Protein profile

PA1539

hypothetical protein

Genome: NC_002516.2

Gene: PA1539 Structure source: AlphaFold UniProt Q9I3H4

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Amino acids 282

Annotations 1

Features 12

PDB binders 0

Druggability 0.845

Overview

Basic information about this protein and its source genome.

Accession: PA1539
Assembly: Pseudomonas aeruginosa PAO1, complete genome
Gene: PA1539
Status: annotated
Amino acids: 282
Structure source: AlphaFold

GO:0003677 Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid).

Target profile

Computed evidence for target prioritization.

Human off-target: No hit
Gut microbiome off-target: hit
Essential (DEG): N
Localization: Cytoplasmic

Selected Druggability evidence

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.845

Structure –

Pocket –

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

1 GO

Gene Ontology (GO)

GO:0003677 Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid).

Sequence Features

Domain/signature hits from InterPro and related databases.

12 records

Show feature table

Start	End	DB	Term	Name
239	253	MobiDBLite	mobidb-lite	consensus disorder prediction
58	236	Gene3D	G3DSA:1.10.357.10	Tetracycline Repressor, domain 2
4	229	PANTHER	PTHR47752	HTH-TYPE TRANSCRIPTIONAL REPRESSOR FABR
14	75	ProSiteProfiles	PS50977	TetR-type HTH domain profile.
14	75	InterPro	IPR001647	DNA-binding HTH domain, TetR-type
237	282	MobiDBLite	mobidb-lite	consensus disorder prediction
20	63	Pfam	PF00440	Bacterial regulatory proteins, tetR family
20	63	InterPro	IPR001647	DNA-binding HTH domain, TetR-type
12	57	Gene3D	G3DSA:1.10.10.60	-
265	282	MobiDBLite	mobidb-lite	consensus disorder prediction
17	79	SUPERFAMILY	SSF46689	Homeodomain-like
17	79	InterPro	IPR009057	Homeobox-like domain superfamily

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

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Structural evidence

0 + 1

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry	Method	Resolution	Chain	Coverage	Links	Status
AlphaFold PA1539	AlphaFold	—	—	full sequence	—	Viewing

Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET	Sticks	Spheres	Surfaces	Druggability	Labels	Zoom	Positions
1				0.845