Protein profile

PA1575

hypothetical protein

Genome: NC_002516.2

Gene: PA1575 Structure source: AlphaFold UniProt Q9I3E2

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Amino acids 183

Annotations 3

Features 11

PDB binders 1

Druggability 0.869

Overview

Basic information about this protein and its source genome.

Accession: PA1575
Assembly: Pseudomonas aeruginosa PAO1, complete genome
Gene: PA1575
Status: annotated
Amino acids: 183
Structure source: AlphaFold

GO:0000175 Catalysis of the sequential cleavage of mononucleotides from a free 3' terminus of an RNA molecule. GO:0003676 Binding to a nucleic acid. GO:0006259 Any cellular metabolic process involving deoxyribonucleic acid. This is one of the two main types of nucleic acid, consisting of a long, unbranched macromolecule formed from one, or more commonly, two, strands of linked deoxyribonucleotides.

Target profile

Computed evidence for target prioritization.

Human off-target: hit
Human identity (%): 34.884
Human E-value: 7.56e-11
Gut microbiome off-target: hit
Essential (DEG): N
Localization: Cytoplasmic

Selected Druggability evidence

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.869

Structure –

Pocket –

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

3 GO

Gene Ontology (GO)

GO:0000175 Catalysis of the sequential cleavage of mononucleotides from a free 3' terminus of an RNA molecule.
GO:0003676 Binding to a nucleic acid.
GO:0006259 Any cellular metabolic process involving deoxyribonucleic acid. This is one of the two main types of nucleic acid, consisting of a long, unbranched macromolecule formed from one, or more commonly, two, strands of linked deoxyribonucleotides.

Sequence Features

Domain/signature hits from InterPro and related databases.

11 records

Show feature table

Start	End	DB	Term	Name
3	183	SMART	SM00479	exoiiiendus
3	183	InterPro	IPR013520	Exonuclease, RNase T/DNA polymerase III
5	175	Pfam	PF00929	Exonuclease
5	175	InterPro	IPR013520	Exonuclease, RNase T/DNA polymerase III
5	179	CDD	cd06133	ERI-1_3'hExo_like
5	179	InterPro	IPR047201	ERI-1-like, DEDDh 3'-5' exonuclease domain
1	180	Gene3D	G3DSA:3.30.420.10	-
1	180	InterPro	IPR036397	Ribonuclease H superfamily
3	175	PANTHER	PTHR23044	3'-5' EXONUCLEASE ERI1-RELATED
2	178	SUPERFAMILY	SSF53098	Ribonuclease H-like
2	178	InterPro	IPR012337	Ribonuclease H-like superfamily

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

Loading 3D structure...

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Structural evidence

0 + 1

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry	Method	Resolution	Chain	Coverage	Links	Status
AlphaFold PA1575	AlphaFold	—	—	full sequence	—	Viewing

Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET	Sticks	Spheres	Surfaces	Druggability	Labels	Zoom	Positions
1				0.869
2				0.233

Ligand evidence

Ligands grouped by evidence source. PDB ligands keep the source crystal visible, and loaded crystals can be opened directly in the structure viewer.

55 records

Highest-confidence structural evidence: ligands co-crystallized with this exact protein. If the source PDB is loaded in TPW, use Open crystal to inspect it in the structure viewer.

No PDB structure with a co-crystallized ligand found for this exact protein.

Structural evidence inferred from similar proteins. The source crystal indicates where the ligand was observed; the UniProt column identifies the homologous protein carrying that ligand.

Ligand	Source crystal	UniProt (homolog)	MW · LogP · TPSA	Lipinski	PAINS	SMILES
ER3	3CM6	Q10905	167.3 Da LogP 0.00 TPSA 0.0	✓ Ro5	✓ Clean	`[Er+3]`

Experimental bioactivity from ChEMBL measured directly on this protein. Score = pchembl (−log Ki/IC₅₀; higher = more potent).

No ChEMBL bioactivity data found for this exact protein.

Bioactivity inferred from similar proteins in ChEMBL. Score = pchembl (−log Ki/IC₅₀; higher = more potent).

