Protein profile

PA1526

transcriptional regulator

Genome: NC_002516.2

Gene: PA1526 Structure source: Experimental + AlphaFold UniProt Q9I3I7
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Amino acids 219
Annotations 3
Features 19
PDB binders 0
Druggability 0.942

Overview

Basic information about this protein and its source genome.

Accession
PA1526
Assembly
Pseudomonas aeruginosa PAO1, complete genome
Gene
PA1526
Status
annotated
Amino acids
219
Structure source
Experimental + AlphaFold
GO
GO:0000987 Binding to a specific upstream regulatory DNA sequence (transcription factor recognition sequence or binding site, located in cis relative to the transcription start site (i.e., on the same strand of DNA) of a gene transcribed by some RNA polymerase. Cis-regulatory sites are often referred to as a sequence motifs, enhancers, or silencers. GO:0003700 A transcription regulator activity that modulates transcription of gene sets via selective and non-covalent binding to a specific double-stranded genomic DNA sequence (sometimes referred to as a motif) within a cis-regulatory region. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units, and include bacterial operons. GO:0006355 Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription.

Target profile

Computed evidence for target prioritization.

Human off-target
No hit
Gut microbiome off-target
hit
Essential (DEG)
N
Localization
Cytoplasmic

Selected Druggability evidence

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.942
Structure –
Pocket –

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

3 GO

Gene Ontology (GO)

3
  • GO:0000987 Binding to a specific upstream regulatory DNA sequence (transcription factor recognition sequence or binding site, located in cis relative to the transcription start site (i.e., on the same strand of DNA) of a gene transcribed by some RNA polymerase. Cis-regulatory sites are often referred to as a sequence motifs, enhancers, or silencers.
  • GO:0003700 A transcription regulator activity that modulates transcription of gene sets via selective and non-covalent binding to a specific double-stranded genomic DNA sequence (sometimes referred to as a motif) within a cis-regulatory region. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units, and include bacterial operons.
  • GO:0006355 Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription.

Sequence Features

Domain/signature hits from InterPro and related databases.

19 records
Show feature table
Start End DB Term Name
5 75 SUPERFAMILY SSF46785 Winged helix DNA-binding domain
5 75 InterPro IPR036390 Winged helix DNA-binding domain superfamily
8 72 CDD cd07377 WHTH_GntR
8 72 InterPro IPR000524 Transcription regulator HTH, GntR
5 207 PANTHER PTHR43537 TRANSCRIPTIONAL REGULATOR, GNTR FAMILY
3 72 Gene3D G3DSA:1.10.10.10 -
3 72 InterPro IPR036388 Winged helix-like DNA-binding domain superfamily
7 74 ProSiteProfiles PS50949 GntR-type HTH domain profile.
7 74 InterPro IPR000524 Transcription regulator HTH, GntR
9 71 Pfam PF00392 Bacterial regulatory proteins, gntR family
9 71 InterPro IPR000524 Transcription regulator HTH, GntR
88 203 Pfam PF07729 FCD domain
88 203 InterPro IPR011711 GntR, C-terminal
74 214 Gene3D G3DSA:1.20.120.530 -
74 214 InterPro IPR008920 Transcription regulator FadR/GntR, C-terminal
78 215 SUPERFAMILY SSF48008 GntR ligand-binding domain-like
78 215 InterPro IPR008920 Transcription regulator FadR/GntR, C-terminal
13 71 SMART SM00345 gntr3
13 71 InterPro IPR000524 Transcription regulator HTH, GntR

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

3D visualization script Full viewer

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Structural evidence

1 + 1

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry Method Resolution Chain Coverage Links Status
PDB 9ISW
X-ray 1.86 Å A
100.0% 1-219
PDBe RCSB PDBj File
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AlphaFold PA1526
AlphaFold — — full sequence — Loaded
Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET Sticks Spheres Surfaces Druggability Labels Zoom Positions
1 0.942

Pockets (P2RANK)

Showing top-ranked P2Rank candidates by probability. Probability is color-coded per P2Rank calibration: high (≥ 0.5), medium (0.2 – 0.49), low (< 0.2).

P2RANK Sticks Spheres Surfaces Score Probability Labels Zoom Positions
1 40.69 0.964
2 5.1 0.233
3 5.0 0.227
4 2.07 0.046
5 1.31 0.014