Protein profile

PA1544

transcriptional regulator Anr

Genome: NC_002516.2

Gene: anr PA1544 Structure source: AlphaFold UniProt P23926
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Amino acids 244
Annotations 8
Features 33
PDB binders 6
Druggability 0.493

Overview

Basic information about this protein and its source genome.

Accession
PA1544
Assembly
Pseudomonas aeruginosa PAO1, complete genome
Gene
anr PA1544
Status
annotated
Amino acids
244
Structure source
AlphaFold
GO
GO:0005829 The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. GO:0003677 Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid). GO:0003700 A transcription regulator activity that modulates transcription of gene sets via selective and non-covalent binding to a specific double-stranded genomic DNA sequence (sometimes referred to as a motif) within a cis-regulatory region. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units, and include bacterial operons. GO:0036294 Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus reflecting a decline in the level of oxygen. GO:0046202 The chemical reactions and pathways resulting in the formation of cyanide, NC-, the anion of hydrocyanic acid. Cyanide is a potent inhibitor of respiration. GO:1900081 Any process that modulates the frequency, rate or extent of arginine catabolic process.

Target profile

Computed evidence for target prioritization.

Human off-target
No hit
Gut microbiome off-target
hit
Essential (DEG)
N
Localization
Cytoplasmic

Selected Druggability evidence

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.493
Structure –
Pocket –

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

8 GO

Gene Ontology (GO)

8
  • GO:0005829 The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
  • GO:0003677 Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid).
  • GO:0003700 A transcription regulator activity that modulates transcription of gene sets via selective and non-covalent binding to a specific double-stranded genomic DNA sequence (sometimes referred to as a motif) within a cis-regulatory region. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units, and include bacterial operons.
  • GO:0036294 Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus reflecting a decline in the level of oxygen.
  • GO:0046202 The chemical reactions and pathways resulting in the formation of cyanide, NC-, the anion of hydrocyanic acid. Cyanide is a potent inhibitor of respiration.
  • GO:1900081 Any process that modulates the frequency, rate or extent of arginine catabolic process.
  • GO:0006355 Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription.
  • GO:0036293 Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus reflecting a decline in the level of oxygen.

Sequence Features

Domain/signature hits from InterPro and related databases.

33 records
Show feature table
Start End DB Term Name
161 239 SUPERFAMILY SSF46785 Winged helix DNA-binding domain
161 239 InterPro IPR036390 Winged helix DNA-binding domain superfamily
124 144 Coils Coil Coil
182 230 SMART SM00419 crpmeuga4
182 230 InterPro IPR012318 Crp-type HTH domain
14 159 FunFam G3DSA:2.60.120.10:FF:000004 Fumarate/nitrate reduction transcriptional regulator Fnr
160 241 Gene3D G3DSA:1.10.10.10 -
160 241 InterPro IPR036388 Winged helix-like DNA-binding domain superfamily
25 238 PANTHER PTHR24567 CRP FAMILY TRANSCRIPTIONAL REGULATORY PROTEIN
188 219 Pfam PF00325 Bacterial regulatory proteins, crp family
188 219 InterPro IPR012318 Crp-type HTH domain
34 123 ProSiteProfiles PS50042 cAMP/cGMP binding motif profile.
34 123 InterPro IPR000595 Cyclic nucleotide-binding domain
159 232 ProSiteProfiles PS51063 Crp-type HTH domain profile.
159 232 InterPro IPR012318 Crp-type HTH domain
45 129 Pfam PF00027 Cyclic nucleotide-binding domain
45 129 InterPro IPR000595 Cyclic nucleotide-binding domain
25 139 CDD cd00038 CAP_ED
25 139 InterPro IPR000595 Cyclic nucleotide-binding domain
161 230 CDD cd00092 HTH_CRP
25 146 SMART SM00100 cnmp_10
25 146 InterPro IPR000595 Cyclic nucleotide-binding domain
160 240 FunFam G3DSA:1.10.10.10:FF:000028 Fumarate/nitrate reduction transcriptional regulator Fnr
190 213 ProSitePatterns PS00042 Crp-type HTH domain signature.
190 213 InterPro IPR018335 Transcription regulator HTH, Crp-type, conserved site
204 219 PRINTS PR00034 CRP bacterial regulatory protein HTH signature
204 219 InterPro IPR012318 Crp-type HTH domain
188 204 PRINTS PR00034 CRP bacterial regulatory protein HTH signature
188 204 InterPro IPR012318 Crp-type HTH domain
18 157 SUPERFAMILY SSF51206 cAMP-binding domain-like
18 157 InterPro IPR018490 Cyclic nucleotide-binding domain superfamily
14 159 Gene3D G3DSA:2.60.120.10 Jelly Rolls
14 159 InterPro IPR014710 RmlC-like jelly roll fold

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

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Structural evidence

0 + 1

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry Method Resolution Chain Coverage Links Status
AlphaFold PA1544
AlphaFold — — full sequence — Viewing
Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET Sticks Spheres Surfaces Druggability Labels Zoom Positions
1 0.308

Ligand evidence

Ligands grouped by evidence source. PDB ligands keep the source crystal visible, and loaded crystals can be opened directly in the structure viewer.

56 records

Structural evidence inferred from similar proteins. The source crystal indicates where the ligand was observed; the UniProt column identifies the homologous protein carrying that ligand.

Show only:
Ligand Source crystal UniProt (homolog) MW · LogP · TPSA Lipinski PAINS SMILES
2FT
3LA3
P0A4U6 168.1 Da LogP 0.57 TPSA 74.6 ✓ Ro5 ✓ Clean C(CC(C(=O)O)(F)F)C(=O)O
AKG
3LA2
P0A4U6 146.1 Da LogP -0.50 TPSA 91.7 ✓ Ro5 ✓ Clean C(CC(=O)O)C(=O)C(=O)O
BTB
2XGX
P29283 209.2 Da LogP -3.01 TPSA 104.4 ✓ Ro5 ✓ Clean C(CO)N(CCO)C(CO)(CO)CO
FES
5CVR
Q70ET4 175.8 Da LogP 1.29 TPSA 0.0 ✓ Ro5 ✓ Clean S1[Fe]S[Fe]1
PCG
4N9I
C3SQJ7 345.2 Da LogP -1.52 TPSA 174.8 ✓ Ro5 ✓ Clean c1nc2c(n1[C@H]3[C@@H]([C@H]4C(O3)CO[P@](=O)(O4)…
SP1
4R8H
P0ACJ8 345.3 Da LogP -0.70 TPSA 137.8 ✓ Ro5 ✓ Clean c1nc(c2c(n1)n(cn2)[C@H]3[C@@H]([C@H]4[C@H](O3)C…

PDB and ChEMBL records on this protein are shown in full. ChEMBL records from similar proteins are capped at the top 100 per protein (by pchembl) and ZINC at the top 50 (Tanimoto ≥ 0.5). ADME columns are descriptor-based screening flags, not experimental toxicity results.