Protein profile

PA1564

sulfurtransferase TusA

Genome: NC_002516.2

Gene: PA1564 tusA Structure source: AlphaFold UniProt Q9I3F3
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Amino acids 79
Annotations 3
Features 13
PDB binders 0
Druggability 0.629

Overview

Basic information about this protein and its source genome.

Accession
PA1564
Assembly
Pseudomonas aeruginosa PAO1, complete genome
Gene
PA1564 tusA
Status
annotated
Amino acids
79
Structure source
AlphaFold
GO
GO:0005737 The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. GO:0097163 Covalently binding to sulfur and delivering it to an acceptor molecule. GO:0002143 The process in which a uridine residue at position 34 in the anticodon of a tRNA is post-transcriptionally thiolated at the C2 position. This process involves transfer of a sulfur from cysteine to position C2 by several steps.

Target profile

Computed evidence for target prioritization.

Human off-target
No hit
Gut microbiome off-target
hit
Essential (DEG)
Y
Localization
Cytoplasmic

Selected Druggability evidence

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.629
Structure –
Pocket –

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

3 GO

Gene Ontology (GO)

3
  • GO:0005737 The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
  • GO:0097163 Covalently binding to sulfur and delivering it to an acceptor molecule.
  • GO:0002143 The process in which a uridine residue at position 34 in the anticodon of a tRNA is post-transcriptionally thiolated at the C2 position. This process involves transfer of a sulfur from cysteine to position C2 by several steps.

Sequence Features

Domain/signature hits from InterPro and related databases.

13 records
Show feature table
Start End DB Term Name
1 78 Hamap MF_00413 Sulfur carrier protein TusA [tusA].
1 78 InterPro IPR022931 Sulfur carrier protein TusA
4 76 SUPERFAMILY SSF64307 SirA-like
4 76 InterPro IPR036868 TusA-like domain superfamily
5 77 PANTHER PTHR33279 SULFUR CARRIER PROTEIN YEDF-RELATED
1 77 Gene3D G3DSA:3.30.110.40 -
1 77 InterPro IPR036868 TusA-like domain superfamily
8 76 CDD cd03423 SirA
8 76 InterPro IPR022931 Sulfur carrier protein TusA
9 33 ProSitePatterns PS01148 Uncharacterized protein family UPF0033 signature.
9 33 InterPro IPR001455 TusA-like domain
8 76 Pfam PF01206 Sulfurtransferase TusA
8 76 InterPro IPR001455 TusA-like domain

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

3D visualization script Full viewer

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Structural evidence

0 + 1

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry Method Resolution Chain Coverage Links Status
AlphaFold PA1564
AlphaFold — — full sequence — Viewing
Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET Sticks Spheres Surfaces Druggability Labels Zoom Positions
1 0.629