Protein profile

PA1678

50S ribosomal protein L3 glutamine methyltransferase

Genome: NC_002516.2

Gene: PA1678 prmB Structure source: AlphaFold UniProt Q9I347
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Amino acids 304
Annotations 10
Features 22
PDB binders 1
Druggability 0.526

Overview

Basic information about this protein and its source genome.

Accession
PA1678
Assembly
Pseudomonas aeruginosa PAO1, complete genome
Gene
PA1678 prmB
Status
annotated
Amino acids
304
Structure source
AlphaFold
EC
2.1.1.298
GO
GO:0005829 The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. GO:0003676 Binding to a nucleic acid. GO:0036009 Catalysis of the reaction: L-glutaminyl-[protein] + S-adenosyl-L-methionine = N(5)-methyl-L-glutaminyl-[protein] + S-adenosyl-L-homocysteine + H+. GO:0032259 The process in which a methyl group is covalently attached to a molecule. GO:0008276 Catalysis of the transfer of a methyl group (CH3-) to a protein. GO:0009007 Catalysis of the reaction: S-adenosyl-L-methionine + DNA adenine = S-adenosyl-L-homocysteine + DNA 6-methylaminopurine.

Target profile

Computed evidence for target prioritization.

Human off-target
hit
Human identity (%)
26.838
Human E-value
6.33e-17
Gut microbiome off-target
hit
Essential (DEG)
Y
Localization
Cytoplasmic

Selected Druggability evidence

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.526
Structure –
Pocket –

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

1 EC 9 GO

Enzyme Commission (EC)

1

Gene Ontology (GO)

9
  • GO:0005829 The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
  • GO:0003676 Binding to a nucleic acid.
  • GO:0036009 Catalysis of the reaction: L-glutaminyl-[protein] + S-adenosyl-L-methionine = N(5)-methyl-L-glutaminyl-[protein] + S-adenosyl-L-homocysteine + H+.
  • GO:0032259 The process in which a methyl group is covalently attached to a molecule.
  • GO:0008276 Catalysis of the transfer of a methyl group (CH3-) to a protein.
  • GO:0009007 Catalysis of the reaction: S-adenosyl-L-methionine + DNA adenine = S-adenosyl-L-homocysteine + DNA 6-methylaminopurine.
  • GO:0008168 Catalysis of the transfer of a methyl group to an acceptor molecule.
  • GO:0006479 The addition of a methyl group to a protein amino acid. A methyl group is derived from methane by the removal of a hydrogen atom.
  • GO:0032775 OBSOLETE. The covalent transfer of a methyl group to N-6 of adenine in a DNA molecule.

Sequence Features

Domain/signature hits from InterPro and related databases.

22 records
Show feature table
Start End DB Term Name
8 286 NCBIfam TIGR00536 HemK family protein methyltransferase
128 255 CDD cd02440 AdoMet_MTases
1 293 Hamap MF_02125 50S ribosomal protein L3 glutamine methyltransferase [prmB].
1 293 InterPro IPR017127 Ribosomal protein L3-specific, glutamine-N5-methyltransferase
8 286 InterPro IPR004556 Methyltransferase HemK-like
6 287 NCBIfam TIGR03533 50S ribosomal protein L3 N(5)-glutamine methyltransferase
6 287 InterPro IPR017127 Ribosomal protein L3-specific, glutamine-N5-methyltransferase
1 300 PIRSF PIRSF037167 Mtase_YfcB
1 300 InterPro IPR017127 Ribosomal protein L3-specific, glutamine-N5-methyltransferase
7 98 Gene3D G3DSA:1.10.8.10 -
9 286 SUPERFAMILY SSF53335 S-adenosyl-L-methionine-dependent methyltransferases
9 286 InterPro IPR029063 S-adenosyl-L-methionine-dependent methyltransferase superfamily
197 203 ProSitePatterns PS00092 N-6 Adenine-specific DNA methylases signature.
197 203 InterPro IPR002052 DNA methylase, N-6 adenine-specific, conserved site
102 277 Gene3D G3DSA:3.40.50.150 Vaccinia Virus protein VP39
102 277 InterPro IPR029063 S-adenosyl-L-methionine-dependent methyltransferase superfamily
2 301 PANTHER PTHR47806 50S RIBOSOMAL PROTEIN L3 GLUTAMINE METHYLTRANSFERASE
2 301 InterPro IPR017127 Ribosomal protein L3-specific, glutamine-N5-methyltransferase
122 208 Pfam PF05175 Methyltransferase small domain
122 208 InterPro IPR007848 Methyltransferase small domain
7 97 FunFam G3DSA:1.10.8.10:FF:000022 50S ribosomal protein L3 glutamine methyltransferase
98 272 FunFam G3DSA:3.40.50.150:FF:000042 50S ribosomal protein L3 glutamine methyltransferase

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

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Structural evidence

0 + 1

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry Method Resolution Chain Coverage Links Status
AlphaFold PA1678
AlphaFold — — full sequence — Viewing
Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET Sticks Spheres Surfaces Druggability Labels Zoom Positions
2 0.526
1 0.278

Ligand evidence

Ligands grouped by evidence source. PDB ligands keep the source crystal visible, and loaded crystals can be opened directly in the structure viewer.

51 records

Structural evidence inferred from similar proteins. The source crystal indicates where the ligand was observed; the UniProt column identifies the homologous protein carrying that ligand.

Show only:
Ligand Source crystal UniProt (homolog) MW · LogP · TPSA Lipinski PAINS SMILES
MEQ
1NV8
Q9WYV8 160.2 Da LogP -1.08 TPSA 92.4 ✓ Ro5 ✓ Clean CNC(=O)CC[C@@H](C(=O)O)N

PDB and ChEMBL records on this protein are shown in full. ChEMBL records from similar proteins are capped at the top 100 per protein (by pchembl) and ZINC at the top 50 (Tanimoto ≥ 0.5). ADME columns are descriptor-based screening flags, not experimental toxicity results.