Target Pathogen

Overview

Basic information about this protein and its source genome.

Accession: PA1670
Assembly: Pseudomonas aeruginosa PAO1, complete genome
Gene: PA1670 stp1
Status: annotated
Amino acids: 242
Structure source: AlphaFold

GO

GO:0004722 Catalysis of the reaction: protein serine phosphate + H2O = protein serine + phosphate, and protein threonine phosphate + H2O = protein threonine + phosphate. GO:0033103 The process in which proteins are transferred into the extracellular milieu or directly into host cells by the type VI secretion system. Proteins secreted by this system do not require an N-terminal signal sequence. GO:0007165 The cellular process in which a signal is conveyed to trigger a change in the activity or state of a cell. Signal transduction begins with reception of a signal (e.g. a ligand binding to a receptor or receptor activation by a stimulus such as light), or for signal transduction in the absence of ligand, signal-withdrawal or the activity of a constitutively active receptor. Signal transduction ends with regulation of a downstream cellular process, e.g. regulation of transcription or regulation of a metabolic process. Signal transduction covers signaling from receptors located on the surface of the cell and signaling via molecules located within the cell. For signaling between cells, signal transduction is restricted to events at and within the receiving cell. GO:0006470 The process of removing one or more phosphoric residues from a protein.

Target profile

Computed evidence for target prioritization.

Human off-target: No hit
Gut microbiome off-target: hit
Essential (DEG): N
Localization: Cytoplasmic

Selected Druggability evidence

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.429

Structure –

Pocket –

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

4 GO

Gene Ontology (GO)

4

GO:0004722 Catalysis of the reaction: protein serine phosphate + H2O = protein serine + phosphate, and protein threonine phosphate + H2O = protein threonine + phosphate.
GO:0033103 The process in which proteins are transferred into the extracellular milieu or directly into host cells by the type VI secretion system. Proteins secreted by this system do not require an N-terminal signal sequence.
GO:0007165 The cellular process in which a signal is conveyed to trigger a change in the activity or state of a cell. Signal transduction begins with reception of a signal (e.g. a ligand binding to a receptor or receptor activation by a stimulus such as light), or for signal transduction in the absence of ligand, signal-withdrawal or the activity of a constitutively active receptor. Signal transduction ends with regulation of a downstream cellular process, e.g. regulation of transcription or regulation of a metabolic process. Signal transduction covers signaling from receptors located on the surface of the cell and signaling via molecules located within the cell. For signaling between cells, signal transduction is restricted to events at and within the receiving cell.
GO:0006470 The process of removing one or more phosphoric residues from a protein.

Sequence Features

Domain/signature hits from InterPro and related databases.

16 records

Show feature table

Start	End	DB	Term	Name
7	241	SUPERFAMILY	SSF81606	PP2C-like
7	241	InterPro	IPR036457	PPM-type phosphatase-like domain superfamily
14	240	PANTHER	PTHR13832	PROTEIN PHOSPHATASE 2C
14	240	InterPro	IPR015655	Protein phosphatase 2C family
1	242	FunFam	G3DSA:3.60.40.10:FF:000113	Serine/threonine phosphoprotein phosphatase Stp1
13	242	SMART	SM00331	PP2C_SIG_2
13	242	InterPro	IPR001932	PPM-type phosphatase-like domain
1	242	Gene3D	G3DSA:3.60.40.10	-
1	242	InterPro	IPR036457	PPM-type phosphatase-like domain superfamily
8	241	CDD	cd00143	PP2Cc
8	241	InterPro	IPR001932	PPM-type phosphatase-like domain
18	202	Pfam	PF13672	Protein phosphatase 2C
8	242	ProSiteProfiles	PS51746	PPM-type phosphatase domain profile.
8	242	InterPro	IPR001932	PPM-type phosphatase-like domain
4	240	SMART	SM00332	PP2C_4
4	240	InterPro	IPR001932	PPM-type phosphatase-like domain

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

Loading 3D structure...

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Structural evidence

0 + 1

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry	Method	Resolution	Chain	Coverage	Links	Status
AlphaFold PA1670	AlphaFold	—	—	full sequence	—	Viewing

Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET	Sticks	Spheres	Surfaces	Druggability	Labels	Zoom	Positions
1				0.429

PA1670