Protein profile

PA1527

hypothetical protein

Genome: NC_002516.2

Gene: smc PA1527 Structure source: AlphaFold UniProt Q9I3I6
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Amino acids 1162
Annotations 11
Features 34
PDB binders 1
Druggability 0.444

Overview

Basic information about this protein and its source genome.

Accession
PA1527
Assembly
Pseudomonas aeruginosa PAO1, complete genome
Gene
smc PA1527
Status
annotated
Amino acids
1162
Structure source
AlphaFold
GO
GO:0005694 A structure composed of a very long molecule of DNA and associated proteins (e.g. histones) that carries hereditary information. GO:0005737 The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. GO:0005524 Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. GO:0016887 Catalysis of the reaction: ATP + H2O = ADP + H+ phosphate. ATP hydrolysis is used in some reactions as an energy source, for example to catalyze a reaction or drive transport against a concentration gradient. GO:0003677 Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid). GO:0030261 The progressive compaction of dispersed interphase chromatin into threadlike chromosomes prior to mitotic or meiotic nuclear division, or during apoptosis, in eukaryotic cells.

Target profile

Computed evidence for target prioritization.

Human off-target
hit
Human identity (%)
32.683
Human E-value
3.33e-21
Gut microbiome off-target
hit
Essential (DEG)
Y
Localization
Cytoplasmic

Selected Druggability evidence

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.444
Structure –
Pocket –

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

11 GO

Gene Ontology (GO)

11
  • GO:0005694 A structure composed of a very long molecule of DNA and associated proteins (e.g. histones) that carries hereditary information.
  • GO:0005737 The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
  • GO:0005524 Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
  • GO:0016887 Catalysis of the reaction: ATP + H2O = ADP + H+ phosphate. ATP hydrolysis is used in some reactions as an energy source, for example to catalyze a reaction or drive transport against a concentration gradient.
  • GO:0003677 Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid).
  • GO:0030261 The progressive compaction of dispersed interphase chromatin into threadlike chromosomes prior to mitotic or meiotic nuclear division, or during apoptosis, in eukaryotic cells.
  • GO:0007059 The process in which genetic material, in the form of chromosomes, is organized into specific structures and then physically separated and apportioned to two or more sets. In eukaryotes, chromosome segregation begins with the condensation of chromosomes, includes chromosome separation, and ends when chromosomes have completed movement to the spindle poles.
  • GO:0006260 The cellular metabolic process in which a cell duplicates one or more molecules of DNA. DNA replication begins when specific sequences, known as origins of replication, are recognized and bound by the origin recognition complex, and ends when the original DNA molecule has been completely duplicated and the copies topologically separated. The unit of replication usually corresponds to the genome of the cell, an organelle, or a virus. The template for replication can either be an existing DNA molecule or RNA.
  • GO:0007062 The cell cycle process in which the sister chromatids of a replicated chromosome become tethered to each other.
  • GO:0051276 A process that is carried out at the cellular level that results in the assembly, arrangement of constituent parts, or disassembly of chromosomes, structures composed of a very long molecule of DNA and associated proteins that carries hereditary information. This term covers covalent modifications at the molecular level as well as spatial relationships among the major components of a chromosome.
  • GO:0005515 Binding to a protein.

Sequence Features

Domain/signature hits from InterPro and related databases.

34 records
Show feature table
Start End DB Term Name
803 837 Coils Coil Coil
2 1153 NCBIfam TIGR02168 chromosome segregation protein SMC
2 1153 InterPro IPR011890 Structural maintenance of chromosomes protein, prokaryotic
1 251 Gene3D G3DSA:3.40.50.300 -
1 251 InterPro IPR027417 P-loop containing nucleoside triphosphate hydrolase
305 341 MobiDBLite mobidb-lite consensus disorder prediction
980 1007 Coils Coil Coil
1 1138 SUPERFAMILY SSF52540 P-loop containing nucleoside triphosphate hydrolases
1 1138 InterPro IPR027417 P-loop containing nucleoside triphosphate hydrolase
398 432 Coils Coil Coil
170 218 Coils Coil Coil
1 1162 PIRSF PIRSF005719 SMC
1 1162 InterPro IPR024704 Structural maintenance of chromosomes protein
315 337 MobiDBLite mobidb-lite consensus disorder prediction
3 156 CDD cd03278 ABC_SMC_barmotin
307 334 Coils Coil Coil
1 554 PANTHER PTHR43977 STRUCTURAL MAINTENANCE OF CHROMOSOMES PROTEIN 3
438 500 Coils Coil Coil
768 795 Coils Coil Coil
469 662 SUPERFAMILY SSF75553 Smc hinge domain
469 662 InterPro IPR036277 SMCs flexible hinge superfamily
845 907 Coils Coil Coil
363 390 Coils Coil Coil
272 292 Coils Coil Coil
520 615 SMART SM00968 SMC_hinge_2
520 615 InterPro IPR010935 SMCs flexible hinge
975 1160 Gene3D G3DSA:3.40.50.300 -
975 1160 InterPro IPR027417 P-loop containing nucleoside triphosphate hydrolase
3 1146 Pfam PF02463 RecF/RecN/SMC N terminal domain
3 1146 InterPro IPR003395 RecF/RecN/SMC, N-terminal
1 1155 Hamap MF_01894 Chromosome partition protein Smc [smc].
1 1155 InterPro IPR011890 Structural maintenance of chromosomes protein, prokaryotic
649 753 Coils Coil Coil
1054 1147 CDD cd03278 ABC_SMC_barmotin

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

3D visualization script Full viewer

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Structural evidence

0 + 1

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry Method Resolution Chain Coverage Links Status
AlphaFold PA1527
AlphaFold — — full sequence — Viewing
Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET Sticks Spheres Surfaces Druggability Labels Zoom Positions
1 0.412

Ligand evidence

Ligands grouped by evidence source. PDB ligands keep the source crystal visible, and loaded crystals can be opened directly in the structure viewer.

51 records

Structural evidence inferred from similar proteins. The source crystal indicates where the ligand was observed; the UniProt column identifies the homologous protein carrying that ligand.

Show only:
Ligand Source crystal UniProt (homolog) MW · LogP · TPSA Lipinski PAINS SMILES
AGS
6QPW
G0SGH3 523.2 Da LogP -1.51 TPSA 262.1 3 viol. ✓ Clean c1nc(c2c(n1)n(cn2)[C@H]3[C@@H]([C@@H]([C@H](O3)…

PDB and ChEMBL records on this protein are shown in full. ChEMBL records from similar proteins are capped at the top 100 per protein (by pchembl) and ZINC at the top 50 (Tanimoto ≥ 0.5). ADME columns are descriptor-based screening flags, not experimental toxicity results.