Target Pathogen

Overview

Basic information about this protein and its source genome.

Accession: PA1619
Assembly: Pseudomonas aeruginosa PAO1, complete genome
Gene: PA1619
Status: annotated
Amino acids: 274
Structure source: AlphaFold

GO

GO:0005737 The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. GO:0000987 Binding to a specific upstream regulatory DNA sequence (transcription factor recognition sequence or binding site, located in cis relative to the transcription start site (i.e., on the same strand of DNA) of a gene transcribed by some RNA polymerase. Cis-regulatory sites are often referred to as a sequence motifs, enhancers, or silencers. GO:0003700 A transcription regulator activity that modulates transcription of gene sets via selective and non-covalent binding to a specific double-stranded genomic DNA sequence (sometimes referred to as a motif) within a cis-regulatory region. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units, and include bacterial operons. GO:0009893 Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways within a cell or an organism. GO:0006355 Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription. GO:0043565 Binding to DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding.

Target profile

Computed evidence for target prioritization.

Human off-target: No hit
Gut microbiome off-target: hit
Essential (DEG): Y
Localization: Cytoplasmic

Selected Druggability evidence

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.54

Structure –

Pocket –

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

6 GO

Gene Ontology (GO)

6

GO:0005737 The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
GO:0000987 Binding to a specific upstream regulatory DNA sequence (transcription factor recognition sequence or binding site, located in cis relative to the transcription start site (i.e., on the same strand of DNA) of a gene transcribed by some RNA polymerase. Cis-regulatory sites are often referred to as a sequence motifs, enhancers, or silencers.
GO:0003700 A transcription regulator activity that modulates transcription of gene sets via selective and non-covalent binding to a specific double-stranded genomic DNA sequence (sometimes referred to as a motif) within a cis-regulatory region. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units, and include bacterial operons.
GO:0009893 Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways within a cell or an organism.
GO:0006355 Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription.
GO:0043565 Binding to DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding.

Sequence Features

Domain/signature hits from InterPro and related databases.

24 records

Show feature table

Start	End	DB	Term	Name
14	96	Gene3D	G3DSA:2.60.120.10	Jelly Rolls
14	96	InterPro	IPR014710	RmlC-like jelly roll fold
176	223	SUPERFAMILY	SSF46689	Homeodomain-like
176	223	InterPro	IPR009057	Homeobox-like domain superfamily
176	274	ProSiteProfiles	PS01124	Bacterial regulatory proteins, araC family DNA-binding domain profile.
176	274	InterPro	IPR018060	DNA binding HTH domain, AraC-type
12	150	Pfam	PF02311	AraC-like ligand binding domain
12	150	InterPro	IPR003313	AraC-type arabinose-binding/dimerisation domain
226	268	ProSitePatterns	PS00041	Bacterial regulatory proteins, araC family signature.
226	268	InterPro	IPR018062	HTH domain AraC-type, conserved site
174	274	Gene3D	G3DSA:1.10.10.60	-
12	274	PANTHER	PTHR46796	HTH-TYPE TRANSCRIPTIONAL ACTIVATOR RHAS-RELATED
225	274	SUPERFAMILY	SSF46689	Homeodomain-like
225	274	InterPro	IPR009057	Homeobox-like domain superfamily
189	272	SMART	SM00342	aracneu4
189	272	InterPro	IPR018060	DNA binding HTH domain, AraC-type
256	272	PRINTS	PR00032	AraC bacterial regulatory protein HTH signature
256	272	InterPro	IPR020449	Transcription regulator HTH, AraC- type
241	256	PRINTS	PR00032	AraC bacterial regulatory protein HTH signature
241	256	InterPro	IPR020449	Transcription regulator HTH, AraC- type
195	274	Pfam	PF12833	Helix-turn-helix domain
195	274	InterPro	IPR018060	DNA binding HTH domain, AraC-type
22	153	SUPERFAMILY	SSF51215	Regulatory protein AraC
22	153	InterPro	IPR037923	Transcription regulator HTH-like

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

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Structural evidence

0 + 1

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry	Method	Resolution	Chain	Coverage	Links	Status
AlphaFold PA1619	AlphaFold	—	—	full sequence	—	Viewing

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Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET	Sticks	Spheres	Surfaces	Druggability	Labels	Zoom	Positions
1				0.54

PA1619