Protein profile

PA1657

hypothetical protein

Genome: NC_002516.2

Gene: PA1657 Structure source: AlphaFold UniProt Q9I368
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Amino acids 168
Annotations 1
Features 8
PDB binders 0
Druggability 0.764

Overview

Basic information about this protein and its source genome.

Accession
PA1657
Assembly
Pseudomonas aeruginosa PAO1, complete genome
Gene
PA1657
Status
annotated
Amino acids
168
Structure source
AlphaFold
GO
GO:0033103 The process in which proteins are transferred into the extracellular milieu or directly into host cells by the type VI secretion system. Proteins secreted by this system do not require an N-terminal signal sequence.

Target profile

Computed evidence for target prioritization.

Human off-target
No hit
Gut microbiome off-target
hit
Essential (DEG)
N
Localization
Cytoplasmic

Selected Druggability evidence

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.764
Structure –
Pocket –

Sequence

Primary amino-acid sequence viewer.

MAKEGSVAPKERINVTFKPATGGAQEEIELPLKLLAIGDYTQRADERKVEDRKPIGIDKMTFDEVLAKQELGLTLSVPNRLQEEGGSDELAVGLQINSMKDFNPASIVEQVPELKKLMELRDALVALKGPLGNAPAFRKAIESVLADDESRSRVLGELGLSAAPSQDA

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

1 GO

Gene Ontology (GO)

1
  • GO:0033103 The process in which proteins are transferred into the extracellular milieu or directly into host cells by the type VI secretion system. Proteins secreted by this system do not require an N-terminal signal sequence.

Sequence Features

Domain/signature hits from InterPro and related databases.

8 records
Show feature table
Start End DB Term Name
2 164 PANTHER PTHR35850 CYTOPLASMIC PROTEIN-RELATED
2 164 InterPro IPR008312 Type VI secretion system sheath protein TssB1
6 158 Pfam PF05591 Type VI secretion system, VipA, VC_A0107 or Hcp2
6 158 InterPro IPR008312 Type VI secretion system sheath protein TssB1
3 158 NCBIfam TIGR03358 type VI secretion system contractile sheath small subunit
3 158 InterPro IPR008312 Type VI secretion system sheath protein TssB1
1 168 PIRSF PIRSF028301 UCP028301
1 168 InterPro IPR008312 Type VI secretion system sheath protein TssB1

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

3D visualization script Full viewer

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Structural evidence

0 + 1

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry Method Resolution Chain Coverage Links Status
AlphaFold PA1657
AlphaFold — — full sequence — Viewing
Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET Sticks Spheres Surfaces Druggability Labels Zoom Positions
1 0.764