Protein profile

PA1599

transcriptional regulator

Genome: NC_002516.2

Gene: PA1599 Structure source: AlphaFold UniProt Q9I3C2
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Amino acids 260
Annotations 5
Features 24
PDB binders 0
Druggability 0.7

Overview

Basic information about this protein and its source genome.

Accession
PA1599
Assembly
Pseudomonas aeruginosa PAO1, complete genome
Gene
PA1599
Status
annotated
Amino acids
260
Structure source
AlphaFold
GO
GO:0003677 Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid). GO:0003700 A transcription regulator activity that modulates transcription of gene sets via selective and non-covalent binding to a specific double-stranded genomic DNA sequence (sometimes referred to as a motif) within a cis-regulatory region. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units, and include bacterial operons. GO:0043565 Binding to DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding. GO:0009893 Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways within a cell or an organism. GO:0006355 Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription.

Target profile

Computed evidence for target prioritization.

Human off-target
No hit
Gut microbiome off-target
hit
Essential (DEG)
N
Localization
Cytoplasmic

Selected Druggability evidence

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.7
Structure –
Pocket –

Sequence

Primary amino-acid sequence viewer.

MPQTGQERDLPRFRSLPCAVYLRAFEMPAGHRVEMHDHPWGQLMYAASGTLRASTERHSYLVPAQRALWIPPGVRHAAEACNPVLFRSLYLDRSLPGGCRVLEVSGLLRELLLRAAEFPREYPPGGEAERLMQVVADEVGRLREAPLNLPLPGDPRLRRITDALQADPADPRGISDWAGLVGASRRTLARLFREQTQLSFREWRQRLRLLNAVAALEEGASVTRVASDLGYDSTSAFISLFQRHFGQTPGCFARSLRLPN

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

5 GO

Gene Ontology (GO)

5
  • GO:0003677 Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid).
  • GO:0003700 A transcription regulator activity that modulates transcription of gene sets via selective and non-covalent binding to a specific double-stranded genomic DNA sequence (sometimes referred to as a motif) within a cis-regulatory region. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units, and include bacterial operons.
  • GO:0043565 Binding to DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding.
  • GO:0009893 Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways within a cell or an organism.
  • GO:0006355 Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription.

Sequence Features

Domain/signature hits from InterPro and related databases.

24 records
Show feature table
Start End DB Term Name
158 255 ProSiteProfiles PS01124 Bacterial regulatory proteins, araC family DNA-binding domain profile.
158 255 InterPro IPR018060 DNA binding HTH domain, AraC-type
152 256 FunFam G3DSA:1.10.10.60:FF:000132 AraC family transcriptional regulator
237 253 PRINTS PR00032 AraC bacterial regulatory protein HTH signature
237 253 InterPro IPR020449 Transcription regulator HTH, AraC- type
222 237 PRINTS PR00032 AraC bacterial regulatory protein HTH signature
222 237 InterPro IPR020449 Transcription regulator HTH, AraC- type
26 92 Pfam PF02311 AraC-like ligand binding domain
26 92 InterPro IPR003313 AraC-type arabinose-binding/dimerisation domain
6 255 PANTHER PTHR11019 HTH-TYPE TRANSCRIPTIONAL REGULATOR NIMR
15 90 Gene3D G3DSA:2.60.120.10 Jelly Rolls
15 90 InterPro IPR014710 RmlC-like jelly roll fold
177 254 Pfam PF12833 Helix-turn-helix domain
177 254 InterPro IPR018060 DNA binding HTH domain, AraC-type
5 180 SUPERFAMILY SSF51182 RmlC-like cupins
5 180 InterPro IPR011051 RmlC-like cupin domain superfamily
20 105 CDD cd06124 cupin_NimR-like_N
208 249 ProSitePatterns PS00041 Bacterial regulatory proteins, araC family signature.
208 249 InterPro IPR018062 HTH domain AraC-type, conserved site
207 256 SUPERFAMILY SSF46689 Homeodomain-like
207 256 InterPro IPR009057 Homeobox-like domain superfamily
171 253 SMART SM00342 aracneu4
171 253 InterPro IPR018060 DNA binding HTH domain, AraC-type
152 256 Gene3D G3DSA:1.10.10.60 -

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

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Structural evidence

0 + 1

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry Method Resolution Chain Coverage Links Status
AlphaFold PA1599
AlphaFold — — full sequence — Viewing
Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET Sticks Spheres Surfaces Druggability Labels Zoom Positions
6 0.7
2 0.202