Ligand	UniProt (homolog)	pchembl	MW · LogP · TPSA	Lipinski	PAINS	SMILES
CHEMBL1644887	Q10905	—	393.5 Da LogP 4.95 TPSA 75.6	✓ Ro5	✓ Clean	`O=C(N[C@H](CC1CCCCC1)C(=O)O)OCC1c2ccccc2-c2cccc…`
CHEMBL395814	Q10905	—	396.4 Da LogP 3.70 TPSA 160.9	✓ Ro5	✓ Clean	`O=C(O)c1cc(SSc2ccc([N+](=O)[O-])c(C(=O)O)c2)ccc…`
CHEMBL3961418	Q10905	—	518.4 Da LogP -2.36 TPSA 179.6	1 viol.	Alert	`O=S(=O)([O-])c1cc(O)c2c(O)c(/N=N/c3cccc4ccccc34…`
QU4	Q10905	—	422.3 Da LogP 2.45 TPSA 169.4	✓ Ro5	✓ Clean	`c1cc(c(cc1C(=C2C=CC(=O)C(=C2)C(=O)O)c3ccc(c(c3)…`

Proposed virtual-screening candidates from ZINC. Score = Tanimoto similarity to a known binder (0–1; higher = more similar).

Ligand	Tanimoto	MW · LogP · TPSA	Lipinski	PAINS	SMILES
ZINC3833863	1.000	422.3 Da LogP 2.45 TPSA 169.4	✓ Ro5	✓ Clean	`O=C(O)C1=CC(=C(c2ccc(O)c(C(=O)O)c2)c2ccc(O)c(C(…`
ZINC621923	1.000	393.5 Da LogP 4.95 TPSA 75.6	✓ Ro5	✓ Clean	`O=C(N[C@@H](CC1CCCCC1)C(=O)O)OCC1c2ccccc2-c2ccc…`
ZINC621924	1.000	393.5 Da LogP 4.95 TPSA 75.6	✓ Ro5	✓ Clean	`O=C(N[C@H](CC1CCCCC1)C(=O)O)OCC1c2ccccc2-c2cccc…`
ZINC2383885	0.976	379.5 Da LogP 4.56 TPSA 75.6	✓ Ro5	✓ Clean	`O=C(N[C@H](CC1CCCC1)C(=O)O)OCC1c2ccccc2-c2ccccc…`
ZINC2583170	0.976	379.5 Da LogP 4.56 TPSA 75.6	✓ Ro5	✓ Clean	`O=C(N[C@@H](CC1CCCC1)C(=O)O)OCC1c2ccccc2-c2cccc…`
ZINC14632633	0.930	365.4 Da LogP 4.17 TPSA 75.6	✓ Ro5	✓ Clean	`O=C(N[C@H](CC1CCC1)C(=O)O)OCC1c2ccccc2-c2ccccc21`
ZINC14632634	0.930	365.4 Da LogP 4.17 TPSA 75.6	✓ Ro5	✓ Clean	`O=C(N[C@@H](CC1CCC1)C(=O)O)OCC1c2ccccc2-c2ccccc…`
ZINC2392277	0.884	351.4 Da LogP 3.78 TPSA 75.6	✓ Ro5	✓ Clean	`O=C(N[C@H](CC1CC1)C(=O)O)OCC1c2ccccc2-c2ccccc21`
ZINC2569788	0.884	351.4 Da LogP 3.78 TPSA 75.6	✓ Ro5	✓ Clean	`O=C(N[C@@H](CC1CC1)C(=O)O)OCC1c2ccccc2-c2ccccc21`
ZINC15446438	0.792	395.5 Da LogP 3.80 TPSA 84.9	✓ Ro5	✓ Clean	`O=C(N[C@H](CC1CCOCC1)C(=O)O)OCC1c2ccccc2-c2cccc…`
ZINC2583448	0.792	394.5 Da LogP 3.37 TPSA 87.7	✓ Ro5	✓ Clean	`O=C(N[C@@H](CC1CCNCC1)C(=O)O)OCC1c2ccccc2-c2ccc…`
ZINC2583457	0.792	395.5 Da LogP 3.80 TPSA 84.9	✓ Ro5	✓ Clean	`O=C(N[C@@H](CC1CCOCC1)C(=O)O)OCC1c2ccccc2-c2ccc…`
ZINC300745717	0.771	393.5 Da LogP 4.95 TPSA 75.6	✓ Ro5	✓ Clean	`O=C(N[C@H](CCC1CCCC1)C(=O)O)OCC1c2ccccc2-c2cccc…`
