Protein profile

PA1515

allantoicase

Genome: NC_002516.2

Gene: alc PA1515 Structure source: AlphaFold UniProt Q9I3J8
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Amino acids 332
Annotations 4
Features 20
PDB binders 0
Druggability 0.594

Overview

Basic information about this protein and its source genome.

Accession
PA1515
Assembly
Pseudomonas aeruginosa PAO1, complete genome
Gene
alc PA1515
Status
annotated
Amino acids
332
Structure source
AlphaFold
EC
3.5.3.4
GO
GO:0004037 Catalysis of the reaction: allantoate + H2O = (S)-ureidoglycolate + urea. GO:0000256 The chemical reactions and pathways resulting in the breakdown of allantoin, (2,5-dioxo-4-imidazolidinyl)urea. GO:0006144 The chemical reactions and pathways involving purine nucleobases, one of the two classes of nitrogen-containing ring compounds found in DNA and RNA, which include adenine and guanine.

Target profile

Computed evidence for target prioritization.

Human off-target
hit
Human identity (%)
36.413
Human E-value
2.54e-78
Gut microbiome off-target
hit
Essential (DEG)
N
Localization
Cytoplasmic

Selected Druggability evidence

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.594
Structure –
Pocket –

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

1 EC 3 GO

Enzyme Commission (EC)

1

Gene Ontology (GO)

3
  • GO:0004037 Catalysis of the reaction: allantoate + H2O = (S)-ureidoglycolate + urea.
  • GO:0000256 The chemical reactions and pathways resulting in the breakdown of allantoin, (2,5-dioxo-4-imidazolidinyl)urea.
  • GO:0006144 The chemical reactions and pathways involving purine nucleobases, one of the two classes of nitrogen-containing ring compounds found in DNA and RNA, which include adenine and guanine.

Sequence Features

Domain/signature hits from InterPro and related databases.

20 records
Show feature table
Start End DB Term Name
20 165 Pfam PF03561 Allantoicase repeat
20 165 InterPro IPR015908 Allantoicase domain
187 329 Pfam PF03561 Allantoicase repeat
187 329 InterPro IPR015908 Allantoicase domain
4 329 PANTHER PTHR12045 ALLANTOICASE
4 329 InterPro IPR005164 Allantoicase
177 329 SUPERFAMILY SSF49785 Galactose-binding domain-like
177 329 InterPro IPR008979 Galactose-binding-like domain superfamily
11 328 NCBIfam TIGR02961 allantoicase
11 328 InterPro IPR005164 Allantoicase
169 331 FunFam G3DSA:2.60.120.260:FF:000059 Probable allantoicase
169 332 Gene3D G3DSA:2.60.120.260 -
1 168 Gene3D G3DSA:2.60.120.260 -
1 167 FunFam G3DSA:2.60.120.260:FF:000090 Probable allantoicase
6 168 SUPERFAMILY SSF49785 Galactose-binding domain-like
6 168 InterPro IPR008979 Galactose-binding-like domain superfamily
1 331 PIRSF PIRSF016516 Allantoicase
1 331 InterPro IPR005164 Allantoicase
9 330 Hamap MF_00813 Probable allantoicase [alc].
9 330 InterPro IPR005164 Allantoicase

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

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Structural evidence

0 + 1

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry Method Resolution Chain Coverage Links Status
AlphaFold PA1515
AlphaFold — — full sequence — Viewing
Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET Sticks Spheres Surfaces Druggability Labels Zoom Positions
1 0.594