Target Pathogen

Overview

Basic information about this protein and its source genome.

Accession: PA1519
Assembly: Pseudomonas aeruginosa PAO1, complete genome
Gene: PA1519
Status: annotated
Amino acids: 449
Structure source: AlphaFold

GO

GO:0005886 The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. GO:0015207 Enables the transfer of adenine, 6-aminopurine, from one side of a membrane to the other. GO:0015205 Enables the transfer of a nucleobase, any nitrogenous base that is a constituent of a nucleoside, nucleotide, or nucleic acidfrom one side of a membrane to the other. GO:0022857 Enables the transfer of a substance, usually a specific substance or a group of related substances, from one side of a membrane to the other. GO:0055085 The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other. GO:0016020 A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it.

Target profile

Computed evidence for target prioritization.

Human off-target: No hit
Gut microbiome off-target: hit
Essential (DEG): Y
Localization: CytoplasmicMembrane

Selected Druggability evidence

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.901

Structure –

Pocket –

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

6 GO

Gene Ontology (GO)

6

GO:0005886 The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
GO:0015207 Enables the transfer of adenine, 6-aminopurine, from one side of a membrane to the other.
GO:0015205 Enables the transfer of a nucleobase, any nitrogenous base that is a constituent of a nucleoside, nucleotide, or nucleic acidfrom one side of a membrane to the other.
GO:0022857 Enables the transfer of a substance, usually a specific substance or a group of related substances, from one side of a membrane to the other.
GO:0055085 The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other.
GO:0016020 A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it.

Sequence Features

Domain/signature hits from InterPro and related databases.

40 records

Show feature table

Start	End	DB	Term	Name
247	270	Phobius	TRANSMEMBRANE	Region of a membrane-bound protein predicted to be embedded in the membrane.
115	136	Phobius	TRANSMEMBRANE	Region of a membrane-bound protein predicted to be embedded in the membrane.
1	38	Phobius	NON_CYTOPLASMIC_DOMAIN	Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.
420	430	Phobius	NON_CYTOPLASMIC_DOMAIN	Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.
363	383	Phobius	TRANSMEMBRANE	Region of a membrane-bound protein predicted to be embedded in the membrane.
38	411	Pfam	PF00860	Permease family
38	411	InterPro	IPR006043	Nucleobase cation symporter 2 family
332	354	TMHMM	TMhelix	Region of a membrane-bound protein predicted to be embedded in the membrane.
153	175	TMHMM	TMhelix	Region of a membrane-bound protein predicted to be embedded in the membrane.
178	188	Phobius	NON_CYTOPLASMIC_DOMAIN	Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.
114	136	TMHMM	TMhelix	Region of a membrane-bound protein predicted to be embedded in the membrane.
271	337	Phobius	CYTOPLASMIC_DOMAIN	Region of a membrane-bound protein predicted to be outside the membrane, in the cytoplasm.
208	213	Phobius	CYTOPLASMIC_DOMAIN	Region of a membrane-bound protein predicted to be outside the membrane, in the cytoplasm.
189	207	Phobius	TRANSMEMBRANE	Region of a membrane-bound protein predicted to be embedded in the membrane.
185	204	TMHMM	TMhelix	Region of a membrane-bound protein predicted to be embedded in the membrane.
431	448	TMHMM	TMhelix	Region of a membrane-bound protein predicted to be embedded in the membrane.
359	381	TMHMM	TMhelix	Region of a membrane-bound protein predicted to be embedded in the membrane.
90	114	Phobius	NON_CYTOPLASMIC_DOMAIN	Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.
33	55	TMHMM	TMhelix	Region of a membrane-bound protein predicted to be embedded in the membrane.
338	357	Phobius	TRANSMEMBRANE	Region of a membrane-bound protein predicted to be embedded in the membrane.
384	394	Phobius	CYTOPLASMIC_DOMAIN	Region of a membrane-bound protein predicted to be outside the membrane, in the cytoplasm.
236	246	Phobius	NON_CYTOPLASMIC_DOMAIN	Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.
214	235	Phobius	TRANSMEMBRANE	Region of a membrane-bound protein predicted to be embedded in the membrane.
394	416	TMHMM	TMhelix	Region of a membrane-bound protein predicted to be embedded in the membrane.
57	67	Phobius	CYTOPLASMIC_DOMAIN	Region of a membrane-bound protein predicted to be outside the membrane, in the cytoplasm.
358	362	Phobius	NON_CYTOPLASMIC_DOMAIN	Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.
248	270	TMHMM	TMhelix	Region of a membrane-bound protein predicted to be embedded in the membrane.
67	89	TMHMM	TMhelix	Region of a membrane-bound protein predicted to be embedded in the membrane.
14	449	PIRSF	PIRSF005353	PbuG
14	449	InterPro	IPR026033	Azaguanine-like transporters, bacteria and archaea type
19	442	PANTHER	PTHR43337	XANTHINE/URACIL PERMEASE C887.17-RELATED
19	442	InterPro	IPR045018	Azaguanine-like transporters
39	56	Phobius	TRANSMEMBRANE	Region of a membrane-bound protein predicted to be embedded in the membrane.
395	419	Phobius	TRANSMEMBRANE	Region of a membrane-bound protein predicted to be embedded in the membrane.
68	89	Phobius	TRANSMEMBRANE	Region of a membrane-bound protein predicted to be embedded in the membrane.
449	449	Phobius	CYTOPLASMIC_DOMAIN	Region of a membrane-bound protein predicted to be outside the membrane, in the cytoplasm.
137	156	Phobius	CYTOPLASMIC_DOMAIN	Region of a membrane-bound protein predicted to be outside the membrane, in the cytoplasm.
431	448	Phobius	TRANSMEMBRANE	Region of a membrane-bound protein predicted to be embedded in the membrane.
157	177	Phobius	TRANSMEMBRANE	Region of a membrane-bound protein predicted to be embedded in the membrane.
211	233	TMHMM	TMhelix	Region of a membrane-bound protein predicted to be embedded in the membrane.