ZINC300745718	0.771	393.5 Da LogP 4.95 TPSA 75.6	✓ Ro5	✓ Clean	`O=C(N[C@@H](CCC1CCCC1)C(=O)O)OCC1c2ccccc2-c2ccc…`
ZINC226813530	0.765	395.5 Da LogP 3.80 TPSA 84.9	✓ Ro5	✓ Clean	`O=C(N[C@H](C[C@@H]1CCCOC1)C(=O)O)OCC1c2ccccc2-c…`
ZINC226813538	0.765	395.5 Da LogP 3.80 TPSA 84.9	✓ Ro5	✓ Clean	`O=C(N[C@@H](C[C@@H]1CCCOC1)C(=O)O)OCC1c2ccccc2-…`
ZINC226813547	0.765	395.5 Da LogP 3.80 TPSA 84.9	✓ Ro5	✓ Clean	`O=C(N[C@H](C[C@H]1CCCOC1)C(=O)O)OCC1c2ccccc2-c2…`
ZINC226813554	0.765	395.5 Da LogP 3.80 TPSA 84.9	✓ Ro5	✓ Clean	`O=C(N[C@@H](C[C@H]1CCCOC1)C(=O)O)OCC1c2ccccc2-c…`
ZINC7814925	0.758	213.2 Da LogP 2.01 TPSA 80.4	✓ Ro5	✓ Clean	`CSc1ccc([N+](=O)[O-])c(C(=O)O)c1`
ZINC2054344316	0.756	300.3 Da LogP 2.01 TPSA 111.9	✓ Ro5	✓ Clean	`CC(=C1C=CC(=O)C(C(=O)O)=C1)c1ccc(O)c(C(=O)O)c1`
ZINC28092924	0.756	300.3 Da LogP 2.01 TPSA 111.9	✓ Ro5	✓ Clean	`C/C(=C1/C=CC(=O)C(C(=O)O)=C1)c1ccc(O)c(C(=O)O)c1`
ZINC36748824	0.756	300.3 Da LogP 2.01 TPSA 111.9	✓ Ro5	✓ Clean	`C/C(=C1\C=CC(=O)C(C(=O)O)=C1)c1ccc(O)c(C(=O)O)c1`
ZINC1307276081	0.755	407.5 Da LogP 4.36 TPSA 75.6	✓ Ro5	✓ Clean	`O=C(CN[C@@H](CC1CCCCC1)C(=O)O)OCC1c2ccccc2-c2cc…`
ZINC1952055770	0.745	436.5 Da LogP 3.63 TPSA 95.9	✓ Ro5	✓ Clean	`CC(=O)N1CCC(C[C@H](NC(=O)OCC2c3ccccc3-c3ccccc32…`
ZINC383359601	0.740	401.4 Da LogP 4.41 TPSA 75.6	✓ Ro5	✓ Clean	`O=C(N[C@@H](CC1CC(F)(F)C1)C(=O)O)OCC1c2ccccc2-c…`
ZINC383359608	0.740	401.4 Da LogP 4.41 TPSA 75.6	✓ Ro5	✓ Clean	`O=C(N[C@H](CC1CC(F)(F)C1)C(=O)O)OCC1c2ccccc2-c2…`
ZINC398748260	0.735	379.5 Da LogP 4.56 TPSA 75.6	✓ Ro5	✓ Clean	`O=C(N[C@@H](CCC1CCC1)C(=O)O)OCC1c2ccccc2-c2cccc…`
ZINC398748261	0.735	379.5 Da LogP 4.56 TPSA 75.6	✓ Ro5	✓ Clean	`O=C(N[C@H](CCC1CCC1)C(=O)O)OCC1c2ccccc2-c2ccccc…`
ZINC100134232	0.731	474.5 Da LogP 4.31 TPSA 173.9	✓ Ro5	Alert	`O=S(=O)(O)c1cc(O)c2c(O)c(/N=N\c3cccc4ccccc34)c(…`
ZINC261143437	0.731	474.5 Da LogP 4.31 TPSA 173.9	✓ Ro5	Alert	`O=S(=O)(O)c1cc(O)c2c(O)c(N=Nc3cccc4ccccc34)c(S(…`
ZINC3954003	0.731	474.5 Da LogP 4.31 TPSA 173.9	✓ Ro5	Alert	`O=S(=O)(O)c1cc(O)c2c(O)c(/N=N/c3cccc4ccccc34)c(…`
ZINC226811544	0.725	381.4 Da LogP 3.40 TPSA 84.9	✓ Ro5	✓ Clean	`O=C(N[C@H](C[C@@H]1CCOC1)C(=O)O)OCC1c2ccccc2-c2…`
ZINC226811548	0.725	381.4 Da LogP 3.40 TPSA 84.9	✓ Ro5	✓ Clean	`O=C(N[C@@H](C[C@@H]1CCOC1)C(=O)O)OCC1c2ccccc2-c…`
