Protein profile

PA1633

potassium-transporting ATPase subunit A

Genome: NC_002516.2

Gene: kdpA PA1633 Structure source: AlphaFold UniProt P57683
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Amino acids 564
Annotations 5
Features 45
PDB binders 0
Druggability 0.938

Overview

Basic information about this protein and its source genome.

Accession
PA1633
Assembly
Pseudomonas aeruginosa PAO1, complete genome
Gene
kdpA PA1633
Status
annotated
Amino acids
564
Structure source
AlphaFold
GO
GO:0005886 The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. GO:0008556 Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + K+(out) = ADP + phosphate + K+(in). GO:0030955 Binding to a potassium ion (K+). GO:0071805 A process in which a potassium ion is transported from one side of a membrane to the other. GO:0006813 The directed movement of potassium ions (K+) into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.

Target profile

Computed evidence for target prioritization.

Human off-target
No hit
Gut microbiome off-target
hit
Essential (DEG)
Y
Localization
CytoplasmicMembrane

Selected Druggability evidence

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.938
Structure –
Pocket –

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

5 GO

Gene Ontology (GO)

5
  • GO:0005886 The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
  • GO:0008556 Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + K+(out) = ADP + phosphate + K+(in).
  • GO:0030955 Binding to a potassium ion (K+).
  • GO:0071805 A process in which a potassium ion is transported from one side of a membrane to the other.
  • GO:0006813 The directed movement of potassium ions (K+) into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.

Sequence Features

Domain/signature hits from InterPro and related databases.

45 records
Show feature table
Start End DB Term Name
558 564 Phobius NON_CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.
487 509 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
120 138 Phobius NON_CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.
1 24 Phobius SIGNAL_PEPTIDE Signal peptide region
139 159 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
3 562 NCBIfam TIGR00680 potassium-transporting ATPase subunit KdpA
3 562 InterPro IPR004623 Potassium-transporting ATPase A chain
177 199 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
1 562 PANTHER PTHR30607 POTASSIUM-TRANSPORTING ATPASE A CHAIN
1 562 InterPro IPR004623 Potassium-transporting ATPase A chain
160 178 Phobius CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the cytoplasm.
375 397 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
66 88 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
443 486 Phobius NON_CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.
306 374 Phobius NON_CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.
25 65 Phobius NON_CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.
401 419 Phobius CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the cytoplasm.
100 119 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
418 440 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
68 90 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
18 24 Phobius SIGNAL_PEPTIDE_C_REGION C-terminal region of a signal peptide.
285 307 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
2 562 Hamap MF_00275 Potassium-transporting ATPase potassium-binding subunit [kdpA].
2 562 InterPro IPR004623 Potassium-transporting ATPase A chain
89 99 Phobius CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the cytoplasm.
510 529 Phobius CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the cytoplasm.
11 560 Pfam PF03814 Potassium-transporting ATPase A subunit
11 560 InterPro IPR004623 Potassium-transporting ATPase A chain
530 552 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
1 5 Phobius SIGNAL_PEPTIDE_N_REGION N-terminal region of a signal peptide.
375 400 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
275 285 Phobius CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the cytoplasm.
256 278 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
199 252 Phobius NON_CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.
487 509 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
6 28 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
6 17 Phobius SIGNAL_PEPTIDE_H_REGION Hydrophobic region of a signal peptide.
1 564 PIRSF PIRSF001294 H/K_exch_ATPase_A
1 564 InterPro IPR004623 Potassium-transporting ATPase A chain
134 156 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
286 305 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
253 274 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
420 442 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
530 557 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
179 198 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

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Structural evidence

0 + 1

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry Method Resolution Chain Coverage Links Status
AlphaFold PA1633
AlphaFold — — full sequence — Viewing
Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET Sticks Spheres Surfaces Druggability Labels Zoom Positions
6 0.938
9 0.637
18 0.479
12 0.304