Protein profile

PA1666

hypothetical protein

Genome: NC_002516.2

Gene: PA1666 Structure source: AlphaFold UniProt Q9I359
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Amino acids 168
Annotations 1
Features 17
PDB binders 0
Druggability 0.77

Overview

Basic information about this protein and its source genome.

Accession
PA1666
Assembly
Pseudomonas aeruginosa PAO1, complete genome
Gene
PA1666
Status
annotated
Amino acids
168
Structure source
AlphaFold
GO
GO:0033103 The process in which proteins are transferred into the extracellular milieu or directly into host cells by the type VI secretion system. Proteins secreted by this system do not require an N-terminal signal sequence.

Target profile

Computed evidence for target prioritization.

Human off-target
No hit
Gut microbiome off-target
hit
Essential (DEG)
N
Localization
Unknown

Selected Druggability evidence

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.77
Structure –
Pocket –

Sequence

Primary amino-acid sequence viewer.

MSRRPIPPARALAMLAVLALLAGCSTLSPYSRLTKLDLALSAGERVNPDLNGRPSPVVVRLFELKHPVAFENADFFSLYERPKETLDPDLVTSEELELRPGERVELKLSVEEGSRYVGVLAAYRDLGEASWRYVVPVTAKELTRVELKLGQKGILNAGELLGKAGDAR

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

1 GO

Gene Ontology (GO)

1
  • GO:0033103 The process in which proteins are transferred into the extracellular milieu or directly into host cells by the type VI secretion system. Proteins secreted by this system do not require an N-terminal signal sequence.

Sequence Features

Domain/signature hits from InterPro and related databases.

17 records
Show feature table
Start End DB Term Name
34 151 Pfam PF12790 Type VI secretion lipoprotein, VasD, EvfM, TssJ, VC_A0113
34 151 InterPro IPR017734 Type VI secretion system, lipoprotein SciN
1 13 SignalP_GRAM_POSITIVE SignalP-TM SignalP-TM
1 10 Phobius SIGNAL_PEPTIDE_N_REGION N-terminal region of a signal peptide.
1 24 ProSiteProfiles PS51257 Prokaryotic membrane lipoprotein lipid attachment site profile.
27 168 Phobius NON_CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.
1 26 Phobius SIGNAL_PEPTIDE Signal peptide region
30 158 Gene3D G3DSA:2.60.40.4150 Type VI secretion system, lipoprotein SciN
30 158 InterPro IPR038706 Type VI secretion protein SciN-like superfamily
1 26 SignalP_EUK SignalP-noTM SignalP-noTM
22 26 Phobius SIGNAL_PEPTIDE_C_REGION C-terminal region of a signal peptide.
12 31 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
1 157 PANTHER PTHR37625 OUTER MEMBRANE LIPOPROTEIN-RELATED
1 157 InterPro IPR017734 Type VI secretion system, lipoprotein SciN
11 21 Phobius SIGNAL_PEPTIDE_H_REGION Hydrophobic region of a signal peptide.
10 154 NCBIfam TIGR03352 type VI secretion system lipoprotein TssJ
10 154 InterPro IPR017734 Type VI secretion system, lipoprotein SciN

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

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Structural evidence

0 + 1

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry Method Resolution Chain Coverage Links Status
AlphaFold PA1666
AlphaFold — — full sequence — Viewing
Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET Sticks Spheres Surfaces Druggability Labels Zoom Positions
2 0.77
1 0.211