ZINC226811554	0.725	381.4 Da LogP 3.40 TPSA 84.9	✓ Ro5	✓ Clean	`O=C(N[C@H](C[C@H]1CCOC1)C(=O)O)OCC1c2ccccc2-c2c…`
ZINC226811559	0.725	381.4 Da LogP 3.40 TPSA 84.9	✓ Ro5	✓ Clean	`O=C(N[C@@H](C[C@H]1CCOC1)C(=O)O)OCC1c2ccccc2-c2…`
ZINC44320269	0.725	391.5 Da LogP 4.72 TPSA 75.6	✓ Ro5	✓ Clean	`O=C(N[C@H](C[C@H]1CC=CCC1)C(=O)O)OCC1c2ccccc2-c…`
ZINC44320271	0.725	391.5 Da LogP 4.72 TPSA 75.6	✓ Ro5	✓ Clean	`O=C(N[C@H](C[C@@H]1CC=CCC1)C(=O)O)OCC1c2ccccc2-…`
ZINC226811355	0.712	395.5 Da LogP 3.94 TPSA 84.9	✓ Ro5	✓ Clean	`O=C(N[C@H](C[C@@H]1CCCCO1)C(=O)O)OCC1c2ccccc2-c…`
ZINC226811360	0.712	395.5 Da LogP 3.94 TPSA 84.9	✓ Ro5	✓ Clean	`O=C(N[C@@H](C[C@@H]1CCCCO1)C(=O)O)OCC1c2ccccc2-…`
ZINC226811366	0.712	395.5 Da LogP 3.94 TPSA 84.9	✓ Ro5	✓ Clean	`O=C(N[C@H](C[C@H]1CCCCO1)C(=O)O)OCC1c2ccccc2-c2…`
ZINC226811373	0.712	395.5 Da LogP 3.94 TPSA 84.9	✓ Ro5	✓ Clean	`O=C(N[C@@H](C[C@H]1CCCCO1)C(=O)O)OCC1c2ccccc2-c…`
ZINC1036845	0.708	379.5 Da LogP 4.56 TPSA 75.6	✓ Ro5	✓ Clean	`O=C(N[C@H](C(=O)O)C1CCCCC1)OCC1c2ccccc2-c2ccccc…`
ZINC1036846	0.708	379.5 Da LogP 4.56 TPSA 75.6	✓ Ro5	✓ Clean	`O=C(N[C@@H](C(=O)O)C1CCCCC1)OCC1c2ccccc2-c2cccc…`
ZINC113262268	0.708	393.5 Da LogP 4.95 TPSA 75.6	✓ Ro5	✓ Clean	`O=C(N[C@H](C(=O)O)C1CCCCCC1)OCC1c2ccccc2-c2cccc…`
ZINC113262270	0.708	393.5 Da LogP 4.95 TPSA 75.6	✓ Ro5	✓ Clean	`O=C(N[C@@H](C(=O)O)C1CCCCCC1)OCC1c2ccccc2-c2ccc…`
ZINC504215164	0.704	478.5 Da LogP 4.40 TPSA 105.2	✓ Ro5	✓ Clean	`C=CCOC(=O)N1CCC(C[C@H](NC(=O)OCC2c3ccccc3-c3ccc…`
ZINC504215165	0.704	478.5 Da LogP 4.40 TPSA 105.2	✓ Ro5	✓ Clean	`C=CCOC(=O)N1CCC(C[C@@H](NC(=O)OCC2c3ccccc3-c3cc…`
ZINC91690031	0.704	492.6 Da LogP 4.84 TPSA 114.0	✓ Ro5	✓ Clean	`C=CCOC(=O)NC1CCC(C[C@@H](NC(=O)OCC2c3ccccc3-c3c…`
ZINC2556686	0.702	305.4 Da LogP 3.34 TPSA 75.6	✓ Ro5	✓ Clean	`O=C(N[C@H](CC1CCCCC1)C(=O)O)OCc1ccccc1`
ZINC2556687	0.702	305.4 Da LogP 3.34 TPSA 75.6	✓ Ro5	✓ Clean	`O=C(N[C@@H](CC1CCCCC1)C(=O)O)OCc1ccccc1`

PDB and ChEMBL records on this protein are shown in full. ChEMBL records from similar proteins are capped at the top 100 per protein (by pchembl) and ZINC at the top 50 (Tanimoto ≥ 0.5). ADME columns are descriptor-based screening flags, not experimental toxicity results.