Protein profile

PA1516

hypothetical protein

Genome: NC_002516.2

Gene: PA1516 Structure source: AlphaFold UniProt Q9I3J7
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Amino acids 171
Annotations 6
Features 9
PDB binders 3
Druggability 0.444

Overview

Basic information about this protein and its source genome.

Accession
PA1516
Assembly
Pseudomonas aeruginosa PAO1, complete genome
Gene
PA1516
Status
annotated
Amino acids
171
Structure source
AlphaFold
EC
4.1.1.97
GO
GO:0005777 A small organelle enclosed by a single membrane, and found in most eukaryotic cells. Contains peroxidases and other enzymes involved in a variety of metabolic processes including free radical detoxification, lipid catabolism and biosynthesis, and hydrogen peroxide metabolism. GO:0051997 Catalysis of the reaction: 5-hydroxy-2-oxo-4-ureido-2,5-dihydro-1H imidazole-5-carboxylate + H+ = S-allantoin + CO2. GO:0000255 The chemical reactions and pathways involving allantoin, (2,5-dioxo-4-imidazolidinyl)urea, an intermediate or end product of purine catabolism. GO:0006144 The chemical reactions and pathways involving purine nucleobases, one of the two classes of nitrogen-containing ring compounds found in DNA and RNA, which include adenine and guanine. GO:0019628 The chemical reactions and pathways resulting in the breakdown of urate, the anion of uric acid, 2,6,8-trioxypurine.

Target profile

Computed evidence for target prioritization.

Human off-target
hit
Human identity (%)
34.839
Human E-value
2.13e-26
Gut microbiome off-target
hit
Essential (DEG)
N
Localization
Cytoplasmic

Selected Druggability evidence

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.444
Structure –
Pocket –

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

1 EC 5 GO

Enzyme Commission (EC)

1

Gene Ontology (GO)

5
  • GO:0005777 A small organelle enclosed by a single membrane, and found in most eukaryotic cells. Contains peroxidases and other enzymes involved in a variety of metabolic processes including free radical detoxification, lipid catabolism and biosynthesis, and hydrogen peroxide metabolism.
  • GO:0051997 Catalysis of the reaction: 5-hydroxy-2-oxo-4-ureido-2,5-dihydro-1H imidazole-5-carboxylate + H+ = S-allantoin + CO2.
  • GO:0000255 The chemical reactions and pathways involving allantoin, (2,5-dioxo-4-imidazolidinyl)urea, an intermediate or end product of purine catabolism.
  • GO:0006144 The chemical reactions and pathways involving purine nucleobases, one of the two classes of nitrogen-containing ring compounds found in DNA and RNA, which include adenine and guanine.
  • GO:0019628 The chemical reactions and pathways resulting in the breakdown of urate, the anion of uric acid, 2,6,8-trioxypurine.

Sequence Features

Domain/signature hits from InterPro and related databases.

9 records
Show feature table
Start End DB Term Name
11 171 SUPERFAMILY SSF158694 UraD-Like
11 171 InterPro IPR036778 Oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline decarboxylase superfamily
3 171 PANTHER PTHR43466 2-OXO-4-HYDROXY-4-CARBOXY-5-UREIDOIMIDAZOLINE DECARBOXYLASE-RELATED
11 169 Pfam PF09349 OHCU decarboxylase
11 169 InterPro IPR018020 Oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline decarboxylase
13 171 NCBIfam TIGR03164 2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline decarboxylase
13 171 InterPro IPR017580 2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline decarboxylase, type 1
8 171 Gene3D G3DSA:1.10.3330.10 -
8 171 InterPro IPR036778 Oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline decarboxylase superfamily

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

3D visualization script Full viewer

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Structural evidence

0 + 1

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry Method Resolution Chain Coverage Links Status
AlphaFold PA1516
AlphaFold — — full sequence — Viewing
Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET Sticks Spheres Surfaces Druggability Labels Zoom Positions
2 0.444
1 0.29

Ligand evidence

Ligands grouped by evidence source. PDB ligands keep the source crystal visible, and loaded crystals can be opened directly in the structure viewer.

8 records

Structural evidence inferred from similar proteins. The source crystal indicates where the ligand was observed; the UniProt column identifies the homologous protein carrying that ligand.

Show only:
Ligand Source crystal UniProt (homolog) MW · LogP · TPSA Lipinski PAINS SMILES
2AL
2O73
A1L259 156.1 Da LogP -1.70 TPSA 113.6 ✓ Ro5 ✓ Clean C1(=O)C(=NC(=O)N1)NC(=O)N
3AL
2Q37
Q9LVM5 158.1 Da LogP -2.18 TPSA 113.3 ✓ Ro5 ✓ Clean [C@H]1(C(=O)NC(=O)N1)NC(=O)N
GUN
2O74
A1L259 151.1 Da LogP -0.77 TPSA 100.5 ✓ Ro5 ✓ Clean c1[nH]c2c(n1)C(=O)NC(=N2)N

PDB and ChEMBL records on this protein are shown in full. ChEMBL records from similar proteins are capped at the top 100 per protein (by pchembl) and ZINC at the top 50 (Tanimoto ≥ 0.5). ADME columns are descriptor-based screening flags, not experimental toxicity results.