Target Pathogen

Overview

Basic information about this protein and its source genome.

Accession: PA1551
Assembly: Pseudomonas aeruginosa PAO1, complete genome
Gene: PA1551
Status: annotated
Amino acids: 471
Structure source: AlphaFold

GO

GO:0005737 The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. GO:0016020 A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. GO:0051539 Binding to a 4 iron, 4 sulfur (4Fe-4S) cluster; this cluster consists of four iron atoms, with the inorganic sulfur atoms found between the irons and acting as bridging ligands. GO:0046872 Binding to a metal ion. GO:0051536 Binding to an iron-sulfur cluster, a combination of iron and sulfur atoms.

Target profile

Computed evidence for target prioritization.

Human off-target: No hit
Gut microbiome off-target: hit
Essential (DEG): Y
Localization: CytoplasmicMembrane

Selected Druggability evidence

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.835

Structure –

Pocket –

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

5 GO

Gene Ontology (GO)

5

GO:0005737 The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
GO:0016020 A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it.
GO:0051539 Binding to a 4 iron, 4 sulfur (4Fe-4S) cluster; this cluster consists of four iron atoms, with the inorganic sulfur atoms found between the irons and acting as bridging ligands.
GO:0046872 Binding to a metal ion.
GO:0051536 Binding to an iron-sulfur cluster, a combination of iron and sulfur atoms.

Sequence Features

Domain/signature hits from InterPro and related databases.

33 records

Show feature table

Start	End	DB	Term	Name
164	183	Phobius	TRANSMEMBRANE	Region of a membrane-bound protein predicted to be embedded in the membrane.
352	468	Pfam	PF11614	IG-like fold at C-terminal of FixG, putative oxidoreductase
352	468	InterPro	IPR032879	FixG, C-terminal immunoglobulin-like domain
353	467	Gene3D	G3DSA:2.60.40.10	Immunoglobulins
353	467	InterPro	IPR013783	Immunoglobulin-like fold
40	327	PANTHER	PTHR30176	FERREDOXIN-TYPE PROTEIN NAPH
47	69	TMHMM	TMhelix	Region of a membrane-bound protein predicted to be embedded in the membrane.
270	281	ProSitePatterns	PS00198	4Fe-4S ferredoxin-type iron-sulfur binding region signature.
270	281	InterPro	IPR017900	4Fe-4S ferredoxin, iron-sulphur binding, conserved site
89	111	TMHMM	TMhelix	Region of a membrane-bound protein predicted to be embedded in the membrane.
260	289	ProSiteProfiles	PS51379	4Fe-4S ferredoxin-type iron-sulfur binding domain profile.
260	289	InterPro	IPR017896	4Fe-4S ferredoxin-type, iron-sulphur binding domain
91	111	Phobius	TRANSMEMBRANE	Region of a membrane-bound protein predicted to be embedded in the membrane.
218	337	Phobius	CYTOPLASMIC_DOMAIN	Region of a membrane-bound protein predicted to be outside the membrane, in the cytoplasm.
184	197	Phobius	NON_CYTOPLASMIC_DOMAIN	Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.
198	217	TMHMM	TMhelix	Region of a membrane-bound protein predicted to be embedded in the membrane.
103	352	SUPERFAMILY	SSF54862	4Fe-4S ferredoxins
112	163	Phobius	CYTOPLASMIC_DOMAIN	Region of a membrane-bound protein predicted to be outside the membrane, in the cytoplasm.
217	322	Pfam	PF13746	4Fe-4S dicluster domain
217	322	InterPro	IPR017896	4Fe-4S ferredoxin-type, iron-sulphur binding domain
220	290	FunFam	G3DSA:1.10.1060.10:FF:000015	Cytochrome c oxidase accessory protein CcoG
1	41	Phobius	CYTOPLASMIC_DOMAIN	Region of a membrane-bound protein predicted to be outside the membrane, in the cytoplasm.
164	183	TMHMM	TMhelix	Region of a membrane-bound protein predicted to be embedded in the membrane.
39	468	NCBIfam	TIGR02745	cytochrome c oxidase accessory protein CcoG
39	468	InterPro	IPR014116	Cytochrome c oxidase cbb3 type, accessory protein FixG
338	358	Phobius	TRANSMEMBRANE	Region of a membrane-bound protein predicted to be embedded in the membrane.
359	471	Phobius	NON_CYTOPLASMIC_DOMAIN	Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.
338	357	TMHMM	TMhelix	Region of a membrane-bound protein predicted to be embedded in the membrane.
220	292	Gene3D	G3DSA:1.10.1060.10	-
220	292	InterPro	IPR009051	Alpha-helical ferredoxin
63	90	Phobius	NON_CYTOPLASMIC_DOMAIN	Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.
198	217	Phobius	TRANSMEMBRANE	Region of a membrane-bound protein predicted to be embedded in the membrane.
42	62	Phobius	TRANSMEMBRANE	Region of a membrane-bound protein predicted to be embedded in the membrane.

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

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Structural evidence

0 + 1

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry	Method	Resolution	Chain	Coverage	Links	Status
AlphaFold PA1551	AlphaFold	—	—	full sequence	—	Viewing

Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET	Sticks	Spheres	Surfaces	Druggability	Labels	Zoom	Positions
4				0.835
6				0.629
1				0.245

PA1551