Protein profile

PA1603

transcriptional regulator

Genome: NC_002516.2

Gene: PA1603 Structure source: Experimental + AlphaFold UniProt Q9I3B8
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Amino acids 140
Annotations 3
Features 19
PDB binders 3
Druggability 0.651

Overview

Basic information about this protein and its source genome.

Accession
PA1603
Assembly
Pseudomonas aeruginosa PAO1, complete genome
Gene
PA1603
Status
annotated
Amino acids
140
Structure source
Experimental + AlphaFold
GO
GO:0003700 A transcription regulator activity that modulates transcription of gene sets via selective and non-covalent binding to a specific double-stranded genomic DNA sequence (sometimes referred to as a motif) within a cis-regulatory region. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units, and include bacterial operons. GO:0006355 Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription. GO:0006950 Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a disturbance in organismal or cellular homeostasis, usually, but not necessarily, exogenous (e.g. temperature, humidity, ionizing radiation).

Target profile

Computed evidence for target prioritization.

Human off-target
No hit
Gut microbiome off-target
hit
Essential (DEG)
N
Localization
Cytoplasmic

Selected Druggability evidence

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.651
Structure –
Pocket –

Sequence

Primary amino-acid sequence viewer.

MSRTTPYRLDDQIGFILRQANQRYAALFANGIGNGLTPTQWAALVRLGETGPCPQNQLGRLTAMDAATIKGVVERLDKRGLIQRSADPDDGRRLLVSLSPAGRAELEAGLAAAREINRQALAPLSLQEQETLRGLLARLI

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

3 GO

Gene Ontology (GO)

3
  • GO:0003700 A transcription regulator activity that modulates transcription of gene sets via selective and non-covalent binding to a specific double-stranded genomic DNA sequence (sometimes referred to as a motif) within a cis-regulatory region. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units, and include bacterial operons.
  • GO:0006355 Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription.
  • GO:0006950 Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a disturbance in organismal or cellular homeostasis, usually, but not necessarily, exogenous (e.g. temperature, humidity, ionizing radiation).

Sequence Features

Domain/signature hits from InterPro and related databases.

19 records
Show feature table
Start End DB Term Name
36 93 Pfam PF01047 MarR family
36 93 InterPro IPR000835 MarR-type HTH domain
10 140 ProSiteProfiles PS50995 MarR-type HTH domain profile.
10 140 InterPro IPR000835 MarR-type HTH domain
1 140 Gene3D G3DSA:1.10.10.10 -
1 140 InterPro IPR036388 Winged helix-like DNA-binding domain superfamily
89 105 PRINTS PR00598 Bacterial regulatory protein MarR family signature
89 105 InterPro IPR000835 MarR-type HTH domain
70 85 PRINTS PR00598 Bacterial regulatory protein MarR family signature
70 85 InterPro IPR000835 MarR-type HTH domain
119 139 PRINTS PR00598 Bacterial regulatory protein MarR family signature
119 139 InterPro IPR000835 MarR-type HTH domain
29 129 SMART SM00347 marrlong4
29 129 InterPro IPR000835 MarR-type HTH domain
4 140 FunFam G3DSA:1.10.10.10:FF:000576 Transcriptional regulator HosA
10 139 PANTHER PTHR33164 TRANSCRIPTIONAL REGULATOR, MARR FAMILY
10 139 InterPro IPR039422 Transcription regulators MarR/SlyA-like
2 139 SUPERFAMILY SSF46785 Winged helix DNA-binding domain
2 139 InterPro IPR036390 Winged helix DNA-binding domain superfamily

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

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Structural evidence

1 + 1

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry Method Resolution Chain Coverage Links Status
PDB 2NNN
X-ray 2.40 Å A,B,C,D,E,F,G,H,I,J
100.0% 1-140
PDBe RCSB PDBj File
Viewing
AlphaFold PA1603
AlphaFold — — full sequence — Loaded
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Pockets (P2RANK)

Showing top-ranked P2Rank candidates by probability. Probability is color-coded per P2Rank calibration: high (≥ 0.5), medium (0.2 – 0.49), low (< 0.2).

P2RANK Sticks Spheres Surfaces Score Probability Labels Zoom Positions
1 1.87 0.037
2 1.53 0.023

Ligand evidence

Ligands grouped by evidence source. PDB ligands keep the source crystal visible, and loaded crystals can be opened directly in the structure viewer.

53 records

Structural evidence inferred from similar proteins. The source crystal indicates where the ligand was observed; the UniProt column identifies the homologous protein carrying that ligand.

Show only:
Ligand Source crystal UniProt (homolog) MW · LogP · TPSA Lipinski PAINS SMILES
DHB
4FHT
Q9XAM6 154.1 Da LogP 0.80 TPSA 77.8 ✓ Ro5 Alert c1cc(c(cc1C(=O)O)O)O
SAL
3BPX
O26413 138.1 Da LogP 1.09 TPSA 57.5 ✓ Ro5 ✓ Clean c1ccc(c(c1)C(=O)O)O
WCA
5CYV
Q0S6D0 913.7 Da LogP 0.08 TPSA 383.9 3 viol. ✓ Clean CC(C)(COP(=O)(O)OP(=O)(O)OC[C@@H]1[C@H]([C@H]([…

PDB and ChEMBL records on this protein are shown in full. ChEMBL records from similar proteins are capped at the top 100 per protein (by pchembl) and ZINC at the top 50 (Tanimoto ≥ 0.5). ADME columns are descriptor-based screening flags, not experimental toxicity results.