Target Pathogen

Overview

Basic information about this protein and its source genome.

Accession: PA1646
Assembly: Pseudomonas aeruginosa PAO1, complete genome
Gene: PA1646
Status: annotated
Amino acids: 652
Structure source: AlphaFold

GO

GO:0005886 The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. GO:0006935 The directed movement of a motile cell or organism, or the directed growth of a cell guided by a specific chemical concentration gradient. Movement may be towards a higher concentration (positive chemotaxis) or towards a lower concentration (negative chemotaxis). GO:0007165 The cellular process in which a signal is conveyed to trigger a change in the activity or state of a cell. Signal transduction begins with reception of a signal (e.g. a ligand binding to a receptor or receptor activation by a stimulus such as light), or for signal transduction in the absence of ligand, signal-withdrawal or the activity of a constitutively active receptor. Signal transduction ends with regulation of a downstream cellular process, e.g. regulation of transcription or regulation of a metabolic process. Signal transduction covers signaling from receptors located on the surface of the cell and signaling via molecules located within the cell. For signaling between cells, signal transduction is restricted to events at and within the receiving cell. GO:0016020 A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it.

Target profile

Computed evidence for target prioritization.

Human off-target: No hit
Gut microbiome off-target: hit
Essential (DEG): N
Localization: CytoplasmicMembrane

Selected Druggability evidence

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.888

Structure –

Pocket –

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

4 GO

Gene Ontology (GO)

4

GO:0005886 The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
GO:0006935 The directed movement of a motile cell or organism, or the directed growth of a cell guided by a specific chemical concentration gradient. Movement may be towards a higher concentration (positive chemotaxis) or towards a lower concentration (negative chemotaxis).
GO:0007165 The cellular process in which a signal is conveyed to trigger a change in the activity or state of a cell. Signal transduction begins with reception of a signal (e.g. a ligand binding to a receptor or receptor activation by a stimulus such as light), or for signal transduction in the absence of ligand, signal-withdrawal or the activity of a constitutively active receptor. Signal transduction ends with regulation of a downstream cellular process, e.g. regulation of transcription or regulation of a metabolic process. Signal transduction covers signaling from receptors located on the surface of the cell and signaling via molecules located within the cell. For signaling between cells, signal transduction is restricted to events at and within the receiving cell.
GO:0016020 A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it.

Sequence Features

Domain/signature hits from InterPro and related databases.

35 records

Show feature table

Start	End	DB	Term	Name
327	652	Phobius	NON_CYTOPLASMIC_DOMAIN	Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.
390	651	SMART	SM00283	MA_2
390	651	InterPro	IPR004089	Methyl-accepting chemotaxis protein (MCP) signalling domain
37	301	SMART	SM01358	HBM_sequencesselection_2
37	301	InterPro	IPR032255	Helical bimodular sensor domain
417	616	CDD	cd11386	MCP_signal
322	371	Pfam	PF00672	HAMP domain
322	371	InterPro	IPR003660	HAMP domain
25	651	PANTHER	PTHR32089	METHYL-ACCEPTING CHEMOTAXIS PROTEIN MCPB
326	370	CDD	cd06225	HAMP
20	43	Phobius	TRANSMEMBRANE	Region of a membrane-bound protein predicted to be embedded in the membrane.
191	211	Coils	Coil	Coil
323	652	Gene3D	G3DSA:1.10.287.950	-
20	42	TMHMM	TMhelix	Region of a membrane-bound protein predicted to be embedded in the membrane.
580	607	Coils	Coil	Coil
79	99	Coils	Coil	Coil
323	375	ProSiteProfiles	PS50885	HAMP domain profile.
323	375	InterPro	IPR003660	HAMP domain
301	323	TMHMM	TMhelix	Region of a membrane-bound protein predicted to be embedded in the membrane.
323	652	FunFam	G3DSA:1.10.287.950:FF:000001	Methyl-accepting chemotaxis sensory transducer
458	478	Coils	Coil	Coil
436	618	Pfam	PF00015	Methyl-accepting chemotaxis protein (MCP) signalling domain
436	618	InterPro	IPR004089	Methyl-accepting chemotaxis protein (MCP) signalling domain
44	300	Phobius	CYTOPLASMIC_DOMAIN	Region of a membrane-bound protein predicted to be outside the membrane, in the cytoplasm.
343	652	SUPERFAMILY	SSF58104	Methyl-accepting chemotaxis protein (MCP) signaling domain
380	616	ProSiteProfiles	PS50111	Bacterial chemotaxis sensory transducers domain profile.
380	616	InterPro	IPR004089	Methyl-accepting chemotaxis protein (MCP) signalling domain
301	326	Phobius	TRANSMEMBRANE	Region of a membrane-bound protein predicted to be embedded in the membrane.
1	19	Phobius	NON_CYTOPLASMIC_DOMAIN	Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.
45	296	ProSiteProfiles	PS51753	HBM domain profile.
45	296	InterPro	IPR032255	Helical bimodular sensor domain
27	126	Gene3D	G3DSA:1.20.1440.210	-
323	375	SMART	SM00304	HAMP_11
376	428	SMART	SM00304	HAMP_11
376	428	InterPro	IPR003660	HAMP domain

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

Loading 3D structure...

Legend High Medium Low

Structural evidence

0 + 1

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry	Method	Resolution	Chain	Coverage	Links	Status
AlphaFold PA1646	AlphaFold	—	—	full sequence	—	Viewing

Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET	Sticks	Spheres	Surfaces	Druggability	Labels	Zoom	Positions
1				0.888
18				0.263
10				0.234

PA1646