Target Pathogen

Overview

Basic information about this protein and its source genome.

Accession: PA1561
Assembly: Pseudomonas aeruginosa PAO1, complete genome
Gene: PA1561 tlpC aer
Status: annotated
Amino acids: 521
Structure source: AlphaFold

GO

GO:0005886 The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. GO:0004888 Combining with an extracellular or intracellular signal and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity or state as part of signal transduction. GO:0009454 The directed movement of a motile cell or organism in response to environmental oxygen. GO:0006935 The directed movement of a motile cell or organism, or the directed growth of a cell guided by a specific chemical concentration gradient. Movement may be towards a higher concentration (positive chemotaxis) or towards a lower concentration (negative chemotaxis). GO:0052131 The directed movement of a motile cell or organism towards a higher concentration of environmental oxygen. GO:0007165 The cellular process in which a signal is conveyed to trigger a change in the activity or state of a cell. Signal transduction begins with reception of a signal (e.g. a ligand binding to a receptor or receptor activation by a stimulus such as light), or for signal transduction in the absence of ligand, signal-withdrawal or the activity of a constitutively active receptor. Signal transduction ends with regulation of a downstream cellular process, e.g. regulation of transcription or regulation of a metabolic process. Signal transduction covers signaling from receptors located on the surface of the cell and signaling via molecules located within the cell. For signaling between cells, signal transduction is restricted to events at and within the receiving cell.

Target profile

Computed evidence for target prioritization.

Human off-target: No hit
Gut microbiome off-target: hit
Essential (DEG): Y
Localization: CytoplasmicMembrane

Selected Druggability evidence

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.737

Structure –

Pocket –

Sequence

Primary amino-acid sequence viewer.

MRNNQPITQHERVYPAEQRLITTTNLKGIITYCNEAFIDISGFSREELMSAPHNLIRHPDVPPAVFAHMWTTLKAGRPWMGIVKNRCKNGDHYWVSAYVTPIYDQGAVVGYESVRVKPTAEQIQRAEALYRRLGAGKPAIPRRDRWLPVLLDWLPFILISQIGFLIGIWLNSWWGFILAGLLAVPLGLAGLRWQKRGLKRLMRLAEQTTSDPLIAQMYTDSRGDQARLEMAILSQDARLKTCLTRLQDTAEYLTEQARQADTLAHHSSAGLEQQRAETEQVATAVNEMAATTQEVANNVQLTADATQKANELTSRGRDIAAETRNAIQRLSESVGETGAAVSRLAQDSNEIGGVVDVIKGIADQTNLLALNAAIEAARAGDQGRGFAVVADEVRSLAQRTAASTEQIHHLIAKLQNTANDAVHTMESGLQQAEAGVQRVLEADSALVGISEAVSNITEMTTQIAAAAEEQSAVAEEINRNISTIAALAEQTSDEALRTAKLSEELTTTAQSQYSLVERFNR

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

8 GO

Gene Ontology (GO)

8

GO:0005886 The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
GO:0004888 Combining with an extracellular or intracellular signal and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity or state as part of signal transduction.
GO:0009454 The directed movement of a motile cell or organism in response to environmental oxygen.
GO:0006935 The directed movement of a motile cell or organism, or the directed growth of a cell guided by a specific chemical concentration gradient. Movement may be towards a higher concentration (positive chemotaxis) or towards a lower concentration (negative chemotaxis).
GO:0052131 The directed movement of a motile cell or organism towards a higher concentration of environmental oxygen.
GO:0007165 The cellular process in which a signal is conveyed to trigger a change in the activity or state of a cell. Signal transduction begins with reception of a signal (e.g. a ligand binding to a receptor or receptor activation by a stimulus such as light), or for signal transduction in the absence of ligand, signal-withdrawal or the activity of a constitutively active receptor. Signal transduction ends with regulation of a downstream cellular process, e.g. regulation of transcription or regulation of a metabolic process. Signal transduction covers signaling from receptors located on the surface of the cell and signaling via molecules located within the cell. For signaling between cells, signal transduction is restricted to events at and within the receiving cell.
GO:0016020 A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it.
GO:0005515 Binding to a protein.

