Target Pathogen

Overview

Basic information about this protein and its source genome.

Accession: PA1572
Assembly: Pseudomonas aeruginosa PAO1, complete genome
Gene: PA1572
Status: annotated
Amino acids: 381
Structure source: AlphaFold

GO

GO:0005524 Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. GO:0051287 Binding to nicotinamide adenine dinucleotide, a coenzyme involved in many redox and biosynthetic reactions; binding may be to either the oxidized form, NAD+, or the reduced form, NADH. GO:0003951 Catalysis of the reaction: ATP + NAD+ = ADP + H+ + NADP+. GO:0006741 The chemical reactions and pathways resulting in the formation of nicotinamide adenine dinucleotide phosphate (NADP+), a coenzyme that interconverts with its reduced form, NADPH, in many redox and biosynthetic reactions.

Target profile

Computed evidence for target prioritization.

Human off-target: No hit
Gut microbiome off-target: hit
Essential (DEG): N
Localization: Cytoplasmic

Selected Druggability evidence

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.526

Structure –

Pocket –

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

4 GO

Gene Ontology (GO)

4

GO:0005524 Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
GO:0051287 Binding to nicotinamide adenine dinucleotide, a coenzyme involved in many redox and biosynthetic reactions; binding may be to either the oxidized form, NAD+, or the reduced form, NADH.
GO:0003951 Catalysis of the reaction: ATP + NAD+ = ADP + H+ + NADP+.
GO:0006741 The chemical reactions and pathways resulting in the formation of nicotinamide adenine dinucleotide phosphate (NADP+), a coenzyme that interconverts with its reduced form, NADPH, in many redox and biosynthetic reactions.

Sequence Features

Domain/signature hits from InterPro and related databases.

14 records

Show feature table

Start	End	DB	Term	Name
2	371	PIRSF	PIRSF016907	Kin_ATP-NAD
2	371	InterPro	IPR011386	Putative ATP-NAD kinase
1	377	PANTHER	PTHR40697	ACETOIN CATABOLISM PROTEIN X
1	377	InterPro	IPR039065	AcoX-like
6	16	Phobius	SIGNAL_PEPTIDE_H_REGION	Hydrophobic region of a signal peptide.
17	34	Phobius	SIGNAL_PEPTIDE_C_REGION	C-terminal region of a signal peptide.
1	34	Phobius	SIGNAL_PEPTIDE	Signal peptide region
232	368	Pfam	PF20143	ATP-NAD kinase C-terminal domain
1	5	Phobius	SIGNAL_PEPTIDE_N_REGION	N-terminal region of a signal peptide.
35	381	Phobius	NON_CYTOPLASMIC_DOMAIN	Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.
6	165	Pfam	PF01513	ATP-NAD kinase N-terminal domain
6	165	InterPro	IPR002504	NAD kinase
91	174	SUPERFAMILY	SSF111331	NAD kinase/diacylglycerol kinase-like
91	174	InterPro	IPR016064	NAD kinase/diacylglycerol kinase-like domain superfamily

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

Loading 3D structure...

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Structural evidence

0 + 1

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry	Method	Resolution	Chain	Coverage	Links	Status
AlphaFold PA1572	AlphaFold	—	—	full sequence	—	Viewing

Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET	Sticks	Spheres	Surfaces	Druggability	Labels	Zoom	Positions
2				0.526
5				0.216

PA1572