catalysis of the reaction: D-glycerate + ATP = 3-phospho-D-glycerate + ADP + 2 H+.

Target profile

Computed evidence for target prioritization.

Human off-target
hit
Human identity (%)
44.056
Human E-value
2.0800000000000004e-27
Gut microbiome off-target
hit
Essential (DEG)
N
Localization
Cytoplasmic

Selected Druggability evidence

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.761
Structure –
Pocket –

Sequence

Primary amino-acid sequence viewer.

MSTDPRAFLTELFNTAVAAGHPYQVLADHLPEDRSGRAIVIGAGKAAGAMAEVVEKHWQGEIQGLVVAPYRYGAQCSRIEVVEASHPVPDDAGERVARRVLELISGLNESDRVIFLLSGGGSALLSLPAEGIGLADKQAVNKALLKSGAAIGEMNCVRKHLSAIKGGRLAKACWPASVYTYAISDVPGDEATVIASGPSVGDPTTSADALAILKRYAIDVPQNVLDWLADPRSETVKPDDPCLARSHFQLIATPQNALDAAAVKCRAAGFSTLILGDLEGEAREVAKVHAGIARQIRKHGQPLAAPCVILSGGETTVTVRGNGRGGRNAEFLLSLTAELKGEPNIWALAGDTDGIDGSEDNAGALMTPCSHARGEKAGLKIRDELYDNNGYGYFQALGDLLVTGPTRTNVNDFRAILILES

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

3 GO

Gene Ontology (GO)

3
  • GO:0005737 The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
  • GO:0005524 Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
  • GO:0008887 Catalysis of the reaction: D-glycerate + ATP = 3-phospho-D-glycerate + ADP + 2 H+.

Sequence Features

Domain/signature hits from InterPro and related databases.

13 records
Show feature table
Start End DB Term Name
253 413 Gene3D G3DSA:3.40.1480.10 MOFRL domain
253 413 InterPro IPR037035 Glycerate kinase-like, C-terminal domain superfamily
32 252 FunFam G3DSA:3.40.50.10180:FF:000001 Glycerate kinase
35 252 Gene3D G3DSA:3.40.50.10180 -
35 252 InterPro IPR038614 Glycerate kinase, N-terminal domain superfamily
253 414 FunFam G3DSA:3.40.1480.10:FF:000002 Glycerate kinase
4 418 PANTHER PTHR12227 GLYCERATE KINASE
4 418 InterPro IPR039760 MOFRL domain-containing protein
307 412 Pfam PF05161 MOFRL family
307 412 InterPro IPR007835 MOFRL domain
9 228 Pfam PF13660 Domain of unknown function (DUF4147)
9 228 InterPro IPR025286 MOFRL-associated domain
4 418 SUPERFAMILY SSF82544 GckA/TtuD-like

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

3D visualization script Full viewer

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Structural evidence

0 + 1

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry Method Resolution Chain Coverage Links Status
AlphaFold PA1499
AlphaFold — — full sequence — Viewing
Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET Sticks Spheres Surfaces Druggability Labels Zoom Positions
2 0.761