Target Pathogen

Overview

Basic information about this protein and its source genome.

Accession: PA1553
Assembly: Pseudomonas aeruginosa PAO1, complete genome
Gene: ccoO1 PA1553
Status: annotated
Amino acids: 203
Structure source: AlphaFold

GO

GO:0004129 Catalysis of the reaction: 4 Fe(II)-[cytochrome c] + O2 + 8 H+(in) = 4 Fe(III)-[cytochrome c] + 2 H2O + 4 H+(out). GO:0020037 Binding to a heme, a compound composed of iron complexed in a porphyrin (tetrapyrrole) ring. GO:0046872 Binding to a metal ion. GO:0009055 A molecular function representing the directed movement of electrons from one molecular entity to another, typically mediated by electron carriers or acceptors, resulting in the transfer of energy and/or the reduction-oxidation (redox) transformation of chemical species. This activity is fundamental to various biological processes, including cellular respiration and photosynthesis, as well as numerous enzymatic reactions involved in metabolic pathways.

Target profile

Computed evidence for target prioritization.

Human off-target: No hit
Gut microbiome off-target: hit
Essential (DEG): Y
Localization: Cytoplasmic

Selected Druggability evidence

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.77

Structure –

Pocket –

Sequence

Primary amino-acid sequence viewer.

MKNHEILEKNVGLLAIFMVIAVSIGGLTQIVPLFFQDVTNTPVEGMKPRTALELEGRDIYIREGCVGCHSQMVRPFRAETERYGHYSVAGESVWDHPFLWGSKRTGPDLARVGGRYSDDWHRAHLYNPRNVVPESKMPAYPWLVENKLDGKDTATKMEVLRKLGVPYTDEDIAGAREAVKGKTEMDALVAFLQGLGTSIKSKR

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

4 GO

Gene Ontology (GO)

4

GO:0004129 Catalysis of the reaction: 4 Fe(II)-[cytochrome c] + O2 + 8 H+(in) = 4 Fe(III)-[cytochrome c] + 2 H2O + 4 H+(out).
GO:0020037 Binding to a heme, a compound composed of iron complexed in a porphyrin (tetrapyrrole) ring.
GO:0046872 Binding to a metal ion.
GO:0009055 A molecular function representing the directed movement of electrons from one molecular entity to another, typically mediated by electron carriers or acceptors, resulting in the transfer of energy and/or the reduction-oxidation (redox) transformation of chemical species. This activity is fundamental to various biological processes, including cellular respiration and photosynthesis, as well as numerous enzymatic reactions involved in metabolic pathways.

Sequence Features

Domain/signature hits from InterPro and related databases.

16 records

Show feature table

Start	End	DB	Term	Name
16	196	SUPERFAMILY	SSF46626	Cytochrome c
16	196	InterPro	IPR036909	Cytochrome c-like domain superfamily
41	203	Gene3D	G3DSA:1.10.760.10	-
41	203	InterPro	IPR036909	Cytochrome c-like domain superfamily
1	11	Phobius	CYTOPLASMIC_DOMAIN	Region of a membrane-bound protein predicted to be outside the membrane, in the cytoplasm.
4	181	Pfam	PF02433	Cytochrome C oxidase, mono-heme subunit/FixO
4	181	InterPro	IPR003468	Cytochrome c oxidase, monohaem subunit/FixO
51	196	ProSiteProfiles	PS51007	Cytochrome c family profile.
51	196	InterPro	IPR009056	Cytochrome c-like domain
41	203	FunFam	G3DSA:1.10.760.10:FF:000003	Cbb3-type cytochrome c oxidase subunit II
13	35	TMHMM	TMhelix	Region of a membrane-bound protein predicted to be embedded in the membrane.
12	35	Phobius	TRANSMEMBRANE	Region of a membrane-bound protein predicted to be embedded in the membrane.
1	40	Gene3D	G3DSA:6.10.250.2250	-
36	203	Phobius	NON_CYTOPLASMIC_DOMAIN	Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.
4	179	NCBIfam	TIGR00781	cytochrome-c oxidase, cbb3-type subunit II
4	179	InterPro	IPR003468	Cytochrome c oxidase, monohaem subunit/FixO

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

Loading 3D structure...

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Structural evidence

0 + 1

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry	Method	Resolution	Chain	Coverage	Links	Status
AlphaFold PA1553	AlphaFold	—	—	full sequence	—	Viewing

Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET	Sticks	Spheres	Surfaces	Druggability	Labels	Zoom	Positions
1				0.77

PA1553