Target Pathogen

Overview

Basic information about this protein and its source genome.

Accession: PA1511
Assembly: Pseudomonas aeruginosa PAO1, complete genome
Gene: vgrG2a PA1511
Status: annotated
Amino acids: 842
Structure source: AlphaFold

GO

GO:0033104 A complex of proteins that permits the transfer of proteins into the extracellular milieu or directly into host cells via the type VI secretion system. Proteins secreted by this complex do not require an N-terminal signal sequence. GO:0033103 The process in which proteins are transferred into the extracellular milieu or directly into host cells by the type VI secretion system. Proteins secreted by this system do not require an N-terminal signal sequence.

Target profile

Computed evidence for target prioritization.

Human off-target: No hit
Gut microbiome off-target: hit
Essential (DEG): N
Localization: Cytoplasmic

Selected Druggability evidence

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.547

Structure –

Pocket –

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

2 GO

Gene Ontology (GO)

2

GO:0033104 A complex of proteins that permits the transfer of proteins into the extracellular milieu or directly into host cells via the type VI secretion system. Proteins secreted by this complex do not require an N-terminal signal sequence.
GO:0033103 The process in which proteins are transferred into the extracellular milieu or directly into host cells by the type VI secretion system. Proteins secreted by this system do not require an N-terminal signal sequence.

Sequence Features

Domain/signature hits from InterPro and related databases.

22 records

Show feature table

Start	End	DB	Term	Name
475	581	Pfam	PF13296	Putative type VI secretion system Rhs element Vgr
475	581	InterPro	IPR028244	Putative type VI secretion system, Rhs element associated Vgr domain
9	493	NCBIfam	TIGR03361	type VI secretion system tip protein TssI/VgrG N-terminal domain
9	493	InterPro	IPR017847	Type VI secretion system, RhsGE-associated Vgr family subset
27	327	Pfam	PF05954	Phage tail baseplate hub (GPD)
221	284	Gene3D	G3DSA:4.10.220.110	-
19	502	NCBIfam	TIGR01646	type VI secretion system tip protein VgrG
19	502	InterPro	IPR006533	Type VI secretion system, RhsGE-associated Vgr protein
358	456	Gene3D	G3DSA:2.40.50.230	-
358	456	InterPro	IPR037026	Vgr protein, OB-fold domain superfamily
197	365	SUPERFAMILY	SSF69279	Phage tail proteins
21	328	Gene3D	G3DSA:2.30.110.50	-
364	451	SUPERFAMILY	SSF69255	gp5 N-terminal domain-like
386	453	Pfam	PF04717	Type VI secretion system/phage-baseplate injector OB domain
386	453	InterPro	IPR006531	Gp5/Type VI secretion system Vgr protein, OB-fold domain
3	724	PANTHER	PTHR32305	-
442	493	SUPERFAMILY	SSF69349	Phage fibre proteins
615	759	Pfam	PF10106	Uncharacterized protein conserved in bacteria (DUF2345)
615	759	InterPro	IPR018769	Type VI secretion system spike protein VgrG2, domain of unknown function DUF2345
9	182	SUPERFAMILY	SSF69279	Phage tail proteins
96	187	Gene3D	G3DSA:3.55.50.10	-
584	621	MobiDBLite	mobidb-lite	consensus disorder prediction

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

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Structural evidence

0 + 1

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry	Method	Resolution	Chain	Coverage	Links	Status
AlphaFold PA1511	AlphaFold	—	—	full sequence	—	Viewing

Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET	Sticks	Spheres	Surfaces	Druggability	Labels	Zoom	Positions
1				0.547

PA1511