Protein profile

PA1594

hypothetical protein

Genome: NC_002516.2

Gene: PA1594 Structure source: AlphaFold UniProt Q9I3C7

Export view

Amino acids 148

Annotations 1

Features 7

PDB binders 0

Druggability 0.938

Overview

Basic information about this protein and its source genome.

Accession: PA1594
Assembly: Pseudomonas aeruginosa PAO1, complete genome
Gene: PA1594
Status: annotated
Amino acids: 148
Structure source: AlphaFold

GO:0016790 Catalysis of the reaction: RCO-SR' + H2O = RCOOH + HSR'. This reaction is the hydrolysis of a thiolester bond, an ester formed from a carboxylic acid and a thiol (i.e., RCO-SR'), such as that found in acetyl-coenzyme A.

Target profile

Computed evidence for target prioritization.

Human off-target: No hit
Gut microbiome off-target: hit
Essential (DEG): N
Localization: Unknown

Selected Druggability evidence

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.938

Structure –

Pocket –

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

1 GO

Gene Ontology (GO)

GO:0016790 Catalysis of the reaction: RCO-SR' + H2O = RCOOH + HSR'. This reaction is the hydrolysis of a thiolester bond, an ester formed from a carboxylic acid and a thiol (i.e., RCO-SR'), such as that found in acetyl-coenzyme A.

Sequence Features

Domain/signature hits from InterPro and related databases.

7 records

Show feature table

Start	End	DB	Term	Name
23	143	PANTHER	PTHR43240	1,4-DIHYDROXY-2-NAPHTHOYL-COA THIOESTERASE 1
62	134	Pfam	PF03061	Thioesterase superfamily
62	134	InterPro	IPR006683	Thioesterase domain
12	145	SUPERFAMILY	SSF54637	Thioesterase/thiol ester dehydrase-isomerase
12	145	InterPro	IPR029069	HotDog domain superfamily
31	145	CDD	cd03443	PaaI_thioesterase
4	147	Gene3D	G3DSA:3.10.129.10	Hotdog Thioesterase

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

Loading 3D structure...

Legend High Medium Low

Structural evidence

0 + 1

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry	Method	Resolution	Chain	Coverage	Links	Status
AlphaFold PA1594	AlphaFold	—	—	full sequence	—	Viewing

Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET	Sticks	Spheres	Surfaces	Druggability	Labels	Zoom	Positions
6				0.938