Protein profile

PA1643

tRNA 2-selenouridine synthase

Genome: NC_002516.2

Gene: selU PA1643 Structure source: AlphaFold UniProt Q9I382

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Amino acids 369

Annotations 4

Features 18

PDB binders 0

Druggability 0.496

Overview

Basic information about this protein and its source genome.

Accession: PA1643
Assembly: Pseudomonas aeruginosa PAO1, complete genome
Gene: selU PA1643
Status: annotated
Amino acids: 369
Structure source: AlphaFold

2.9.1.3

GO:0016765 Catalysis of the transfer of an alkyl or aryl (but not methyl) group from one compound (donor) to another (acceptor). GO:0043828 Catalysis of the reaction: 5-methylaminomethyl-2-thiouridine + selenophosphate = 5-methylaminomethyl-2-selenouridine + phosphate (at the wobble position in tRNA). GO:0002098 The process in which a uridine at position 34 of a tRNA is post-transcriptionally modified. The wobble nucleoside of the tRNA sequence (position 34) corresponds to the first position of the anticodon.

Target profile

Computed evidence for target prioritization.

Human off-target: No hit
Gut microbiome off-target: hit
Essential (DEG): N
Localization: Cytoplasmic

Selected Druggability evidence

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.496

Structure –

Pocket –

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

1 EC 3 GO

Enzyme Commission (EC)

2.9.1.3

Gene Ontology (GO)

GO:0016765 Catalysis of the transfer of an alkyl or aryl (but not methyl) group from one compound (donor) to another (acceptor).
GO:0043828 Catalysis of the reaction: 5-methylaminomethyl-2-thiouridine + selenophosphate = 5-methylaminomethyl-2-selenouridine + phosphate (at the wobble position in tRNA).
GO:0002098 The process in which a uridine at position 34 of a tRNA is post-transcriptionally modified. The wobble nucleoside of the tRNA sequence (position 34) corresponds to the first position of the anticodon.

Sequence Features

Domain/signature hits from InterPro and related databases.

18 records

Show feature table

Start	End	DB	Term	Name
10	156	SUPERFAMILY	SSF52821	Rhodanese/Cell cycle control phosphatase
10	156	InterPro	IPR036873	Rhodanese-like domain superfamily
3	133	FunFam	G3DSA:3.40.250.10:FF:000009	tRNA 2-selenouridine/geranyl-2-thiouridine synthase
145	283	SUPERFAMILY	SSF52540	P-loop containing nucleoside triphosphate hydrolases
145	283	InterPro	IPR027417	P-loop containing nucleoside triphosphate hydrolase
2	133	Gene3D	G3DSA:3.40.250.10	-
2	133	InterPro	IPR036873	Rhodanese-like domain superfamily
12	136	ProSiteProfiles	PS50206	Rhodanese domain profile.
12	136	InterPro	IPR001763	Rhodanese-like domain
1	363	Hamap	MF_01622	tRNA 2-selenouridine synthase [selU].
1	363	InterPro	IPR017582	tRNA 2-selenouridine synthase
15	348	NCBIfam	TIGR03167	tRNA 2-selenouridine(34) synthase MnmH
15	348	InterPro	IPR017582	tRNA 2-selenouridine synthase
3	368	PANTHER	PTHR30401	TRNA 2-SELENOURIDINE SYNTHASE
3	368	InterPro	IPR017582	tRNA 2-selenouridine synthase
2	133	SMART	SM00450	rhod_4
2	133	InterPro	IPR001763	Rhodanese-like domain
8	131	CDD	cd01520	RHOD_YbbB

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

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Structural evidence

0 + 1

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry	Method	Resolution	Chain	Coverage	Links	Status
AlphaFold PA1643	AlphaFold	—	—	full sequence	—	Viewing

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Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET	Sticks	Spheres	Surfaces	Druggability	Labels	Zoom	Positions
2				0.496