Protein profile

PA1668

hypothetical protein

Genome: NC_002516.2

Gene: PA1668 Structure source: AlphaFold UniProt Q9I357
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Amino acids 289
Annotations 1
Features 12
PDB binders 0
Druggability 0.682

Overview

Basic information about this protein and its source genome.

Accession
PA1668
Assembly
Pseudomonas aeruginosa PAO1, complete genome
Gene
PA1668
Status
annotated
Amino acids
289
Structure source
AlphaFold
GO
GO:0033103 The process in which proteins are transferred into the extracellular milieu or directly into host cells by the type VI secretion system. Proteins secreted by this system do not require an N-terminal signal sequence.

Target profile

Computed evidence for target prioritization.

Human off-target
No hit
Gut microbiome off-target
hit
Essential (DEG)
N
Localization
Cytoplasmic

Selected Druggability evidence

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.682
Structure –
Pocket –

Sequence

Primary amino-acid sequence viewer.

MIKEREYHEDEKTVLLDHQGQVPAQGPLTDFAEPPRFEQLEERMIYAARLRPGEAFNVSLNPLVAAASELLSEVVRLKHSTVLENLAALKERLTSAMKLFEFRAVQDGVENSQVMAARYVLCTVVDEAVVTTPWGNESEWSKISLLSSFHNETFGGEKFFQLLDRLSKNPVKHLPMLELMYLCLALGFEGKYRVMARGVLDLDGISDALYRQIRQLRGDVPRELSPHWQGLSDQRRGLVRIVPWWMVALFTLVCLVVMYSGFAWVLGEQRDTVLQPYQSLDAAAGQPGS

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

1 GO

Gene Ontology (GO)

1
  • GO:0033103 The process in which proteins are transferred into the extracellular milieu or directly into host cells by the type VI secretion system. Proteins secreted by this system do not require an N-terminal signal sequence.

Sequence Features

Domain/signature hits from InterPro and related databases.

12 records
Show feature table
Start End DB Term Name
58 275 NCBIfam NF038228 type IVB secretion system protein IcmH/DotU
59 217 Gene3D G3DSA:1.25.40.590 Type IV / VI secretion system, DotU
59 217 InterPro IPR038522 Type IV / VI secretion system, DotU superfamily
244 266 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
62 264 Pfam PF09850 Type VI secretion system protein DotU
62 264 InterPro IPR017732 Type IV / VI secretion system, DotU
1 243 Phobius CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the cytoplasm.
244 266 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
22 280 PANTHER PTHR38033 MEMBRANE PROTEIN-RELATED
267 289 Phobius NON_CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.
61 270 NCBIfam TIGR03349 DotU/TssL family secretion system protein
61 270 InterPro IPR017732 Type IV / VI secretion system, DotU

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

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Structural evidence

0 + 1

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry Method Resolution Chain Coverage Links Status
AlphaFold PA1668
AlphaFold — — full sequence — Viewing
Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET Sticks Spheres Surfaces Druggability Labels Zoom Positions
1 0.682
6 0.411