Target Pathogen

Overview

Basic information about this protein and its source genome.

Accession: PA1565
Assembly: Pseudomonas aeruginosa PAO1, complete genome
Gene: PA1565
Status: annotated
Amino acids: 436
Structure source: AlphaFold

GO

GO:0005737 The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. GO:0016491 Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. GO:0006598 The chemical reactions and pathways resulting in the breakdown of polyamines, any organic compound containing two or more amino groups.

Target profile

Computed evidence for target prioritization.

Human off-target: No hit
Gut microbiome off-target: hit
Essential (DEG): N
Localization: Cytoplasmic

Selected Druggability evidence

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.667

Structure –

Pocket –

Sequence

Primary amino-acid sequence viewer.

MNAAIHPRPAAERAPSYYAATLNEETDYPTLLGAVTVDIAIIGGGFTGVATAVELAERGYKVALVETHRIGWGASGRNGGQVTGSLSGDAAMHKQMRQWLGAEVEDFIWHLRWRGHEIIRQRVEKYGIACDLRHGHLHAAMKASHMGELQASYEEAVRRGMGDQVVLLDKAGVQAHLETELYCGALKNTRNMHLHPLNLCIGEARAAAGLGALIFEHSEVLDIVHGPRPAVITREGRIEAQQILLAGDVYHKLERRQLKGMIFPAMGGIVTTRPLGELAREINPQGLAVYDCRFVLDYYRPTADGRLLFGGGANYSGRDSRDITAELRPCIERTFPRLKGVEIEFQWSCAMGIVMNRIPQLGKLSDNVWYCQGYSGHGVATSHIMGEIMAKAMSGSLEQFDTFARCKHLRVPLGDLFGNPMLAAGMWYYQLMEKLR

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

3 GO

Gene Ontology (GO)

3

GO:0005737 The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
GO:0016491 Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced.
GO:0006598 The chemical reactions and pathways resulting in the breakdown of polyamines, any organic compound containing two or more amino groups.

Sequence Features

Domain/signature hits from InterPro and related databases.

8 records

Show feature table

Start	End	DB	Term	Name
133	354	Gene3D	G3DSA:3.30.9.10	-
38	393	Gene3D	G3DSA:3.50.50.60	-
38	393	InterPro	IPR036188	FAD/NAD(P)-binding domain superfamily
37	413	SUPERFAMILY	SSF51905	FAD/NAD(P)-binding domain
37	413	InterPro	IPR036188	FAD/NAD(P)-binding domain superfamily
37	394	PANTHER	PTHR13847	SARCOSINE DEHYDROGENASE-RELATED
38	391	Pfam	PF01266	FAD dependent oxidoreductase
38	391	InterPro	IPR006076	FAD dependent oxidoreductase

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

Loading 3D structure...

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Structural evidence

0 + 1

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry	Method	Resolution	Chain	Coverage	Links	Status
AlphaFold PA1565	AlphaFold	—	—	full sequence	—	Viewing

Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET	Sticks	Spheres	Surfaces	Druggability	Labels	Zoom	Positions
1				0.667
7				0.464

PA1565