Protein profile

PA1627

transcriptional regulator

Genome: NC_002516.2

Gene: PA1627 Structure source: AlphaFold UniProt Q9I395
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Amino acids 215
Annotations 3
Features 25
PDB binders 1
Druggability 0.76

Overview

Basic information about this protein and its source genome.

Accession
PA1627
Assembly
Pseudomonas aeruginosa PAO1, complete genome
Gene
PA1627
Status
annotated
Amino acids
215
Structure source
AlphaFold
GO
GO:0000987 Binding to a specific upstream regulatory DNA sequence (transcription factor recognition sequence or binding site, located in cis relative to the transcription start site (i.e., on the same strand of DNA) of a gene transcribed by some RNA polymerase. Cis-regulatory sites are often referred to as a sequence motifs, enhancers, or silencers. GO:0003700 A transcription regulator activity that modulates transcription of gene sets via selective and non-covalent binding to a specific double-stranded genomic DNA sequence (sometimes referred to as a motif) within a cis-regulatory region. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units, and include bacterial operons. GO:0006355 Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription.

Target profile

Computed evidence for target prioritization.

Human off-target
No hit
Gut microbiome off-target
hit
Essential (DEG)
N
Localization
Cytoplasmic

Selected Druggability evidence

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.76
Structure –
Pocket –

Sequence

Primary amino-acid sequence viewer.

MTIPLKRSLVDIALEQIRQRIDAGHWPLGQRLPPEPELAELLGMSRNTVREAVRVLTFSGVLEVRQGDGTYVRACADPLETMLVLARSAVQHSLEARGMIEIEAARLAAVRRDDSDLSALREHLDASRQRYGSADLQDYIEHDVRFHQRMVDAAHNPVLSELYRYFSQVIRTSLERTMADPQRAQPCFELHQQLLDAIERGDPDAAAAANRALLI

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

3 GO

Gene Ontology (GO)

3
  • GO:0000987 Binding to a specific upstream regulatory DNA sequence (transcription factor recognition sequence or binding site, located in cis relative to the transcription start site (i.e., on the same strand of DNA) of a gene transcribed by some RNA polymerase. Cis-regulatory sites are often referred to as a sequence motifs, enhancers, or silencers.
  • GO:0003700 A transcription regulator activity that modulates transcription of gene sets via selective and non-covalent binding to a specific double-stranded genomic DNA sequence (sometimes referred to as a motif) within a cis-regulatory region. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units, and include bacterial operons.
  • GO:0006355 Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription.

Sequence Features

Domain/signature hits from InterPro and related databases.

25 records
Show feature table
Start End DB Term Name
15 72 Pfam PF00392 Bacterial regulatory proteins, gntR family
15 72 InterPro IPR000524 Transcription regulator HTH, GntR
8 73 CDD cd07377 WHTH_GntR
8 73 InterPro IPR000524 Transcription regulator HTH, GntR
6 76 SUPERFAMILY SSF46785 Winged helix DNA-binding domain
6 76 InterPro IPR036390 Winged helix DNA-binding domain superfamily
5 77 Gene3D G3DSA:1.10.10.10 -
5 77 InterPro IPR036388 Winged helix-like DNA-binding domain superfamily
86 215 Gene3D G3DSA:1.20.120.530 -
86 215 InterPro IPR008920 Transcription regulator FadR/GntR, C-terminal
13 72 SMART SM00345 gntr3
13 72 InterPro IPR000524 Transcription regulator HTH, GntR
94 214 Pfam PF07729 FCD domain
94 214 InterPro IPR011711 GntR, C-terminal
46 62 PRINTS PR00035 GntR bacterial regulatory protein HTH signature
46 62 InterPro IPR000524 Transcription regulator HTH, GntR
32 46 PRINTS PR00035 GntR bacterial regulatory protein HTH signature
32 46 InterPro IPR000524 Transcription regulator HTH, GntR
91 214 SUPERFAMILY SSF48008 GntR ligand-binding domain-like
91 214 InterPro IPR008920 Transcription regulator FadR/GntR, C-terminal
7 75 ProSiteProfiles PS50949 GntR-type HTH domain profile.
7 75 InterPro IPR000524 Transcription regulator HTH, GntR
92 215 SMART SM00895 FCD_2
92 215 InterPro IPR011711 GntR, C-terminal
7 213 PANTHER PTHR43537 TRANSCRIPTIONAL REGULATOR, GNTR FAMILY

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

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Structural evidence

0 + 1

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry Method Resolution Chain Coverage Links Status
AlphaFold PA1627
AlphaFold — — full sequence — Viewing
Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET Sticks Spheres Surfaces Druggability Labels Zoom Positions
1 0.76
2 0.442

Ligand evidence

Ligands grouped by evidence source. PDB ligands keep the source crystal visible, and loaded crystals can be opened directly in the structure viewer.

18 records

Structural evidence inferred from similar proteins. The source crystal indicates where the ligand was observed; the UniProt column identifies the homologous protein carrying that ligand.

Show only:
Ligand Source crystal UniProt (homolog) MW · LogP · TPSA Lipinski PAINS SMILES
3VV
4PDK
Q9KQU8 1032.0 Da LogP 4.70 TPSA 363.6 3 viol. ✓ Clean CCCCCCCC/C=C\CCCCCCCC(=O)SCCNC(=O)CCNC(=O)[C@@H…

PDB and ChEMBL records on this protein are shown in full. ChEMBL records from similar proteins are capped at the top 100 per protein (by pchembl) and ZINC at the top 50 (Tanimoto ≥ 0.5). ADME columns are descriptor-based screening flags, not experimental toxicity results.