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

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Structural evidence

0 + 1

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry	Method	Resolution	Chain	Coverage	Links	Status
AlphaFold PA1519	AlphaFold	—	—	full sequence	—	Viewing

Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET	Sticks	Spheres	Surfaces	Druggability	Labels	Zoom	Positions
3				0.856
1				0.834
2				0.293

Ligand evidence

Ligands grouped by evidence source. PDB ligands keep the source crystal visible, and loaded crystals can be opened directly in the structure viewer.

10 records

Highest-confidence structural evidence: ligands co-crystallized with this exact protein. If the source PDB is loaded in TPW, use Open crystal to inspect it in the structure viewer.

No PDB structure with a co-crystallized ligand found for this exact protein.

Structural evidence inferred from similar proteins. The source crystal indicates where the ligand was observed; the UniProt column identifies the homologous protein carrying that ligand.

No PDB ligands found through similar proteins.

Experimental bioactivity from ChEMBL measured directly on this protein. Score = pchembl (−log Ki/IC₅₀; higher = more potent).

No ChEMBL bioactivity data found for this exact protein.

Bioactivity inferred from similar proteins in ChEMBL. Score = pchembl (−log Ki/IC₅₀; higher = more potent).

Ligand	UniProt (homolog)	pchembl	MW · LogP · TPSA	Lipinski	PAINS	SMILES
CHEMBL4166601	G5EB00	—	301.4 Da LogP 3.63 TPSA 66.5	✓ Ro5	✓ Clean	`c1ccc(CNc2nccc3[nH]c(-c4ccncc4)nc23)cc1`
CHEMBL4170020	G5EB00	—	316.4 Da LogP 3.94 TPSA 73.8	✓ Ro5	✓ Clean	`Oc1ccccc1-c1nc2c(NCc3ccccc3)nccc2[nH]1`
CHEMBL4176165	G5EB00	—	338.4 Da LogP 2.28 TPSA 91.2	✓ Ro5	✓ Clean	`CN1CCN(c2nccc3[nH]c(-c4ccc([N+](=O)[O-])cc4)nc2…`
CHEMBL4177224	G5EB00	—	360.4 Da LogP 4.25 TPSA 72.1	✓ Ro5	✓ Clean	`COc1ccc(OC)c(-c2nc3c(NCc4ccccc4)nccc3[nH]2)c1`

Proposed virtual-screening candidates from ZINC. Score = Tanimoto similarity to a known binder (0–1; higher = more similar).

Ligand	Tanimoto	MW · LogP · TPSA	Lipinski	PAINS	SMILES
ZINC1109800	0.534	364.4 Da LogP 3.80 TPSA 84.3	✓ Ro5	✓ Clean	`Cc1ccc(-c2nc(N3CCOCC3)c(-c3ccc([N+](=O)[O-])cc3…`
ZINC265172417	0.519	236.3 Da LogP 1.05 TPSA 62.5	✓ Ro5	✓ Clean	`Cc1ccnc(N2CCN(C)CC2)c1[N+](=O)[O-]`
ZINC41004999	0.518	254.3 Da LogP 3.25 TPSA 47.1	✓ Ro5	✓ Clean	`COc1ccc(OC)c(-c2nc3ccccc3[nH]2)c1`
ZINC310240976	0.509	237.3 Da LogP 0.32 TPSA 88.5	✓ Ro5	✓ Clean	`CN1CCN(c2nccc(N)c2[N+](=O)[O-])CC1`
ZINC36359819	0.500	388.4 Da LogP 3.79 TPSA 94.1	✓ Ro5	✓ Clean	`COc1ccc(Nc2nc(NCc3ccccc3)c3nccnc3n2)c(OC)c1`
ZINC509842	0.500	312.4 Da LogP 4.30 TPSA 50.7	✓ Ro5	✓ Clean	`c1ccc(CNc2nc(-c3ccncc3)nc3ccccc23)cc1`

PDB and ChEMBL records on this protein are shown in full. ChEMBL records from similar proteins are capped at the top 100 per protein (by pchembl) and ZINC at the top 50 (Tanimoto ≥ 0.5). ADME columns are descriptor-based screening flags, not experimental toxicity results.

PA1519