Target Pathogen

Overview

Basic information about this protein and its source genome.

Accession: PA1514
Assembly: Pseudomonas aeruginosa PAO1, complete genome
Gene: PA1514 allA
Status: annotated
Amino acids: 169
Structure source: AlphaFold

EC

4.3.2.3

GO

GO:0004848 Catalysis of the reaction: (S)-ureidoglycolate + H2O + 2 H+ = CO2 + glyoxylate + 2 NH4. GO:0050385 Catalysis of the reaction: (S)-ureidoglycolate = glyoxylate + urea. GO:0000256 The chemical reactions and pathways resulting in the breakdown of allantoin, (2,5-dioxo-4-imidazolidinyl)urea. GO:0006145 The chemical reactions and pathways resulting in the breakdown of purine nucleobases, one of the two classes of nitrogen-containing ring compounds found in DNA and RNA, which include adenine and guanine.

Target profile

Computed evidence for target prioritization.

Human off-target: No hit
Gut microbiome off-target: hit
Essential (DEG): Y
Localization: Unknown

Selected Druggability evidence

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.78

Structure –

Pocket –

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

1 EC 4 GO

Enzyme Commission (EC)

1

4.3.2.3

Gene Ontology (GO)

4

GO:0004848 Catalysis of the reaction: (S)-ureidoglycolate + H2O + 2 H+ = CO2 + glyoxylate + 2 NH4.
GO:0050385 Catalysis of the reaction: (S)-ureidoglycolate = glyoxylate + urea.
GO:0000256 The chemical reactions and pathways resulting in the breakdown of allantoin, (2,5-dioxo-4-imidazolidinyl)urea.
GO:0006145 The chemical reactions and pathways resulting in the breakdown of purine nucleobases, one of the two classes of nitrogen-containing ring compounds found in DNA and RNA, which include adenine and guanine.

Sequence Features

Domain/signature hits from InterPro and related databases.

15 records

Show feature table

Start	End	DB	Term	Name
2	162	PIRSF	PIRSF017306	Ureidoglycolate_hydrolase
2	162	InterPro	IPR007247	Ureidoglycolate lyase
3	167	PANTHER	PTHR21221	UREIDOGLYCOLATE HYDROLASE
3	167	InterPro	IPR007247	Ureidoglycolate lyase
1	162	SUPERFAMILY	SSF51182	RmlC-like cupins
1	162	InterPro	IPR011051	RmlC-like cupin domain superfamily
2	163	Hamap	MF_00616	Ureidoglycolate lyase [allA].
2	163	InterPro	IPR023525	Ureidoglycolate lyase, bacterial
54	143	CDD	cd20298	cupin_UAH
54	143	InterPro	IPR047233	Ureidoglycolate amidohydrolase, cupin domain
1	163	FunFam	G3DSA:2.60.120.480:FF:000001	Ureidoglycolate lyase
1	169	Gene3D	G3DSA:2.60.120.480	Ureidoglycolate hydrolase
1	169	InterPro	IPR024060	Ureidoglycolate lyase domain superfamily
2	158	Pfam	PF04115	Ureidoglycolate lyase
2	158	InterPro	IPR007247	Ureidoglycolate lyase

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

Loading 3D structure...

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Structural evidence

0 + 1

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry	Method	Resolution	Chain	Coverage	Links	Status
AlphaFold PA1514	AlphaFold	—	—	full sequence	—	Viewing

Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET	Sticks	Spheres	Surfaces	Druggability	Labels	Zoom	Positions
1				0.78

Ligand evidence

Ligands grouped by evidence source. PDB ligands keep the source crystal visible, and loaded crystals can be opened directly in the structure viewer.

1 records

Highest-confidence structural evidence: ligands co-crystallized with this exact protein. If the source PDB is loaded in TPW, use Open crystal to inspect it in the structure viewer.

No PDB structure with a co-crystallized ligand found for this exact protein.

Structural evidence inferred from similar proteins. The source crystal indicates where the ligand was observed; the UniProt column identifies the homologous protein carrying that ligand.

Ligand	Source crystal	UniProt (homolog)	MW · LogP · TPSA	Lipinski	PAINS	SMILES
GLV	1YQC	P63486	74.0 Da LogP -0.73 TPSA 54.4	✓ Ro5	✓ Clean	`C(=O)C(=O)O`

Experimental bioactivity from ChEMBL measured directly on this protein. Score = pchembl (−log Ki/IC₅₀; higher = more potent).

No ChEMBL bioactivity data found for this exact protein.

Bioactivity inferred from similar proteins in ChEMBL. Score = pchembl (−log Ki/IC₅₀; higher = more potent).

No ChEMBL hits found through similar proteins.

Proposed virtual-screening candidates from ZINC. Score = Tanimoto similarity to a known binder (0–1; higher = more similar).

No virtual-screening candidates for this protein.

PDB and ChEMBL records on this protein are shown in full. ChEMBL records from similar proteins are capped at the top 100 per protein (by pchembl) and ZINC at the top 50 (Tanimoto ≥ 0.5). ADME columns are descriptor-based screening flags, not experimental toxicity results.

PA1514