Protein profile

PA1534

recombination protein RecR

Genome: NC_002516.2

Gene: PA1534 recR Structure source: Experimental + AlphaFold UniProt Q9I3H9
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Amino acids 198
Annotations 7
Features 23
PDB binders 0
Druggability 0.835

Overview

Basic information about this protein and its source genome.

Accession
PA1534
Assembly
Pseudomonas aeruginosa PAO1, complete genome
Gene
PA1534 recR
Status
annotated
Amino acids
198
Structure source
Experimental + AlphaFold
GO
GO:0003677 Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid). GO:0008270 Binding to a zinc ion (Zn). GO:0006302 The repair of double-strand breaks in DNA via homologous and nonhomologous mechanisms to reform a continuous DNA helix. GO:0000725 A DNA repair process that involves the exchange, reciprocal or nonreciprocal, of genetic material between the broken DNA molecule and a homologous DNA region. GO:0006310 Any process in which a new genotype is formed by reassortment of genes resulting in gene combinations different from those that were present in the parents. In eukaryotes genetic recombination can occur by chromosome assortment, intrachromosomal recombination, or nonreciprocal interchromosomal recombination. Interchromosomal recombination occurs by crossing over. In bacteria it may occur by genetic transformation, conjugation, transduction, or F-duction. GO:0046872 Binding to a metal ion.

Target profile

Computed evidence for target prioritization.

Human off-target
No hit
Gut microbiome off-target
hit
Essential (DEG)
Y
Localization
Cytoplasmic

Selected Druggability evidence

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.835
Structure –
Pocket –

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

7 GO

Gene Ontology (GO)

7
  • GO:0003677 Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid).
  • GO:0008270 Binding to a zinc ion (Zn).
  • GO:0006302 The repair of double-strand breaks in DNA via homologous and nonhomologous mechanisms to reform a continuous DNA helix.
  • GO:0000725 A DNA repair process that involves the exchange, reciprocal or nonreciprocal, of genetic material between the broken DNA molecule and a homologous DNA region.
  • GO:0006310 Any process in which a new genotype is formed by reassortment of genes resulting in gene combinations different from those that were present in the parents. In eukaryotes genetic recombination can occur by chromosome assortment, intrachromosomal recombination, or nonreciprocal interchromosomal recombination. Interchromosomal recombination occurs by crossing over. In bacteria it may occur by genetic transformation, conjugation, transduction, or F-duction.
  • GO:0046872 Binding to a metal ion.
  • GO:0006281 The process of restoring DNA after damage. Genomes are subject to damage by chemical and physical agents in the environment (e.g. UV and ionizing radiations, chemical mutagens, fungal and bacterial toxins, etc.) and by free radicals or alkylating agents endogenously generated in metabolism. DNA is also damaged because of errors during its replication. A variety of different DNA repair pathways have been reported that include direct reversal, base excision repair, nucleotide excision repair, photoreactivation, bypass, double-strand break repair pathway, and mismatch repair pathway.

Sequence Features

Domain/signature hits from InterPro and related databases.

23 records
Show feature table
Start End DB Term Name
81 170 Pfam PF13662 Toprim domain
81 170 InterPro IPR006171 TOPRIM domain
80 164 SMART SM00493 toprim5
80 164 InterPro IPR006171 TOPRIM domain
57 78 ProSitePatterns PS01300 RecR protein signature.
57 78 InterPro IPR015967 Recombination protein RecR, conserved site
77 169 Gene3D G3DSA:3.40.1360.10 -
1 197 Hamap MF_00017 Recombination protein RecR [recR].
1 197 InterPro IPR000093 DNA recombination protein RecR
3 197 SUPERFAMILY SSF111304 Recombination protein RecR
3 197 InterPro IPR023627 Recombination protein RecR
1 52 Gene3D G3DSA:1.10.8.420 RecR Domain 1
2 196 PANTHER PTHR30446 RECOMBINATION PROTEIN RECR
2 196 InterPro IPR000093 DNA recombination protein RecR
80 174 ProSiteProfiles PS50880 Toprim domain profile.
80 174 InterPro IPR006171 TOPRIM domain
41 78 Pfam PF02132 RecR protein
41 78 InterPro IPR023628 Recombination protein RecR, C4-type zinc finger
170 198 Gene3D G3DSA:6.10.250.240 -
2 195 NCBIfam TIGR00615 recombination mediator RecR
2 195 InterPro IPR000093 DNA recombination protein RecR
80 190 CDD cd01025 TOPRIM_recR
80 190 InterPro IPR034137 RecR, TOPRIM domain

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

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Structural evidence

1 + 1

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry Method Resolution Chain Coverage Links Status
PDB 5Z2V
X-ray 2.20 Å A,B
100.0% 1-198
PDBe RCSB PDBj File
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AlphaFold PA1534
AlphaFold — — full sequence — Loaded
Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET Sticks Spheres Surfaces Druggability Labels Zoom Positions
2 0.835

Pockets (P2RANK)

Showing top-ranked P2Rank candidates by probability. Probability is color-coded per P2Rank calibration: high (≥ 0.5), medium (0.2 – 0.49), low (< 0.2).

P2RANK Sticks Spheres Surfaces Score Probability Labels Zoom Positions
1 2.57 0.073