Protein profile

PA1621

hydrolase

Genome: NC_002516.2

Gene: PA1621 Structure source: AlphaFold UniProt Q9I3A1
Export view
Amino acids 270
Annotations 2
Features 7
PDB binders 0
Druggability 0.748

Overview

Basic information about this protein and its source genome.

Accession
PA1621
Assembly
Pseudomonas aeruginosa PAO1, complete genome
Gene
PA1621
Status
annotated
Amino acids
270
Structure source
AlphaFold
GO
GO:0016020 A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. GO:0016298 Catalysis of the hydrolysis of a lipid.

Target profile

Computed evidence for target prioritization.

Human off-target
No hit
Gut microbiome off-target
hit
Essential (DEG)
N
Localization
Cytoplasmic

Selected Druggability evidence

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.748
Structure –
Pocket –

Sequence

Primary amino-acid sequence viewer.

MSQSVFFAHANGFPSATYAKLFEALAPEYRVDHLEMHGHDPRFPVNDNWDNLVDELLHHLASLEQPVWGVGHSLGGVLHYHAALRRPELYRGVVMLDSPVLTLADRLVIRAAKRFGFIDRITPAGRTLGRREAFPDLEEARAYFSGKALFRRFDPDCLEAYVRHGLADSGGGSGLRLRFDPATEISIYRSVPHSSPGRARQLQVPLAMVRGRHSKVVLPHHTRLIRAMPRGEFMSLPGGHMFPLERPRETAELLKGVFDRWSRATEERSA

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

2 GO

Gene Ontology (GO)

2
  • GO:0016020 A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it.
  • GO:0016298 Catalysis of the hydrolysis of a lipid.

Sequence Features

Domain/signature hits from InterPro and related databases.

7 records
Show feature table
Start End DB Term Name
2 262 Gene3D G3DSA:3.40.50.1820 alpha/beta hydrolase
2 262 InterPro IPR029058 Alpha/Beta hydrolase fold
5 258 SUPERFAMILY SSF53474 alpha/beta-Hydrolases
5 258 InterPro IPR029058 Alpha/Beta hydrolase fold
4 256 PANTHER PTHR43194 HYDROLASE ALPHA/BETA FOLD FAMILY
5 252 Pfam PF12697 Alpha/beta hydrolase family
5 252 InterPro IPR000073 Alpha/beta hydrolase fold-1

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

3D visualization script Full viewer

Loading 3D structure...

Legend High Medium Low

Structural evidence

0 + 1

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry Method Resolution Chain Coverage Links Status
AlphaFold PA1621
AlphaFold — — full sequence — Viewing
Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET Sticks Spheres Surfaces Druggability Labels Zoom Positions
1 0.748