Protein profile

PA1698

type III secretion outer membrane protein PopN

Genome: NC_002516.2

Gene: PA1698 popN Structure source: AlphaFold UniProt G3XCX6
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Amino acids 288
Annotations 5
Features 7
PDB binders 0
Druggability 0.812

Overview

Basic information about this protein and its source genome.

Accession
PA1698
Assembly
Pseudomonas aeruginosa PAO1, complete genome
Gene
PA1698 popN
Status
annotated
Amino acids
288
Structure source
AlphaFold
GO
GO:0009986 The external part of the cell wall and/or plasma membrane. GO:0019867 The external membrane of Gram-negative bacteria or certain organelles such as mitochondria and chloroplasts; freely permeable to most ions and metabolites. GO:0050709 Any process that stops, prevents, or reduces the frequency, rate or extent of the controlled release of a protein from a cell. GO:0030254 The process in which proteins are transferred into the extracellular milieu or directly into host cells by the bacterial type III secretion system; secretion occurs in a continuous process without the distinct presence of periplasmic intermediates and does not involve proteolytic processing of secreted proteins. GO:0046903 The controlled release of a substance by a cell or a tissue.

Target profile

Computed evidence for target prioritization.

Human off-target
No hit
Gut microbiome off-target
hit
Essential (DEG)
N
Localization
OuterMembrane

Selected Druggability evidence

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.812
Structure –
Pocket –

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

5 GO

Gene Ontology (GO)

5
  • GO:0009986 The external part of the cell wall and/or plasma membrane.
  • GO:0019867 The external membrane of Gram-negative bacteria or certain organelles such as mitochondria and chloroplasts; freely permeable to most ions and metabolites.
  • GO:0050709 Any process that stops, prevents, or reduces the frequency, rate or extent of the controlled release of a protein from a cell.
  • GO:0030254 The process in which proteins are transferred into the extracellular milieu or directly into host cells by the bacterial type III secretion system; secretion occurs in a continuous process without the distinct presence of periplasmic intermediates and does not involve proteolytic processing of secreted proteins.
  • GO:0046903 The controlled release of a substance by a cell or a tissue.

Sequence Features

Domain/signature hits from InterPro and related databases.

7 records
Show feature table
Start End DB Term Name
28 63 Gene3D G3DSA:6.10.250.670 -
68 263 SUPERFAMILY SSF140591 Type III secretion system domain
167 252 Gene3D G3DSA:1.10.150.630 -
54 217 Pfam PF07201 HrpJ-like domain
54 217 InterPro IPR010812 Hypersensitivity response secretion-like, HrpJ
30 276 NCBIfam TIGR02568 type III secretion system gatekeeper subunit SctW
30 276 InterPro IPR013401 Type III secretion regulator, YopN/LcrE/InvE/MxiC

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

3D visualization script Full viewer

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Structural evidence

0 + 1

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry Method Resolution Chain Coverage Links Status
AlphaFold PA1698
AlphaFold — — full sequence — Viewing
Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET Sticks Spheres Surfaces Druggability Labels Zoom Positions
1 0.812
7 0.346