Protein profile

PA1690

translocation protein in type III secretion

Genome: NC_002516.2

Gene: PA1690 pscU Structure source: Experimental + AlphaFold UniProt Q9I337
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Amino acids 349
Annotations 3
Features 34
PDB binders 0
Druggability 0.364

Overview

Basic information about this protein and its source genome.

Accession
PA1690
Assembly
Pseudomonas aeruginosa PAO1, complete genome
Gene
PA1690 pscU
Status
annotated
Amino acids
349
Structure source
Experimental + AlphaFold
GO
GO:0005886 The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. GO:0009306 The controlled release of proteins from a cell. GO:0016020 A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it.

Target profile

Computed evidence for target prioritization.

Human off-target
No hit
Gut microbiome off-target
hit
Essential (DEG)
N
Localization
CytoplasmicMembrane

Selected Druggability evidence

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.364
Structure –
Pocket –

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

3 GO

Gene Ontology (GO)

3
  • GO:0005886 The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
  • GO:0009306 The controlled release of proteins from a cell.
  • GO:0016020 A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it.

Sequence Features

Domain/signature hits from InterPro and related databases.

34 records
Show feature table
Start End DB Term Name
206 349 Phobius CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the cytoplasm.
211 348 Gene3D G3DSA:3.40.1690.10 secretion proteins EscU
211 348 InterPro IPR029025 Type III secretion system substrate exporter, C-terminal
1 28 Phobius CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the cytoplasm.
184 206 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
238 343 SUPERFAMILY SSF160544 EscU C-terminal domain-like
238 343 InterPro IPR029025 Type III secretion system substrate exporter, C-terminal
83 112 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
4 343 NCBIfam TIGR01404 type III secretion system export apparatus subunit SctU
4 343 InterPro IPR006307 Type III exporter system, secretion apparatus protein BsaZ-like
29 50 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
167 185 Phobius NON_CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.
211 231 Coils Coil Coil
186 205 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
90 112 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
113 146 Phobius CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the cytoplasm.
2 346 PANTHER PTHR30531 FLAGELLAR BIOSYNTHETIC PROTEIN FLHB
2 346 InterPro IPR006135 Type III secretion system substrate exporter
296 317 PRINTS PR00950 Type III secretion system inner membrane S protein family signature
296 317 InterPro IPR006135 Type III secretion system substrate exporter
266 281 PRINTS PR00950 Type III secretion system inner membrane S protein family signature
266 281 InterPro IPR006135 Type III secretion system substrate exporter
202 220 PRINTS PR00950 Type III secretion system inner membrane S protein family signature
202 220 InterPro IPR006135 Type III secretion system substrate exporter
222 239 PRINTS PR00950 Type III secretion system inner membrane S protein family signature
222 239 InterPro IPR006135 Type III secretion system substrate exporter
6 28 PRINTS PR00950 Type III secretion system inner membrane S protein family signature
6 28 InterPro IPR006135 Type III secretion system substrate exporter
4 340 Pfam PF01312 FlhB HrpN YscU SpaS Family
4 340 InterPro IPR006135 Type III secretion system substrate exporter
51 82 Phobius NON_CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.
147 169 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
147 166 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
28 50 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

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Structural evidence

1 + 1

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry Method Resolution Chain Coverage Links Status
PDB 5CUL
X-ray 2.90 Å A,B
35.2% 220-342
PDBe RCSB PDBj File
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AlphaFold PA1690
AlphaFold — — full sequence — Loaded
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Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET Sticks Spheres Surfaces Druggability Labels Zoom Positions
1 0.364