Protein profile

PA1593

hypothetical protein

Genome: NC_002516.2

Gene: PA1593 Structure source: Experimental + AlphaFold UniProt Q9I3C8
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Amino acids 157
Annotations 2
Features 10
PDB binders 0
Druggability 0.458

Overview

Basic information about this protein and its source genome.

Accession
PA1593
Assembly
Pseudomonas aeruginosa PAO1, complete genome
Gene
PA1593
Status
annotated
Amino acids
157
Structure source
Experimental + AlphaFold
GO
GO:0005829 The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. GO:0061522 Catalysis of the reaction 1,4-dihydroxy-2-naphthoyl-CoA + H2O = 1,4-dihydroxy-2-naphthoate + CoA + H+.

Target profile

Computed evidence for target prioritization.

Human off-target
No hit
Gut microbiome off-target
hit
Essential (DEG)
N
Localization
Cytoplasmic

Selected Druggability evidence

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.458
Structure –
Pocket –

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

2 GO

Gene Ontology (GO)

2
  • GO:0005829 The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
  • GO:0061522 Catalysis of the reaction 1,4-dihydroxy-2-naphthoyl-CoA + H2O = 1,4-dihydroxy-2-naphthoate + CoA + H+.

Sequence Features

Domain/signature hits from InterPro and related databases.

10 records
Show feature table
Start End DB Term Name
1 139 SUPERFAMILY SSF54637 Thioesterase/thiol ester dehydrase-isomerase
1 139 InterPro IPR029069 HotDog domain superfamily
52 127 Pfam PF03061 Thioesterase superfamily
52 127 InterPro IPR006683 Thioesterase domain
20 153 PANTHER PTHR43240 1,4-DIHYDROXY-2-NAPHTHOYL-COA THIOESTERASE 1
23 138 CDD cd03443 PaaI_thioesterase
3 142 Gene3D G3DSA:3.10.129.10 Hotdog Thioesterase
20 112 NCBIfam TIGR00369 hotdog fold thioesterase
20 112 InterPro IPR003736 Phenylacetic acid degradation-related domain
3 148 FunFam G3DSA:3.10.129.10:FF:000129 PaaI family thioesterase

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

3D visualization script Full viewer

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Structural evidence

1 + 1

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry Method Resolution Chain Coverage Links Status
PDB 3F1T
X-ray 2.20 Å A,B,C,D
89.2% 1-140
PDBe RCSB PDBj File
Viewing
AlphaFold PA1593
AlphaFold — — full sequence — Loaded
Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET Sticks Spheres Surfaces Druggability Labels Zoom Positions
2 0.458