Sequence Features

Domain/signature hits from InterPro and related databases.

38 records

Show feature table

Start	End	DB	Term	Name
173	519	PANTHER	PTHR32089	METHYL-ACCEPTING CHEMOTAXIS PROTEIN MCPB
279	308	PRINTS	PR00260	Bacterial chemotaxis sensory transducer signature
279	308	InterPro	IPR004090	Chemotaxis methyl-accepting receptor
357	384	PRINTS	PR00260	Bacterial chemotaxis sensory transducer signature
357	384	InterPro	IPR004090	Chemotaxis methyl-accepting receptor
386	415	PRINTS	PR00260	Bacterial chemotaxis sensory transducer signature
386	415	InterPro	IPR004090	Chemotaxis methyl-accepting receptor
192	521	FunFam	G3DSA:1.10.287.950:FF:000001	Methyl-accepting chemotaxis sensory transducer
194	521	Phobius	CYTOPLASMIC_DOMAIN	Region of a membrane-bound protein predicted to be outside the membrane, in the cytoplasm.
231	521	Gene3D	G3DSA:1.10.287.950	-
259	520	SMART	SM00283	MA_2
259	520	InterPro	IPR004089	Methyl-accepting chemotaxis protein (MCP) signalling domain
168	172	Phobius	NON_CYTOPLASMIC_DOMAIN	Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.
21	111	NCBIfam	TIGR00229	PAS domain S-box protein
21	111	InterPro	IPR000014	PAS domain
286	485	CDD	cd11386	MCP_signal
21	76	ProSiteProfiles	PS50112	PAS repeat profile.
21	76	InterPro	IPR000014	PAS domain
1	145	Phobius	CYTOPLASMIC_DOMAIN	Region of a membrane-bound protein predicted to be outside the membrane, in the cytoplasm.
318	487	Pfam	PF00015	Methyl-accepting chemotaxis protein (MCP) signalling domain
318	487	InterPro	IPR004089	Methyl-accepting chemotaxis protein (MCP) signalling domain
249	485	ProSiteProfiles	PS50111	Bacterial chemotaxis sensory transducers domain profile.
249	485	InterPro	IPR004089	Methyl-accepting chemotaxis protein (MCP) signalling domain
31	113	Pfam	PF08447	PAS fold
31	113	InterPro	IPR013655	PAS fold-3
146	167	Phobius	TRANSMEMBRANE	Region of a membrane-bound protein predicted to be embedded in the membrane.
21	114	SUPERFAMILY	SSF55785	PYP-like sensor domain (PAS domain)
21	114	InterPro	IPR035965	PAS domain superfamily
147	169	TMHMM	TMhelix	Region of a membrane-bound protein predicted to be embedded in the membrane.
21	106	CDD	cd00130	PAS
21	106	InterPro	IPR000014	PAS domain
174	193	TMHMM	TMhelix	Region of a membrane-bound protein predicted to be embedded in the membrane.
436	498	ProSiteProfiles	PS50192	t-SNARE coiled-coil homology domain profile.
436	498	InterPro	IPR000727	Target SNARE coiled-coil homology domain
241	521	SUPERFAMILY	SSF58104	Methyl-accepting chemotaxis protein (MCP) signaling domain
12	142	FunFam	G3DSA:3.30.450.20:FF:000046	Aerotaxis sensor receptor
173	193	Phobius	TRANSMEMBRANE	Region of a membrane-bound protein predicted to be embedded in the membrane.
6	136	Gene3D	G3DSA:3.30.450.20	PAS domain

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

Loading 3D structure...

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Structural evidence

0 + 1

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry	Method	Resolution	Chain	Coverage	Links	Status
AlphaFold PA1561	AlphaFold	—	—	full sequence	—	Viewing

Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET	Sticks	Spheres	Surfaces	Druggability	Labels	Zoom	Positions
1				0.737
5				0.494
7				0.29
18				0.28

PA1561